Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Caitrin Crudden"'
Autor:
Maarten P. Bebelman, Irfan M. Setiawan, Nick D. Bergkamp, Jeffrey R. van Senten, Caitrin Crudden, Jan Paul M. Bebelman, Frederik J. Verweij, Guillaume van Niel, Marco Siderius, D. Michiel Pegtel, Martine J. Smit
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107412- (2023)
Summary: The human cytomegalovirus (HCMV)-encoded chemokine receptor US28 contributes to various aspects of the viral life cycle and promotes immune evasion by scavenging chemokines from the microenvironment of HCMV-infected cells. In contrast to the
Externí odkaz:
https://doaj.org/article/3584ed7d87864108bd8d9bb36453dd90
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 149-157 (2021)
The discovery that cancer cells discharge vast quantities of extracellular vesicles (EVs), underscored the explosion of the EV field. A large body of evidence now supports their onco-functionality in an array of contexts; stromal crosstalk, immune ev
Externí odkaz:
https://doaj.org/article/db00166357514548ab2a9dd0df744731
Autor:
Caitrin Crudden, Dawei Song, Sonia Cismas, Eric Trocmé, Sylvya Pasca, George A. Calin, Ada Girnita, Leonard Girnita
Publikováno v:
Cells, Vol 8, Iss 10, p 1223 (2019)
Ligand-activated plasma membrane receptors follow pathways of endocytosis through the endosomal sorting apparatus. Receptors cluster in clathrin-coated pits that bud inwards and enter the cell as clathrin-coated vesicles. These vesicles travel throug
Externí odkaz:
https://doaj.org/article/3ca09e14e6e5416180b1992705cc5382
Autor:
Maarten P. Bebelman, Caitrin Crudden, Bart Snieder, Evangelia Thanou, Catharina J.M. Langedijk, Margarida Viola, Steven Eleonora, Urszula Baginska, Olaf Cotugno, Jan Paul M. Bebelman, Monique A.J. van Eijndhoven, Leontien Bosch, Ka Wan Li, Martine J. Smit, Guillaume van Niel, August B. Smit, Frederik J. Verweij, D. Michiel Pegtel
Dysregulated extracellular vesicle (EV) release has been implicated in various pathologies, including cancer, neurodegenerative disease and osteoarthritis. Despite clear therapeutic potential, drug screening for EV release modulators has yielded limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f564ca74c198c33f77f318f016ad3a26
https://doi.org/10.1101/2023.02.23.529257
https://doi.org/10.1101/2023.02.23.529257
Autor:
Caitrin Crudden, Julianna Serly, Ada Girnita, Daniela Nedelcu, George A. Calin, Dawei Song, Sonia Cismas, Takashi Shibano, Enrique Fuentes-Mattei, Mihnea P. Dragomir, Andrei Adrian Tica, Leonard Girnita
Publikováno v:
Cancer Research, 81(2), 501-515. American Association for Cancer Research Inc.
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G Protein–Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G protein-coupled receptor kinase 2 promotes unbiased downregulation of IGF-1 receptor and restrains malignant cell growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G Protein–Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662
Crudden, C, Shibano, T, Song, D, Dragomir, M P, Cismas, S, Serly, J, Nedelcu, D, Fuentes-Mattei, E, Tica, A, Calin, G A, Girnita, A & Girnita, L 2021, ' Inhibition of G protein-coupled receptor kinase 2 promotes unbiased downregulation of IGF-1 receptor and restrains malignant cell growth ', Cancer Research, vol. 81, no. 2, pp. 501-515 . https://doi.org/10.1158/0008-5472.CAN-20-1662
The ability of a receptor to preferentially activate only a subset of available downstream signal cascades is termed biased signaling. Although comprehensively recognized for the G protein–coupled receptors (GPCR), this process is scarcely explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21c7e9c4286ac0504758d5103d6ab87
https://doi.org/10.1158/0008-5472.can-20-1662
https://doi.org/10.1158/0008-5472.can-20-1662
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 149-157 (2021)
Neoplasia
Bebelman, M P, Janssen, E, Pegtel, D M & Crudden, C 2021, ' The forces driving cancer extracellular vesicle secretion ', Neoplasia (United States), vol. 23, no. 1, pp. 149-157 . https://doi.org/10.1016/j.neo.2020.11.011
Neoplasia (New York, N.Y.)
Neoplasia, 23(1), 149-157. Elsevier Inc.
Crudden, C J 2021, ' The forces driving cancer extracellular vesicle secretion ', Neoplasia, vol. 23, no. 1, pp. 149-157 . https://doi.org/10.1016/j.neo.2020.11.011
Neoplasia
Bebelman, M P, Janssen, E, Pegtel, D M & Crudden, C 2021, ' The forces driving cancer extracellular vesicle secretion ', Neoplasia (United States), vol. 23, no. 1, pp. 149-157 . https://doi.org/10.1016/j.neo.2020.11.011
Neoplasia (New York, N.Y.)
Neoplasia, 23(1), 149-157. Elsevier Inc.
Crudden, C J 2021, ' The forces driving cancer extracellular vesicle secretion ', Neoplasia, vol. 23, no. 1, pp. 149-157 . https://doi.org/10.1016/j.neo.2020.11.011
The discovery that cancer cells discharge vast quantities of extracellular vesicles (EVs), underscored the explosion of the EV field. A large body of evidence now supports their onco-functionality in an array of contexts; stromal crosstalk, immune ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95acf7bfb3449551be6bc8536353ae7
http://www.sciencedirect.com/science/article/pii/S1476558620301792
http://www.sciencedirect.com/science/article/pii/S1476558620301792
Autor:
Dawei Song, Sonia Cismas, Caitrin Crudden, Eric Trocme, Claire Worrall, Naida Suleymanova, Tingting Lin, Huiyuan Zheng, Stefan Seregard, Ada Girnita, Leonard Girnita
Publikováno v:
Oncogene. 42:858-858
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ba23aedb33c0ec8baf233dd95c6413
https://doi.org/10.1038/s41388-023-02607-8
https://doi.org/10.1038/s41388-023-02607-8
Autor:
Tingting Lin, Leonard Girnita, Dawei Song, Eric Trocme, H. Zheng, Stefan Seregard, Naida Suleymanova, Caitrin Crudden, Ada Girnita, C. Worrall, Sonia Cismas
Publikováno v:
Oncogene. Nature Publishing Group
Oncogene, 41(4), 600-611. Nature Publishing Group
Song, D, Cismas, S, Crudden, C, Trocme, E, Worrall, C, Suleymanova, N, Lin, T, Zheng, H, Seregard, S, Girnita, A & Girnita, L 2022, ' IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma ', Oncogene, vol. 41, no. 4, pp. 600-611 . https://doi.org/10.1038/s41388-021-02111-x
Song, D, Cismas, S, Crudden, C, Trocme, E, Worrall, C, Suleymanova, N, Lin, T, Zheng, H, Seregard, S, Girnita, A & Girnita, L 2021, ' IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma ', Oncogene . https://doi.org/10.1038/s41388-021-02111-x
Oncogene, 41(4), 600-611. Nature Publishing Group
Song, D, Cismas, S, Crudden, C, Trocme, E, Worrall, C, Suleymanova, N, Lin, T, Zheng, H, Seregard, S, Girnita, A & Girnita, L 2022, ' IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma ', Oncogene, vol. 41, no. 4, pp. 600-611 . https://doi.org/10.1038/s41388-021-02111-x
Song, D, Cismas, S, Crudden, C, Trocme, E, Worrall, C, Suleymanova, N, Lin, T, Zheng, H, Seregard, S, Girnita, A & Girnita, L 2021, ' IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma ', Oncogene . https://doi.org/10.1038/s41388-021-02111-x
As the p53 tumor suppressor is rarely mutated in conjunctival melanoma (CM), we investigated its activation as a potential therapeutic strategy. Preventing p53/Mdm2 interaction by Nutlin-3, the prototypical Mdm2 antagonist, or via direct siRNA Mdm2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3803babfe5dd12b648655ab9c29a7ef9
https://research.vumc.nl/en/publications/402de235-aa61-47e7-b2ef-02e0d662b9ee
https://research.vumc.nl/en/publications/402de235-aa61-47e7-b2ef-02e0d662b9ee
Autor:
Leonard Girnita, Caitrin Crudden
Publikováno v:
Crudden, C & Girnita, L 2020, ' The tale of a tail : The secret behind IGF-1R's oncogenic power ', Science Signaling, vol. 13, no. 633 . https://doi.org/10.1126/scisignal.abb7887
Science Signaling. American Association for the Advancement of Science
Science Signaling, 13(632):eabb7887. American Association for the Advancement of Science
Crudden, C & Girnita, L 2020, ' The tale of a tail : The secret behind IGF-1R’s oncogenic power ', Science Signaling, vol. 13, no. 632, eabb7887 . https://doi.org/10.1126/scisignal.abc8254
Science Signaling. American Association for the Advancement of Science
Science Signaling, 13(632):eabb7887. American Association for the Advancement of Science
Crudden, C & Girnita, L 2020, ' The tale of a tail : The secret behind IGF-1R’s oncogenic power ', Science Signaling, vol. 13, no. 632, eabb7887 . https://doi.org/10.1126/scisignal.abc8254
The C-terminal tail of insulin-like growth factor 1 receptor (IGF-1R) has long been appreciated to drive much of this receptor’s oncogenic power. In this issue of Science Signaling, Rieger et al. have shown that Tyr1250 and Tyr1251 of IGF-1R are au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6787c0d8466c0b9ea28c5aa37e529569
https://research.vumc.nl/en/publications/358d2980-d690-4cc7-9d55-cbcff976c73f
https://research.vumc.nl/en/publications/358d2980-d690-4cc7-9d55-cbcff976c73f
Autor:
Caitrin Crudden
Publikováno v:
Science Signaling. 13
Conformational changes in the C-terminal region of PLC-β2 caused by G proteins release autoinhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e93f288de9b3ee519f6c0e07aad9f527
https://doi.org/10.1126/scisignal.abc8254
https://doi.org/10.1126/scisignal.abc8254