Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Caitlin W. Brown"'
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100303- (2021)
Summary: Extracellular vesicles (EVs) play key roles in transporting key molecular constituents as cargo for extracellular trafficking. While several approaches have been developed to extract EVs from mammalian cells, the specific method of EV isolat
Externí odkaz:
https://doaj.org/article/bfa2f2c8a55445c5bc4d06138b1d3be0
Autor:
Caitlin W. Brown, Arthur M. Mercurio
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 3 (2020)
Understanding how cells resist ferroptosis is necessary for exploiting this iron-dependent mode of cell death for the treatment of cancer and other diseases. We discovered that cells resist ferroptosis by enabling a PROMININ2-dependent iron export pa
Externí odkaz:
https://doaj.org/article/0d7c52d073664b1c9a3c502a53178346
Supplementary Figure 1. Reduction in Notch1 levels did not alter levels of col4α2 expression. Supplementary Table 1. List of Antibodies. Supplementary Table 2. List of Primers. Supplementary Table 3. Increased Notch3 expression correlates with incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0c984078a7aa091c12f04de3112ceb
https://doi.org/10.1158/1541-7786.22511376
https://doi.org/10.1158/1541-7786.22511376
Supplementary Figure/Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6286ed41734087843bd700fe5997953c
https://doi.org/10.1158/1541-7786.22511373
https://doi.org/10.1158/1541-7786.22511373
Ovarian cancer is a lethal disease with the majority of diagnosed women having distant metastases. Interestingly, although Notch3 overexpression has been correlated with poor survival in epithelial ovarian cancer (EOC), little is known about its mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c41807403bf0f3b0c4d548d590d50c
https://doi.org/10.1158/1541-7786.c.6539928.v1
https://doi.org/10.1158/1541-7786.c.6539928.v1
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 8, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 8, Pp n/a-n/a (2021)
Understanding how cancer cells resist ferroptosis is a significant problem that impacts ongoing efforts to stimulate ferroptosis as a therapeutic strategy. We reported that prominin2 is induced by ferroptotic stimuli and functions to resist ferroptot
Publikováno v:
Journal of Biological Chemistry. 293:12741-12748
Ferroptosis is an iron-dependent form of programmed cell death characterized by the accumulation of lipid-targeting reactive oxygen species that kill cells by damaging their plasma membrane. The lipid repair enzyme GSH peroxidase 4 (GPX4) protects ag
Publikováno v:
The Journal of Cell Biology
Lipid peroxidation in the plasma membrane can cause ferroptosis, a form of regulated necrosis. Brown et al. show that matrix detachment can induce ferroptosis, and the α6β4 integrin impedes that process by suppressing expression of the proferroptot
Autor:
Wen Xue, Amanda Chan, Hira Lal Goel, Ankur Sheel, Christina E. Baer, John J. Amante, Caitlin W. Brown, Mengdie Wang, Ameer L. Elaimy, Arthur M. Mercurio, Melanie R Walker
Publikováno v:
J Cell Sci
The ability to monitor changes in the expression and localization of integrins is essential for understanding their contribution to development, tissue homeostasis and disease. Here, we pioneered the use of Crispr/Cas9 genome editing to tag an allele
Autor:
Scott J. Dixon, Caitlin W. Brown, Christina E. Baer, John J. Amante, Ameer L. Elaimy, Arthur M. Mercurio, Peter Chhoy, Haibo Liu, Lihua Julie Zhu
Publikováno v:
SSRN Electronic Journal.
Ferroptosis, regulated cell death characterized by the iron-dependent accumulation of lethal lipid reactive oxygen species, contributes to tissue homeostasis and numerous pathologies, and it may be exploited for therapy. Cells differ in their sensiti