Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Caitriona O'Connor"'
Autor:
Alan D. Bennett, Barbara Tavano, Sara Brett, Manoj Saini, Adriano Quattrini, David J. Figueroa, Katherine L Crossland, Terri V Cornforth, Cedrik M. Britten, Joanna E. Brewer, Caitriona O'Connor, Jonathan D. Silk, Dylan Steiner, Alistair G Rust, Andrew B. Gerry, Ryan Wong, Katherine Adams, Joseph P. Sanderson, Annette Pachnio, Carlos E Peredo, Preetha Viswanathan, Junping Jing, Rachel J. M. Abbott, Guy E. Wiedermann, Laura L. Quinn, Lea Patasic, Bent K. Jakobsen
Publikováno v:
The Journal of Immunology. 208:169-180
Adoptive T cell therapy with T cells expressing affinity-enhanced TCRs has shown promising results in phase 1/2 clinical trials for solid and hematological tumors. However, depth and durability of responses to adoptive T cell therapy can suffer from
Autor:
Caitriona, O'Connor, Krishna, Yalla, Mara, Salomé, Hothri Ananyambica, Moka, Eduardo Gómez, Castañeda, Patrick A, Eyers, Karen, Keeshan
Publikováno v:
Oncotarget
Trib2 pseudokinase has oncogenic and tumour suppressive functions depending on the cellular context. We investigated the ability of Trib2 to transform different haemopoietic stem and progenitor cells (HSPCs). Our study identified the granulocyte-macr
Autor:
Mary R. Cahill, Loveena Rishi, Caitriona O'Connor, Jennifer Timoney, Marie Sigurd Hasemann, Karen Keeshan, Joana Campos, Mara Salome, Bo T. Porse, Maura Hannon, Anne-Katrine Frank
Publikováno v:
Blood. 123:2389-2400
The loss of regulation of cell proliferation is a key event in leukemic transformation, and the oncogene tribbles (Trib)2 is emerging as a pivotal target of transcription factors in acute leukemias. Deregulation of the transcription factor E2F1, norm
Publikováno v:
Brain, Behavior, and Immunity. 33:7-13
Adult hippocampal neurogenesis is modulated by a number of intrinsic and extrinsic factors including local signalling molecules, exercise, aging and inflammation. Inflammation is also a major contributor to several hippocampal-associated disorders. I
Publikováno v:
Public health nutrition. 12(1)
ObjectiveTo study patterns of phytosterol intakes in the Irish population from enriched sources.DesignAn interview-assisted questionnaire, which recorded information on sociodemographics, product types, intake amounts and patterns of intake. Independ
Publikováno v:
Experimental Hematology. 43:S77
TRIB2 is a member of the mammalian Tribbles family of serine/threonine pseudokinases (TRIB1, 2, 3). Pathologically, TRIB2 induces potent murine acute myeloid leukemia and is associated with acute lymphoblastic leukemia. However, the normal hematopoie
Publikováno v:
Experimental Hematology. 43:S88
TRIB2, a member of the tribbles family of pseudokinases, is an oncogene implicated in a variety of cancers including T-ALL, liver cancer, cervical cancer and lung cancer. Using a murine bone marrow transplant model, we have shown that TRIB2 overexpre
Autor:
Mary R. Cahill, Caitriona O'Connor, Joana Campos, Ewa Ohlsson, Bo T. Porse, Mara Salome, Patrick A. Kiely, Ciarán G. Forde, Karen Keeshan, Fiona Lohan
Publikováno v:
Experimental Hematology. 42:S42
C/EBPalpha (42 kDa) is commonly dysregulated in acute myeloid leukaemia (AML) by mutation or via the action of AML oncogenes, which can increase the 30 kDa protein oncogenic form of C/EBPalpha (p30). The Trib2 oncogene is associated with dysregulated
Autor:
Brian Murphy, Alison M. Michie, Richard M. Gronostajski, Maura Hannon, Joana Campos, Karen Keeshan, Caitriona O'Connor
Publikováno v:
Experimental Hematology. 42:S54
The commitment of stem and progenitor cells toward specific hematopoietic lineages is tightly controlled by a number of transcription factors that regulate a differentiation program via the expression of lineage restricting genes. Here we report an i
Autor:
Mara Salome, Fiona Lohan, Ruud Delwel, Fiona P. Bailey, Karen Keeshan, Patrick A. Kiely, Patrick A. Eyers, Mary R. Cahill, Caitriona O'Connor, Ciarán G. Forde
Publikováno v:
Blood. 122:3792-3792
The pseudokinase TRIB2 is a potent acute myeloid leukaemia (AML) oncogene, capable of inducing transplantable AML with a relatively short latency in murine models. Functionally, the oncogencity of TRIB2 has been linked to its degradation of CCAAT/enh