Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Caitlin M. Tilsed"'
Autor:
Wee Loong Chin, Rachael M. Zemek, Caitlin M. Tilsed, Alistair R. R. Forrest, Vanessa S. Fear, Catherine Forbes, Louis Boon, Anthony Bosco, Belinda B. Guo, Michael J. Millward, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis, Timo Lassmann
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood. Here, we present whole tum
Externí odkaz:
https://doaj.org/article/a6b9ffd96f4e40b6b71f12cbc7e2efb8
Autor:
Caitlin M. Tilsed, M. Lizeth Orozco Morales, Rachael M. Zemek, Brianna A. Gordon, Matthew J. Piggott, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Chemotherapy is included in treatment regimens for many solid cancers, but when administered as a single agent it is rarely curative. The addition of immune checkpoint therapy to standard chemotherapy regimens has improved respons
Externí odkaz:
https://doaj.org/article/604f2ab58dbd40a8bc1286fd39a00ca8
Autor:
Rachael M. Zemek, Wee Loong Chin, Vanessa S. Fear, Ben Wylie, Thomas H. Casey, Cath Forbes, Caitlin M. Tilsed, Louis Boon, Belinda B. Guo, Anthony Bosco, Alistair R. R. Forrest, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Timo Lassmann, W. Joost Lesterhuis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Immune checkpoint blockade (ICB) is partially successful as a cancer therapy. Here using mouse models, the authors transcriptionally monitor responding and non-responding tumours showing that responding tumours were associated with transient IFN-β s
Externí odkaz:
https://doaj.org/article/59cfc35dd0fb4aa0a34e44f36234b216
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chemotherapy has historically been the mainstay of cancer treatment, but our understanding of what drives a successful therapeutic response remains limited. The diverse response of cancer patients to chemotherapy has been attributed principally to di
Externí odkaz:
https://doaj.org/article/e6d00f5ca20546b5b9b062d82fa200d8
Autor:
Nicola Principe, Wayne J. Aston, Danika E. Hope, Caitlin M. Tilsed, Scott A. Fisher, Louis Boon, Ian M. Dick, Wee Loong Chin, Alison M. McDonnell, Anna K. Nowak, Richard A. Lake, Jonathan Chee, Willem Joost Lesterhuis
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA‐4) and the programmed cell death protein 1/ligand 1 (PD-1/PD-L1) are now a treatment option for multiple cancer types. However, as a monotherapy, objective res
Externí odkaz:
https://doaj.org/article/eebc1cc11d8240f49cafed6001ba43c0
Autor:
Caitlin M. Tilsed, Thomas H. Casey, Emma de Jong, Anthony Bosco, Rachael M. Zemek, Joanne Salmons, Graeme Wan, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Willem Joost Lesterhuis
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of
Externí odkaz:
https://doaj.org/article/19eeddb4bf7541cbb0eb578d199bb0ef
Autor:
Nicola Principe, Joel Kidman, Siting Goh, Caitlin M. Tilsed, Scott A. Fisher, Vanessa S. Fear, Catherine A. Forbes, Rachael M. Zemek, Abha Chopra, Mark Watson, Ian M. Dick, Louis Boon, Robert A. Holt, Richard A. Lake, Anna K. Nowak, Willem Joost Lesterhuis, Alison M. McDonnell, Jonathan Chee
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT tha
Externí odkaz:
https://doaj.org/article/14028b32db2541389131a67ac973ccfb
CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy
Autor:
Caitlin M. Tilsed, Nicola Principe, Joel Kidman, Wee Loong Chin, M. Lizeth Orozco Morales, Rachael M. Zemek, Jonathan Chee, Rasa Islam, Vanessa S. Fear, Catherine Forbes, Wayne J. Aston, Maud Jansen, Abha Chopra, Timo Lassmann, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
Cell Reports. 41:111874
Autor:
Rachael M. Zemek, Wee Loong Chin, Vanessa S. Fear, Ben Wylie, Thomas H. Casey, Cath Forbes, Caitlin M. Tilsed, Louis Boon, Belinda B. Guo, Anthony Bosco, Alistair R. R. Forrest, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Timo Lassmann, W. Joost Lesterhuis
Publikováno v:
Nature communications. 13(1)
The biological determinants of the response to immune checkpoint blockade (ICB) in cancer remain incompletely understood. Little is known about dynamic biological events that underpin therapeutic efficacy due to the inability to frequently sample tum
Autor:
Caitlin M, Tilsed, Nicola, Principe, Joel, Kidman, Wee Loong, Chin, M Lizeth, Orozco Morales, Rachael M, Zemek, Jonathan, Chee, Rasa, Islam, Vanessa S, Fear, Catherine, Forbes, Wayne J, Aston, Maud, Jansen, Abha, Chopra, Timo, Lassmann, Anna K, Nowak, Scott A, Fisher, Richard A, Lake, W Joost, Lesterhuis
Publikováno v:
Cell reports. 41(13)
While chemotherapy remains the first-line treatment for many cancers, it is still unclear what distinguishes responders from non-responders. Here, we characterize the chemotherapy-responsive tumor microenvironment in mice, using RNA sequencing on tum