Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Caitlin Shepard"'
Autor:
Angel Bulnes-Ramos, Kerstin Schott, Jesse Rabinowitz, Charlotte Luchsinger, Cinzia Bertelli, Eri Miyagi, Corey H. Yu, Mirjana Persaud, Caitlin Shepard, Renate König, Baek Kim, Dmitri N. Ivanov, Klaus Strebel, Felipe Diaz-Griffero
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT In humans, sterile alpha motif (SAM) domain- and histidine–aspartic acid (HD) domain-containing protein 1 (SAMHD1) is a dNTPase enzyme that prevents HIV-1 infection in non-cycling cells, such as differentiated THP-1 cells and human primary
Externí odkaz:
https://doaj.org/article/c9f56ba73d444171b8aaf82bbd3b5756
Autor:
Tianai Sun, Chien-Kuang Cornelia Ding, Yuning Zhang, Yang Zhang, Chao-Chieh Lin, Jianli Wu, Yasaman Setayeshpour, Si’Ana Coggins, Caitlin Shepard, Everardo Macias, Baek Kim, Pei Zhou, Raluca Gordân, Jen-Tsan Chi
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-24 (2022)
Abstract All organisms are constantly exposed to various stresses, necessitating adaptive strategies for survival. In bacteria, the main stress-coping mechanism is the stringent response triggered by the accumulation of “alarmone” (p)ppGpp to arr
Externí odkaz:
https://doaj.org/article/7a49a4d8b7594d4a8a1846204b4d39c6
Autor:
Caitlin Shepard, Joella Xu, Jessica Holler, Dong-Hyun Kim, Louis M. Mansky, Raymond F. Schinazi, Baek Kim
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Terminally differentiated/nondividing macrophages, a key target cell type of HIV-1, harbor extremely low dNTP concentrations established by a host dNTP triphosphohydrolase, SAM domain and HD domain containing protein 1 (SAMHD1). W
Externí odkaz:
https://doaj.org/article/84f81dd739a245cab04437cb7403df15
Autor:
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active i
Externí odkaz:
https://doaj.org/article/3b8f796c4d5d4e31b78e854d8aab59b2
Autor:
Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head, Vishal R. Dhere, Geraldine N. Nabeta, Erin C. Connolly, Erica Werner, Matthew Z. Madden, Michele B. Daly, Elizabeth V. Minten, Donna R. Whelan, Ashley J. Schlafstein, Hui Zhang, Roopesh Anand, Christine Doronio, Allison E. Withers, Caitlin Shepard, Ranjini K. Sundaram, Xingming Deng, William S. Dynan, Ya Wang, Ranjit S. Bindra, Petr Cejka, Eli Rothenberg, Paul W. Doetsch, Baek Kim, David S. Yu
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1921-1935 (2017)
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associate
Externí odkaz:
https://doaj.org/article/0fff215953bf4b47a57af665f31bccaf
Autor:
Adrian Oo, Keivan Zandi, Caitlin Shepard, Leda C. Bassit, Katie Musall, Shu Ling Goh, Young-Jae Cho, Dong-Hyun Kim, Raymond F. Schinazi, Baek Kim
Publikováno v:
The Journal of Biological Chemistry
The lack of antiviral innate immune responses during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is characterized by limited production of interferons (IFNs). One protein associated with Aicardi-Goutières syndrome, SAMHD1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8770fed85c0f447012fc10f86297d1
https://pubmed.ncbi.nlm.nih.gov/35085552
https://pubmed.ncbi.nlm.nih.gov/35085552
Autor:
Tianai Sun, Chien-Kuang Cornelia Ding, Yuning Zhang, Yang Zhang, Chao-Chieh Lin, Jianli Wu, Yasaman Setayeshpour, Si’Ana Coggins, Caitlin Shepard, Everardo Macias, Baek Kim, Pei Zhou, Raluca Gordân, Jen-Tsan Chi
Publikováno v:
Cell deathdisease. 13(3)
All organisms are constantly exposed to various stresses, necessitating adaptive strategies for survival. In bacteria, the main stress-coping mechanism is the stringent response triggered by the accumulation of “alarmone” (p)ppGpp to arrest proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c335be06c9dc5dbb5396609e50f6767
https://pubmed.ncbi.nlm.nih.gov/35273140
https://pubmed.ncbi.nlm.nih.gov/35273140
Autor:
Yong Xiong, Fidel Arizaga, Adrian Oo, Nicole E. Bowen, Caitlin Shepard, Baek Kim, David S. Yu, Joshua Temple, Corey H. Yu, Dmitri N. Ivanov, Felipe Diaz-Griffero, Dong-Hyun Kim, Mirjana Persaud, Priya Kapoor-Vazirani, Raymond F. Schinazi
Publikováno v:
The Journal of Biological Chemistry
Elevated intracellular levels of dNTPs have been shown to be a biochemical marker of cancer cells. Recently, a series of mutations in the multifunctional dNTP triphosphohydrolase (dNTPase), sterile alpha motif and histidine–aspartate domain–conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3d00b0911c2e38bfb2f2ebb6ba3fbe
https://pubmed.ncbi.nlm.nih.gov/34492268
https://pubmed.ncbi.nlm.nih.gov/34492268
Autor:
Joshua Temple, Fidel Arizaga, Baek Kim, Mirjana Persaud, Dong-Hyun Kim, Caitlin Shepard, Yong Xiong, Adrian Oo, Felipe Diaz-Griffero, Nicole E. Bowen, Corey H. Yu, Priya Kapoor-Vazirani, Raymond F. Schinazi, Dmitri N. Ivanov, David S. Yu
Publikováno v:
SSRN Electronic Journal.
Elevated intracellular dNTP level is a biochemical marker of cancer cells. Recently, a series of mutations in a highly multi-functional dNTPase, SAMHD1, have been reported in various cancers. Here we investigated the role of SAMHD1 in cancer by chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f016787597a62c9754d989463fb221a
https://doi.org/10.2139/ssrn.3817806
https://doi.org/10.2139/ssrn.3817806
Autor:
BradleyS. Barrett, David H. Nguyen, Joella Xu, Kejun Guo, Shravida Shetty, Sean T. Jones, Kaylee L. Mickens, Caitlin Shepard, Axel Roers, Rayk Behrendt, Li Wu, Baek Kim, Mario L. Santiago
Publikováno v:
J Immunol
SAMHD1 is a potent HIV-1 restriction factor that blocks reverse transcription in monocytes, dendritic cells and resting CD4+ T cells by decreasing intracellular dNTP pools. However, SAMHD1 may diminish innate immune sensing and Ag presentation, resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d0664e26e1a329a8ee7377272136e1
https://pubmed.ncbi.nlm.nih.gov/34893529
https://pubmed.ncbi.nlm.nih.gov/34893529