Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Caitlin M Rodriguez"'
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-18 (2019)
Abstract Background Upstream open reading frames (uORFs) initiate translation within mRNA 5′ leaders, and have the potential to alter main coding sequence (CDS) translation on transcripts in which they reside. Ribosome profiling (RP) studies sugges
Externí odkaz:
https://doaj.org/article/eb56c3e028df4b94b8f94b84b8995bc1
Autor:
X. Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C. Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, Tetsuya Akiyama, H. Broder Schmidt, Beryl B. Cummings, David W. Wyatt, Katherine Kurylo, Georgiana Miller, Shila Mekhoubad, Nathan Sallee, Gemechu Mekonnen, Laura Ganser, Jack D. Rubien, Karen Jansen-West, Casey N. Cook, Sarah Pickles, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson, James Shorter, Sua Myong, Eric M. Green, William W. Seeley, Leonard Petrucelli, Aaron D. Gitler
Publikováno v:
Nature. 603:124-130
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1. A major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f758b8c837195288f92794e856595a83
https://doi.org/10.1038/s41586-022-04424-7
https://doi.org/10.1038/s41586-022-04424-7
Autor:
Jill M. Haenfler, Geena Skariah, Caitlin M. Rodriguez, Andre Monteiro da Rocha, Jack M. Parent, Gary D. Smith, Peter K. Todd
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Fragile X Syndrome (FXS) is the most common inherited cause of intellectual disability and autism. It results from expansion of a CGG nucleotide repeat in the 5′ untranslated region (UTR) of FMR1. Large expansions elicit repeat and promoter hyper-m
Externí odkaz:
https://doaj.org/article/51d2a59766964b4fb80cf15d790eed9c
Autor:
Shannon E Wright, Caitlin M Rodriguez, Jeremy Monroe, Jiazheng Xing, Amy Krans, Brittany N Flores, Venkatesha Barsur, Magdalena I Ivanova, Kristin S Koutmou, Sami J Barmada, Peter K Todd
Publikováno v:
Nucleic acids research. 50(15)
CGG repeat expansions in the FMR1 5’UTR cause the neurodegenerative disease Fragile X-associated tremor/ataxia syndrome (FXTAS). These repeats form stable RNA secondary structures that support aberrant translation in the absence of an AUG start cod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45255f7e330a7946680d7a13db7d4bd4
https://pubmed.ncbi.nlm.nih.gov/35904811
https://pubmed.ncbi.nlm.nih.gov/35904811
Autor:
Yu Liu, Michael A. Sutton, Shannon E. Wright, Paymaan Jafar-Nejad, Jill M. Haenfler, Michael G. Kearse, Sami J. Barmada, Jack M. Parent, Peter K. Todd, Amy Krans, Frank Rigo, Marius F. Ifrim, Gary J. Bassell, Caitlin M. Rodriguez, Brittany N. Flores, M. R. Glineburg
Publikováno v:
Nature neuroscience
Repeat-associated non-AUG-initiated translation of expanded CGG repeats (CGG RAN) from the FMR1 5'-leader produces toxic proteins that contribute to neurodegeneration in fragile X-associated tremor/ataxia syndrome. Here we describe how unexpanded CGG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6c94f5e10615b67c6ad307ef2b88ac
https://doi.org/10.1038/s41593-020-0590-1
https://doi.org/10.1038/s41593-020-0590-1
Autor:
X Rosa, Ma, Mercedes, Prudencio, Yuka, Koike, Sarat C, Vatsavayai, Garam, Kim, Fred, Harbinski, Adam, Briner, Caitlin M, Rodriguez, Caiwei, Guo, Tetsuya, Akiyama, H Broder, Schmidt, Beryl B, Cummings, David W, Wyatt, Katherine, Kurylo, Georgiana, Miller, Shila, Mekhoubad, Nathan, Sallee, Gemechu, Mekonnen, Laura, Ganser, Jack D, Rubien, Karen, Jansen-West, Casey N, Cook, Sarah, Pickles, Björn, Oskarsson, Neill R, Graff-Radford, Bradley F, Boeve, David S, Knopman, Ronald C, Petersen, Dennis W, Dickson, James, Shorter, Sua, Myong, Eric M, Green, William W, Seeley, Leonard, Petrucelli, Aaron D, Gitler
Publikováno v:
Nature, vol 603, iss 7899
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1. A major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::821110b3bc35110fc73e4b0933142d1d
https://escholarship.org/uc/item/1062r1nd
https://escholarship.org/uc/item/1062r1nd
Autor:
Caitlin M. Rodriguez, Sophia C. Bechek, Graham L. Jones, Lisa Nakayama, Tetsuya Akiyama, Garam Kim, David E. Solow-Cordero, Stephen M. Strittmatter, Aaron D. Gitler
Publikováno v:
Cell Rep
SummaryGene-based therapeutic strategies to lower ataxin-2 levels are emerging for neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia type 2 (SCA2). To identify additional ways of reducing ataxin-2 levels, we pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df587bcfdfc4b1cdfdefa2f4f418783
https://doi.org/10.1101/2021.12.20.473562
https://doi.org/10.1101/2021.12.20.473562
Autor:
Garam Kim, Lisa Nakayama, Jacob A. Blum, Tetsuya Akiyama, Steven Boeynaems, Meena Chakraborty, Julien Couthouis, Eduardo Tassoni-Tsuchida, Caitlin M. Rodriguez, Michael C. Bassik, Aaron D. Gitler
SummaryAntisense oligonucleotide therapy targeting ATXN2—a gene in which mutations cause neurodegenerative diseases spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis—has entered clinical trials in humans. Additional methods to lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a319e1622a07fa2741db5b13555b5751
https://doi.org/10.1101/2021.12.20.473567
https://doi.org/10.1101/2021.12.20.473567
Autor:
Garam Kim, Lisa Nakayama, Jacob A. Blum, Tetsuya Akiyama, Steven Boeynaems, Meenakshi Chakraborty, Julien Couthouis, Eduardo Tassoni-Tsuchida, Caitlin M. Rodriguez, Michael C. Bassik, Aaron D. Gitler
Publikováno v:
Cell Reports. 41:111508
Mutations in the ataxin-2 gene (ATXN2) cause the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia type 2 (SCA2). A therapeutic strategy using antisense oligonucleotides targeting ATXN2 has entered clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857daeb421296976fa18f865b28b3d22
https://doi.org/10.1016/j.celrep.2022.111508
https://doi.org/10.1016/j.celrep.2022.111508
Publikováno v:
BMC Genomics
BMC Genomics, Vol 20, Iss 1, Pp 1-18 (2019)
BMC Genomics, Vol 20, Iss 1, Pp 1-18 (2019)
Background Upstream open reading frames (uORFs) initiate translation within mRNA 5′ leaders, and have the potential to alter main coding sequence (CDS) translation on transcripts in which they reside. Ribosome profiling (RP) studies suggest that tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e7f31b27e660d0974cc5f1fcffeb95
http://europepmc.org/articles/PMC6528255
http://europepmc.org/articles/PMC6528255