Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Caitlin R. Francis"'
Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The promiscuous GTPase Rab35 has been shown to be involved in many important cellular functions. In this article, Francis et al. illustrate how Rab35 acts as a critical brake to actin remodeling during sprouting angiogenesis and how it is necessary f
Externí odkaz:
https://doaj.org/article/7cd658e5c8614c578965dfc67826fa52
Publikováno v:
bioRxiv
Clathrin-mediated endocytosis (CME) is a process vital to angiogenesis as well as general vascular homeostasis. In pathologies where supraphysiological growth factor signaling underlies disease etiology, such as in diabetic retinopathy and solid tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f85fb72dbe990cc2a22b084a0af720
https://doi.org/10.1101/2023.02.22.529543
https://doi.org/10.1101/2023.02.22.529543
Autor:
Caitlin R. Francis, Erich J. Kushner
Publikováno v:
Angiogenesis. 25(3)
Blood vessels demonstrate a multitude of complex signaling programs that work in concert to produce functional vasculature networks during development. A known, but less widely studied, area of endothelial cell regulation is vesicular trafficking, al
Autor:
Rachael J. Judson, Hayle Kincross, Erich J. Kushner, Amelia M. Webb, Keanna M. Lundy, Caitlin R. Francis, Dawn E. Westhoff, Stryder M. Meadows
Publikováno v:
Microcirculation. 29
OBJECTIVE Despite the absolute requirement of Delta/Notch signaling to activate lateral inhibition during early blood vessel development, many mechanisms remain unclear about how this system is regulated. Our objective was to determine the involvemen
Autor:
Erich J. Kushner, Caitlin R. Francis
Publikováno v:
Microcirculation. 29
ObjectivesMechanisms that govern angiogenesis are paramount to our understanding of how blood vessels are formed embryonically, maintained in adulthood and manifest disease. Akin to transcriptional regulation of endothelial-specific genes, vesicular
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Vascular lumen formation requires the redistribution of intracellular proteins to instruct apicobasal polarity, thereby enforcing maturation of both luminal and basal domains. In the absence of proper apical signaling, lumen formation can
ObjectiveVascular lumen formation requires the redistribution of intracellular proteins to instruct apico-basal polarity, thereby enforcing maturation of both luminal and basal domains. In the absence of proper apical signaling, lumen formation can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::237a00edbfd7dd7d32b98ab30aea71d0
https://doi.org/10.1101/2021.02.15.431296
https://doi.org/10.1101/2021.02.15.431296
Autor:
Amelia M Webb, Caitlin R Francis, Jayson M Webb, Hayle Kincross, Keanna M Lundy, Rachael Judson, Dawn Westhoff, Stryder M Meadows, Erich J Kushner
Despite the absolute requirement of Delta/Notch signaling to activate lateral inhibition during early blood vessel development, many mechanisms remain unclear. Here, we identify EHD2 and EHBP1 as novel regulators of Notch activation in endothelial ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71db970547d96c027e374eec38f75bd0
https://doi.org/10.1101/2020.05.19.104547
https://doi.org/10.1101/2020.05.19.104547