Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Caitlin N Suire"'
Autor:
Caitlin N Suire, Sarah Nainar, Michael Fazio, Adam G Kreutzer, Tara Paymozd-Yazdi, Caitlyn L Topper, Caroline R Thompson, Malcolm A Leissring
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193101 (2018)
Insulin-degrading enzyme (IDE) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which are implicated in skin health and wound healing. Pharmacological inhibitors of IDE administer
Externí odkaz:
https://doaj.org/article/c9bacd82d9a24f8b81a04be777941d36
Autor:
Kelly A Hamilton, Yue Wang, Sophia M Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N Suire, Simonetta Camandola, Robert H Lipsky, Mark P Mattson
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196223 (2018)
Bhlhe40 is a transcription factor that is highly expressed in the hippocampus; however, its role in neuronal function is not well understood. Here, we used Bhlhe40 null mice on a congenic C57Bl6/J background (Bhlhe40 KO) to investigate the impact of
Externí odkaz:
https://doaj.org/article/29b6816178af4788abed0fca4328ae15
Publikováno v:
ACS Applied Materials & Interfaces. 15:3851-3866
Publikováno v:
Cells, Vol 10, Iss 8, p 1959 (2021)
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that are then released into the extracellular space through a merging of the multivesicular body with the plasma membrane. These vesicles are secreted by almost all
Externí odkaz:
https://doaj.org/article/d15863b8b6514619a42d43c016120ce9
Autor:
Malcolm A. Leissring, Carlos M. González-Casimiro, Beatriz Merino, Caitlin N. Suire, Germán Perdomo
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2235 (2021)
Hepatic insulin clearance, a physiological process that in response to nutritional cues clears ~50–80% of circulating insulin, is emerging as an important factor in our understanding of the pathogenesis of type 2 diabetes mellitus (T2DM). Insulin-d
Externí odkaz:
https://doaj.org/article/2ed9adc5568f412c92ed7b56906d51aa
Autor:
SO Abdul-Hay, Caitlin N. Suire, Dennis W. Dickson, Monica K Brizuela, Dongcheul Kang, Tomoko Sahara, Malcolm A. Leissring, Terrone L. Rosenberry, Paul Saftig
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid β-protein (Aβ) and the microtubule-associated protein, tau, and has been genetically linked to late-onset Alzheimer disease (AD). Here, we sought to examine the co
Publikováno v:
Medicinal research reviewsREFERENCES. 42(6)
Extracellular vesicles are membranous particles, ranging from 30 nm to 10 µm in diameter, which are released by nearly all cell types to aid in intercellular communication. These complex vesicles carry a multitude of signaling moieties from their ce
Publikováno v:
Cells
Cells, Vol 10, Iss 1959, p 1959 (2021)
Cells, Vol 10, Iss 1959, p 1959 (2021)
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that are then released into the extracellular space through a merging of the multivesicular body with the plasma membrane. These vesicles are secreted by almost all
Publikováno v:
SLAS Discovery. 23:1060-1069
Glucagon is a vital peptide hormone involved in the regulation of blood sugar under fasting conditions. While the processes underlying glucagon production and secretion are well understood, far less is known about its degradation, which could conceiv
Autor:
Malcolm A. Leissring, Caitlin N. Suire
Publikováno v:
Journal of Experimental Neurology. 2
Alzheimer disease (AD) is a debilitating neurodegenerative disorder characterized by extracellular deposition of the amyloid β-protein (Aβ) and intraneuronal accumulation of the microtubule-associated protein, tau. Despite a wealth of experimental