Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis.

Autor: Caiyi C Li, Ivana Munitic, Paul R Mittelstadt, Ehydel Castro, Jonathan D Ashwell

Publikováno v: PLoS Biology, Vol 13, Iss 10, p e1002269 (2015)

Sepsis, an exaggerated systemic inflammatory response, remains a major medical challenge. Both hyperinflammation and immunosuppression are implicated as causes of morbidity and mortality. Dendritic cell (DC) loss has been observed in septic patients

Externí odkaz: https://doaj.org/article/3b3ee67955c340dfb0d7eec8ea2ebe9d

Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis

Autor: Ivana Munitic, Ehydel Castro, Jonathan D. Ashwell, Caiyi C. Li, Paul R. Mittelstadt

Publikováno v: PLoS Biology
PLoS Biology, Vol 13, Iss 10, p e1002269 (2015)

Sepsis, an exaggerated systemic inflammatory response, remains a major medical challenge. Both hyperinflammation and immunosuppression are implicated as causes of morbidity and mortality. Dendritic cell (DC) loss has been observed in septic patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050edc5875da3926237cedcb81a6079d
http://europepmc.org/articles/PMC4595142

ToxR interferes with CRP-dependent transcriptional activation of ompT in Vibrio cholerae

Autor: Caiyi C. Li, James B. Kaper, D. Scott Merrell, Andrew Camilli

Publikováno v: Molecular Microbiology. 43:1577-1589

In pathogenic Vibrio cholerae, the transmembrane DNA-binding protein ToxR co-ordinates the expression of over 20 genes, including those encoding important virulence factors such as cholera toxin and the toxin-co-regulated pilus. The outer membrane pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44d920683ae5912011b572d2bea9fd4
https://doi.org/10.1046/j.1365-2958.2002.02845.x

Quorum-sensing Escherichia coli regulator A: a regulator of the LysR family involved in the regulation of the locus of enterocyte effacement pathogenicity island in enterohemorrhagic E. coli

Autor: Caiyi C. Li, Vanessa Sperandio, James B. Kaper

Publikováno v: Infection and immunity. 70(6)

The locus of enterocyte effacement (LEE) is a chromosomal pathogenicity island that encodes the proteins involved in the formation of the attaching and effacing lesions by enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69d13b6228d49562fbc03f001691e83
https://pubmed.ncbi.nlm.nih.gov/12011002

Zfp281 and Zfp148 control CD4 ⁺ T cell thymic development and T H 2 functions.

Autor: Chopp LB; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.; Immunology Graduate Group, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA., Zhu X; Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Gao Y; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Nie J; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Singh J; Single Cell Analysis Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Kumar P; Single Cell Analysis Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Young KZ; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA., Patel S; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.; University of Maryland Medical School, Baltimore, MD 21201, USA., Li C; Flow Cytometry Core, Laboratory of Genomic Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Balmaceno-Criss M; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Vacchio MS; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Wang MM; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.; Neurology Service, VA Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA., Livak F; Flow Cytometry Core, Laboratory of Genomic Integrity, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Merchant JL; Department of Gastroenterology and Hepatology, University of Arizona College of Medicine, Tucson, AZ 85724, USA., Wang L; Institute of Immunology, and Bone Marrow Transplantation Center, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Kelly MC; Single Cell Analysis Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Zhu J; Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Bosselut R; Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Publikováno v: Science immunology [Sci Immunol] 2023 Nov 10; Vol. 8 (89), pp. eadi9066. Date of Electronic Publication: 2023 Nov 10.