Výsledky vyhledávání - "Calanolide A"

Akademický článek

An Integrated Computational and Experimental Approach to Formulate Tamanu Oil Bigels as Anti-Scarring Agent

Autor: Megha Krishnappa, Sindhu Abraham, Sharon Caroline Furtado, Shwetha Krishnamurthy, Aynul Rifaya, Yahya I. Asiri, Kumarappan Chidambaram, Parasuraman Pavadai

Publikováno v: Pharmaceuticals, Vol 17, Iss 1, p 102 (2024)

Tamanu oil has traditionally been used to treat various skin problems. The oil has wound-healing and skin-regenerating capabilities and encourages the growth of new skin cells, all of which are helpful for fading scars and hyperpigmentation, as well

Externí odkaz: https://doaj.org/article/be140efbca3a49afabb46fbd5c3e3654

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Akademický článek

Bioinspired Pyrano[2,3-f]chromen-8-ones: Ring C-Opened Analogues of Calanolide A: Synthesis and Anti-HIV-1 Evaluation

Autor: Igor A. Khalymbadzha, Ramil F. Fatykhov, Ilya I. Butorin, Ainur D. Sharapov, Anastasia P. Potapova, Nibin Joy Muthipeedika, Grigory V. Zyryanov, Vsevolod V. Melekhin, Maria D. Tokhtueva, Sergey L. Deev, Marina K. Kukhanova, Nataliya N. Mochulskaya, Mikhail V. Tsurkan

Publikováno v: Biomimetics, Vol 9, Iss 1, p 44 (2024)

We have designed and synthesized a series of bioinspired pyrano[2,3-f]coumarin-based Calanolide A analogs with anti-HIV activity. The design of these new calanolide analogs involved incorporating nitrogen heterocycles or aromatic groups in lieu of ri

Externí odkaz: https://doaj.org/article/bb4f6881cd7241e0897dfbe5f9b17b6d

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Akademický článek

Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential

Autor: Lutfun Nahar, Anupam Das Talukdar, Deepa Nath, Sushmita Nath, Aman Mehan, Fyaz M. D. Ismail, Satyajit D. Sarker

Publikováno v: Molecules, Vol 25, Iss 21, p 4983 (2020)

Calanolides are tetracyclic 4-substituted dipyranocoumarins. Calanolide A, isolated from the leaves and twigs of Calophyllum lanigerum var. austrocoriaceum (Whitmore) P. F. Stevens, is the first member of this group of compounds with anti-HIV-1 activ

Externí odkaz: https://doaj.org/article/644e19ec6bba4f0e917c7c421ddad05b

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Akademický článek

Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol

Autor: Xiangmeng Wu, Qinghao Zhang, Jiamei Guo, Yufei Jia, Ziqian Zhang, Manman Zhao, Yakun Yang, Baolian Wang, Jinping Hu, Li Sheng, Yan Li

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

10-Chloromethyl-11-demethyl-12-oxo-calanolide (F18), an analog of calanolide A, is a novel potent nonnucleoside reverse transcriptase inhibitor against HIV-1. Here, we report the metabolic profile and the results of associated biochemical studies of

Externí odkaz: https://doaj.org/article/5ff514a7155841f7b5b419cfcb06a26c

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Natural Products with Inhibitory Activity against Human Immunodeficiency Virus Type 1

Autor: Laura Florez-Sampedro, Lina P Orozco, Katherin Ramírez, Maria S. Serna-Arbeláez, Wildeman Zapata, Elkin Galeano

Publikováno v: Advances in Virology
Advances in Virology, Vol 2021 (2021)

Infections caused by human immunodeficiency virus (HIV) are considered one of the main public health problems worldwide. Antiretroviral therapy (ART) is the current modality of treatment for HIV-1 infection. It comprises the combined use of several d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8d4d11b37879441637a9b195eb4ceb
https://doi.org/10.1155/2021/5552088

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Synthesis of novel coumarin analogues: Investigation of molecular docking interaction of SARS-CoV-2 proteins with natural and synthetic coumarin analogues and their pharmacokinetics studies

Autor: Mohamed A. El-Sheikh, Idhayadhulla Akbar, SathishKumar Chidambaram, Surendrakumar Radhakrishnan, Ahmed H. Alfarhan

Publikováno v: Saudi Journal of Biological Sciences, Vol 28, Iss 1, Pp 1100-1108 (2021)
Saudi Journal of Biological Sciences

The severe acute respiratory syndrome coronavirus, identified as SARS-CoV-2, initially established in Wuhan, China at the end of 2019, affects respiratory infections known as COVID-19. In an extraordinary manner, COVID-19 is affecting human life and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530d833eba08e215cf7ed14ef9eb63c5
https://doi.org/10.1016/j.sjbs.2020.11.038

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Akademický článek

A synthesis of (±)-thia-calanolide A, its resolution and in vitro biological evaluation

Autor: Anil U. Chopade, Manojkumar U. Chopade, Bhanu M. Chanda, Dilip D. Sawaikar, Kiran B. Sonawane, Mukund K. Gurjar

Publikováno v: Arabian Journal of Chemistry, Vol 9, Iss S2, Pp S1597-S1602 (2016)

A synthesis of (±)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel–Crafts tigloylation of 5,7-dihydroxy-4-n-propyl thiocoum

Externí odkaz: https://doaj.org/article/838ec68b32654374b10ed01f7e56019b

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