Výsledky vyhledávání - "Caitlyn H. McNaughton"

Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus

Autor: Sophie Parmentier-Batteur, Caitlyn H. McNaughton, Marlene A. Jacobson, Nathaniel O. Surles, Pete H. Hutson, Jason M. Uslaner, June S.H. Lam, Rosemarie Beth Flick

Publikováno v: Neuropharmacology. 57:531-538

In the search for strategies to treat schizophrenia, attention has focused on enhancing NMDA receptor function. In vitro experiments show that metabotropic glutamate 5 receptor (mGluR5) activation enhances NMDA receptor activity, and in vivo experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8a5d38e084bf04c7fa986cf1188b20
https://doi.org/10.1016/j.neuropharm.2009.07.022

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MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia?

Autor: Caitlyn H. McNaughton, Sarah L. Huszar, Peter H. Hutson, Joshua D. Vardigan, Jason M. Uslaner

Publikováno v: Pharmacology, biochemistry, and behavior. 95(2)

Currently prescribed antipsychotics attenuate the positive symptoms of schizophrenia but fail or only mildly improve negative symptoms. The present study aimed to establish an animal model of negative symptoms by examining the effects of the NMDA rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f0cc83ceabd3f93c5b480f88ae248a
https://pubmed.ncbi.nlm.nih.gov/20122952

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The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine

Autor: Nathan O. Surles, Nancy A. Sachs, Jason M. Uslaner, Tim Sparey, Monika Kandebo, Mary Beth Young, Richard M. Hinchliffe, Caitlyn H. McNaughton, Brian A. Jones, Shankar Venkatraman, Marlene A. Jacobson, Peter H. Hutson, Lihang Yao, Sean M. Smith, Sarah L. Huszar, Danette Pascarella, Nicholas J. Brandon, Chadwick M. Mullins

Publikováno v: The Journal of pharmacology and experimental therapeutics. 328(3)

Multiple studies indicate that N-methyl-D-aspartate (NMDA) receptor hypofunction underlies some of the deficits associated with schizophrenia. One approach for improving NMDA receptor function is to enhance occupancy of the glycine modulatory site on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a89a1799024e687916b557780979727
https://pubmed.ncbi.nlm.nih.gov/19088300

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