Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Caitlin O'Brien-Ball"'
Autor:
Edward Jenkins, Markus Körbel, Caitlin O’Brien-Ball, James McColl, Kevin Y. Chen, Mateusz Kotowski, Jane Humphrey, Anna H. Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis, David Klenerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
T cells can use TCR on microvilli to interact with peptide-MHC (pMHC) complexes on antigen presenting cells. Here the authors characterise how T cells use microvilli to interrogate reconstituted membranes for pMHC complexes and how this is regulated
Externí odkaz:
https://doaj.org/article/e163cebf0d034cc0b49fca7e959be290
Autor:
Weijian Gong, Nicole Ashman, Erdinc Sezgin, Iztok Urbančič, Caitlin O’Brien-Ball, Falk Schneider, Mai Tuyet Vuong, Edward Jenkins, Christian Eggeling, Ana Filipa L.O.M. Santos, Lisa Schiffelers
Publikováno v:
FEBS Letters. 595:2127-2146
To disentangle the elusive lipid-protein interactions in T-cell activation, we investigate how externally imposed variations in mobility of key membrane proteins (T-cell receptor [TCR], kinase Lck, and phosphatase CD45) affect the local lipid order a
Autor:
Caitlin O'Brien-Ball, Simon J. Davis, David Klenerman, Ana Filipa L.O.M. Santos, Kevin Y. Chen, Anna Lippert, Edward Jenkins, Jemma McBride, Markus Körbel, Nicole Ashman, Aleks Ponjavic
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Despite the success of T cell–redirecting immunotherapies for blood cancers, toxic, off-target side effects prevent their safe application to other diseases. Part of the challenge lies in our incomplete understanding of T cell receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da572062ccf19f99faf634d56f90e823
https://doi.org/10.1073/pnas.2024250118
https://doi.org/10.1073/pnas.2024250118
Autor:
Lukas Sušac, Mai T. Vuong, Christoph Thomas, Sören von Bülow, Caitlin O’Brien-Ball, Ana Mafalda Santos, Ricardo A. Fernandes, Gerhard Hummer, Robert Tampé, Simon J. Davis
Publikováno v:
Cell
The T cell receptor (TCR) expressed by T lymphocytes initiates protective immune responses to pathogens and tumors. To explore the structural basis of how TCR signaling is initiated when the receptor binds to peptide-loaded major histocompatibility c
Autor:
Markus Körbel, Edward Jenkins, James T. McColl, Caitlin O'Brien-Ball, Anna H. Lippert, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis, David Klenerman
Publikováno v:
Biophysical Journal. 121:150a-151a
Autor:
Edward Jenkins, Christian Eggeling, Nicole Ashman, Erdinc Sezgin, Caitlin O’Brien-Ball, Ana Filipa L.O.M. Santos, Falk Schneider, Mai Tuyet Vuong, Iztok Urbančič, Weijian Gong, Lisa Schiffelers
The quest for understanding of numerous vital membrane-associated cellular processes, such as signalling, has largely focussed on the spatiotemporal orchestration and reorganisation of the identified key proteins, including their binding and aggregat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d96beeba6ea57e56fd1f50985d3957c6
https://doi.org/10.1101/2020.12.22.422352
https://doi.org/10.1101/2020.12.22.422352
Autor:
Simon J. Davis, Caitlin O’Brien-Ball
Publikováno v:
Biophys J
The natural peptide-major histocompatibility complex (pMHC) ligand for T cell receptors (TCRs) is inactive from solution yet capable of activating T cells at single-molecule levels when membrane-associated. This distinctive feature stems from the mec
Autor:
Adrian Biddle, Caitlin O’Brien-Ball
Publikováno v:
Developmental biology. 430(2)
During development and throughout adult life, sub-populations of cells exist that exhibit phenotypic plasticity - the ability to differentiate into multiple lineages. This behaviour is important in embryogenesis, is exhibited in a more limited contex