Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Caitlyn A. Thomas"'
Autor:
Bogdan M. Benin, Trae Hillyer, Aylin S. Crugnale, Andrew Fulk, Caitlyn A. Thomas, Michael W. Crowder, Matthew A. Smith, Woo Shik Shin
Publikováno v:
Microorganisms, Vol 11, Iss 11, p 2653 (2023)
Among the various mechanisms that bacteria use to develop antibiotic resistance, the multiple expression of β-lactamases is particularly problematic, threatening public health and increasing patient mortality rates. Even if a combination therapy—i
Externí odkaz:
https://doaj.org/article/7d888425b408427f9c214a1c522020eb
Autor:
Zishuo Cheng, Ben A. Shurina, Christopher R. Bethel, Pei W. Thomas, Steven H. Marshall, Caitlyn A. Thomas, Kundi Yang, Robert L. Kimble, Jonathan S. Montgomery, Matthew G. Orischak, Callie M. Miller, Jordan L. Tennenbaum, Jay C. Nix, David L. Tierney, Walter Fast, Robert A. Bonomo, Richard C. Page, Michael W. Crowder
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT To understand the evolution of Verona integron-encoded metallo-β-lactamase (VIM) genes (blaVIM) and their clinical impact, microbiological, biochemical, and structural studies were conducted. Forty-five clinically derived VIM variants engin
Externí odkaz:
https://doaj.org/article/456a2252f5b9467492680466c100f2cc
Autor:
Zishuo Cheng, Caitlyn A. Thomas, Adam R. Joyner, Robert L. Kimble, Aidan M. Sturgill, Nhu-Y Tran, Maya R. Vulcan, Spencer A. Klinsky, Diego J. Orea, Cody R. Platt, Fanpu Cao, Bo Li, Qilin Yang, Cole J. Yurkiewicz, Walter Fast, Michael W. Crowder
Publikováno v:
Biomolecules, Vol 10, Iss 3, p 459 (2020)
In an effort to facilitate the discovery of new, improved inhibitors of the metallo-β-lactamases (MBLs), a new, interactive website called MBLinhibitors.com was developed. Despite considerable efforts from the science community, there are no clinica
Externí odkaz:
https://doaj.org/article/12023965576442398009cfa250409433
Discovery of an Effective Small-Molecule Allosteric Inhibitor of New Delhi Metallo-β-lactamase (NDM)
Autor:
Pei W. Thomas, Eun Jeong Cho, Christopher R. Bethel, Thomas Smisek, Yeong-Chan Ahn, John M. Schroeder, Caitlyn A. Thomas, Kevin N. Dalby, Josh T. Beckham, Michael W. Crowder, Robert A. Bonomo, Walter Fast
Publikováno v:
ACS Infectious Diseases. 8:811-824
To identify novel inhibitors of the carbapenemase New Delhi metallo-β-lactamase (NDM) as possible therapeutic compounds, we conducted a high-throughput screen of a 43,358-compound library. One of these compounds, a 2-quinazolinone linked through a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb67a67c07ab43dc1326f73bfe7fdaf
https://doi.org/10.1021/acsinfecdis.1c00577
https://doi.org/10.1021/acsinfecdis.1c00577
Autor:
Colin Blake, Caitlyn A. Thomas, Árpád Somogyi, David Dafoe, Shenyuan Xu, Michael W. Crowder, Callie Miller, Huan Zhang, Kundi Yang, Clay Smith, Zishuo Cheng, Neil D. Danielson, Devin Spivey
Publikováno v:
Food Analytical Methods. 13:2301-2311
In an effort to characterize differently aged bourbons and to determine whether bourbons could be “fingerprinted” by their chemical compositions, we used Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) and liquid chromatog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de6fb4c2c2f4926df0d0036a82239747
https://doi.org/10.1007/s12161-020-01850-z
https://doi.org/10.1007/s12161-020-01850-z
Autor:
Ben A. Shurina, Caitlyn A. Thomas, Alexander Bergstrom, Stacey Lowery Bretz, Callie Miller, Kundi Yang, Lin-Cheng Ju, Zishuo Cheng, Sarah Fullington, Michael W. Crowder, David L. Tierney, Richard C. Page
Publikováno v:
J Biol Inorg Chem
Due to the rapid proliferation of antibiotic-resistant pathogenic bacteria, known as Carbapenem-Resistant Enterobacteriaceae (CRE), the efficacy of β-lactam antibiotics is threatened. β-Lactam antibiotics constitute over 50% of the available antibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01996bbc4e30bd78171d142ed504b143
https://doi.org/10.1007/s00775-020-01794-z
https://doi.org/10.1007/s00775-020-01794-z
Autor:
Caitlyn A. Thomas, Kundi Yang, Walter Fast, Zishuo Cheng, Seth M. Cohen, Michael W. Crowder, Allie Y. Chen, Pei W. Thomas
Publikováno v:
ChemMedChem
The fungal natural product Aspergillomarasmine A (AMA) has been identified as a non-competitive inhibitor of New Delhi Metallo-β-lactamase-1 (NDM-1) that inhibits via active site Zn(II) removal. The non-selective metal-chelating properties and the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd5f29c9ff1aa0d1020e736f12ce455
https://doi.org/10.1002/cmdc.202000123
https://doi.org/10.1002/cmdc.202000123
Autor:
Alice Legru, Federica Verdirosa, Yen Vo-Hoang, Giusy Tassone, Filippo Vascon, Caitlyn A. Thomas, Filomena Sannio, Giuseppina Corsica, Manuela Benvenuti, Georges Feller, Rémi Coulon, Francesca Marcoccia, Savannah Rowane Devente, Ezeddine Bouajila, Catherine Piveteau, Florence Leroux, Rebecca Deprez-Poulain, Benoît Deprez, Patricia Licznar-Fajardo, Michael W. Crowder, Laura Cendron, Cecilia Pozzi, Stefano Mangani, Jean-Denis Docquier, Jean-François Hernandez, Laurent Gavara
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16392-16419. ⟨10.1021/acs.jmedchem.2c01257⟩
Journal of Medicinal Chemistry, 2022, 65 (24), pp.16392-16419. ⟨10.1021/acs.jmedchem.2c01257⟩
International audience; Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to preserve these important antibacterial drugs. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a12a2619992adab250d34ee8e40f7d5
https://hdl.handle.net/11577/3465209
https://hdl.handle.net/11577/3465209
Autor:
Dominique Tan, Alesha C. Stewart, Caitlyn A. Thomas, Dann D Rivera, Pei W. Thomas, Radhika Mehta, Zishuo Cheng, Abigail Hinojosa, David J. Reilley, Emily L. Que, Anastassia N. Alexandrova, Michael W. Crowder, Walter Fast
Publikováno v:
Journal of the American Chemical Society, vol 143, iss 22
J Am Chem Soc
J Am Chem Soc
New Delhi metallo-β-lactamase (NDM) grants resistance to a broad spectrum of β-lactam antibiotics, including last-resort carbapenems, and is emerging as a global antibiotic resistance threat. Limited zinc availability adversely impacts the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dddee04f76dcee299e12974660e593a
https://escholarship.org/uc/item/7q31084r
https://escholarship.org/uc/item/7q31084r
Autor:
Allie Y. Chen, Zishuo Cheng, Huan Zhang, Diego J. Orea, Abbie Steinbrunner, Seth M. Cohen, Kundi Yang, Caitlyn A. Thomas, Michael W. Crowder, Chathura Paththamperuma, Cecily Pryor, David L. Tierney, Claire Kemp, Maya R. Vulcan, Richard C. Page
Publikováno v:
Bioorg Med Chem
In an effort to probe the biophysical mechanisms of inhibition for ten previously-reported inhibitors of metallo-β-lactamases (MBL) with MBL IMP-1, equilibrium dialysis, metal analyses coupled with atomic absorption spectroscopy (AAS), native state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892830b3601aceec11455acc2c50e003
https://escholarship.org/uc/item/2hm9b5w6
https://escholarship.org/uc/item/2hm9b5w6