Spatially clustered type I interferon responses at injury borderzones.

Autor: Ninh VK; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Calcagno DM; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Yu JD; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Zhang B; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Taghdiri N; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Sehgal R; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Mesfin JM; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Chen CJ; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Kalhor K; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Toomu A; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Duran JM; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Adler E; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Hu J; Department of Pathology, University of California San Diego, La Jolla, CA, USA., Zhang K; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Christman KL; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Fu Z; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Bintu B; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA.; Cellular and Molecular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA., King KR; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA. krking@ucsd.edu.; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA. krking@ucsd.edu.

Publikováno v: Nature [Nature] 2024 Sep; Vol. 633 (8028), pp. 174-181. Date of Electronic Publication: 2024 Aug 28.

Single-cell and spatial transcriptomics of the infarcted heart define the dynamic onset of the border zone in response to mechanical destabilization.

Autor: Calcagno DM; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA.; These authors contributed equally: D.M. Calcagno, N. Taghdiri., Taghdiri N; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA.; These authors contributed equally: D.M. Calcagno, N. Taghdiri., Ninh VK; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Mesfin JM; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Toomu A; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Sehgal R; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Lee J; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Liang Y; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Duran JM; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Adler E; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Christman KL; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Zhang K; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., Sheikh F; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA., Fu Z; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA., King KR; Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, La Jolla, CA, USA.; Division of Cardiology and Cardiovascular Institute, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Nov; Vol. 1 (11), pp. 1039-1055. Date of Electronic Publication: 2022 Nov 17.

Neutrophils incite and macrophages avert electrical storm after myocardial infarction.

Autor: Grune J; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lewis AJM; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; These authors contributed equally and are listed in alphabetical order: Andrew J. M. Lewis, Masahiro Yamazoe., Yamazoe M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; These authors contributed equally and are listed in alphabetical order: Andrew J. M. Lewis, Masahiro Yamazoe., Hulsmans M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Rohde D; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Xiao L; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Zhang S; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ott C; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany., Calcagno DM; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Zhou Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Timm K; Department of Pharmacology, University of Oxford, Oxford, UK., Shanmuganathan M; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health (NIHR) Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Pulous FE; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Schloss MJ; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Foy BH; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Capen D; Program in Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Vinegoni C; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Wojtkiewicz GR; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Iwamoto Y; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Grune T; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany., Brown D; Program in Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Higgins J; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Ferreira VM; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Herring N; National Institute for Health (NIHR) Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Channon KM; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health (NIHR) Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Neubauer S; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; National Institute for Health (NIHR) Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Sosnovik DE; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Milan DJ; Leducq Foundation, Boston, MA, USA., Swirski FK; Cardiovascular Research Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., King KR; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, University of California, San Diego La Jolla, CA, USA., Aguirre AD; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ellinor PT; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nahrendorf M; Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Internal Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Jul; Vol. 1 (7), pp. 649-664. Date of Electronic Publication: 2022 Jul 11.

SiglecF(HI) Marks Late-Stage Neutrophils of the Infarcted Heart: A Single-Cell Transcriptomic Analysis of Neutrophil Diversification.

Autor: Calcagno DM; Department of Bioengineering Jacobs School of Engineering University of California San Diego La Jolla CA., Zhang C; Department of Bioengineering Jacobs School of Engineering University of California San Diego La Jolla CA., Toomu A; Department of Bioengineering Jacobs School of Engineering University of California San Diego La Jolla CA., Huang K; Division of Cardiology and Cardiovascular Institute Department of Medicine University of California San Diego La Jolla CA., Ninh VK; Department of Pharmacology University of California San Diego La Jolla CA., Miyamoto S; Department of Pharmacology University of California San Diego La Jolla CA., Aguirre AD; Cardiology Division Center for Systems Biology Wellman Center for Photomedicine Massachusetts General Hospital Boston MA.; Harvard Medical School Boston MA., Fu Z; Division of Cardiology and Cardiovascular Institute Department of Medicine University of California San Diego La Jolla CA., Heller Brown J; Department of Pharmacology University of California San Diego La Jolla CA., King KR; Department of Bioengineering Jacobs School of Engineering University of California San Diego La Jolla CA.; Division of Cardiology and Cardiovascular Institute Department of Medicine University of California San Diego La Jolla CA.

Publikováno v: Journal of the American Heart Association [J Am Heart Assoc] 2021 Feb 16; Vol. 10 (4), pp. e019019. Date of Electronic Publication: 2021 Feb 02.

Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge.

Autor: Hoyer FF; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Naxerova K; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Schloss MJ; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Hulsmans M; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Nair AV; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Dutta P; Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, BST 1720.1, 200 Lothrop Street, Pittsburgh, PA 15213, USA., Calcagno DM; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA., Herisson F; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Anzai A; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Sun Y; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Wojtkiewicz G; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Rohde D; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Frodermann V; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Vandoorne K; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Courties G; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Iwamoto Y; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Garris CS; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Williams DL; Department of Surgery and Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, 178 Maple Avenue, Johnson City, TN 37614, USA., Breton S; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Brown D; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Whalen M; Neuroscience Center and Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, 55 Fruit Street, MA 02114, USA., Libby P; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA., Pittet MJ; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., King KR; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Weissleder R; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA., Swirski FK; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA., Nahrendorf M; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA; Department of Internal Medicine I, University Hospital Wuerzburg, Wuerzburg, Germany. Electronic address: mnahrendorf@mgh.harvard.edu.

Publikováno v: Immunity [Immunity] 2019 Nov 19; Vol. 51 (5), pp. 899-914.e7. Date of Electronic Publication: 2019 Nov 12.