Physosmotic Induction of Chondrogenic Maturation Is TGF-β Dependent and Enhanced by Calcineurin Inhibitor FK506

Autor: Holger Jahr, Anna E. van der Windt, Ufuk Tan Timur, Esther B. Baart, Wei-Shiung Lian, Bernd Rolauffs, Feng-Sheng Wang, Thomas Pufe

Publikováno v: International journal of molecular sciences 23(9), 5110 (2022). doi:10.3390/ijms23095110 special issue: "Special Issue "The Future of Cartilage Repair in Complex Biological Situations 2.0" / Special Issue Editor: Bernd Rolauffs, Guest Editor"
International Journal of Molecular Sciences, 23(9):5110. Multidisciplinary Digital Publishing Institute (MDPI)
International journal of molecular sciences, 23(9):5110. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 5110

International journal of molecular sciences 23(9), 5110 (2022). doi:10.3390/ijms23095110 special issue: "Special Issue "The Future of Cartilage Repair in Complex Biological Situations 2.0" / Special Issue Editor: Bernd Rolauffs, Guest Editor"
Pu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30afd248bd0b245bae4e7c43d8e132af
https://doi.org/10.3390/ijms23095110

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

Autor: Stefanie Hendrikx, Holger Gerhardt, Sina Nassiri, Borja Prat-Luri, Laureline Wetterwald, Claudio A. Franco, Nadine Zangger, Sanja Coso, Tatiana V. Petrova, Mauro Delorenzi, Amélie Sabine

Publikováno v: Cell Reports, Vol 26, Iss 5, Pp 1227-1241.e6 (2019)
Cell reports, vol. 26, no. 5, pp. 1227-1241.e6
Cell Reports

Summary: Calcineurin/NFAT signaling is active in endothelial cells and is proposed to be an essential component of the tumor angiogenic response. Here, we investigated the role of endothelial calcineurin signaling in vivo in physiological and patholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9f368557f59c8f953c87760ea21018
https://doi.org/10.1016/j.celrep.2019.01.016

Corticosteroids Do Not Reverse the Inhibitory Effect of Cyclosporine on Regulatory T-Cell Activity in Contrast to Mycophenolate Mofetil

Autor: Yvon Calmus, Emmanuel Boleslawski, Y. de Launoit, Véronique Pancré, Lynda Aoudjehane, Nadira Delhem, L. Ouaguia, Olivier Moralès, Céline Miroux, Filomena Conti

Publikováno v: Transplantation Proceedings
Transplantation Proceedings, 2012, 44 (9), pp.2834-2839. ⟨10.1016/j.transproceed.2012.09.091⟩
Transplantation Proceedings, Elsevier, 2012, 44 (9), pp.2834-2839. ⟨10.1016/j.transproceed.2012.09.091⟩

International audience; BACKGROUND: Inevitable hepatitis C virus recurrence after liver transplantation, a major barrier to survival of the transplanted liver may be promoted by immunosuppression and by CD4(+)CD25(+) regulatory T cells (Treg). Treg c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3200b1858c131c8084716418afb0113
https://hal.archives-ouvertes.fr/hal-03059987

The calcineurin pathway links hyperpolarization (Kir2.1)-induced Ca2+ signals to human myoblast differentiation and fusion

Autor: Charles R. Bader, Anne Béguet, Laurent Bernheim, Stéphane König

Publikováno v: Development, Vol. 133, No 16 (2006) pp. 3107-3114

In human myoblasts triggered to differentiate, a hyperpolarization,resulting from K+ channel (Kir2.1) activation, allows the generation of an intracellular Ca2+ signal. This signal induces an increase in expression/activity of two key transcription f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845cf40917dfd826823e7e30c0dd86af
https://pubmed.ncbi.nlm.nih.gov/16831831

Phosphorylation of Calcineurin at a Novel Serine-Proline Rich Region Orchestrates Hyphal Growth and Virulence in Aspergillus fumigatus

Autor: Jarrod R. Fortwendel, Praveen R. Juvvadi, Yohannes G. Asfaw, Erik C. Cook, William J. Steinbach, M. Arthur Moseley, Frédéric Lamoth, Christopher Gehrke, Trevor P. Creamer, Michael A. Hast, Erik J. Soderblom

Publikováno v: PLoS Pathogens
PLoS pathogens, vol. 9, no. 8, pp. e1003564
PLoS pathogens
PLoS Pathogens, Vol 9, Iss 8, p e1003564 (2013)

The fungus Aspergillus fumigatus is a leading infectious killer in immunocompromised patients. Calcineurin, a calmodulin (CaM)-dependent protein phosphatase comprised of calcineurin A (CnaA) and calcineurin B (CnaB) subunits, localizes at the hyphal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab6d41ce8afed5d669fe00e47d6921a
https://doi.org/10.1371/journal.ppat.1003564