Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Caitlin M Carroll"'
Autor:
Morgan C. Pait, Sarah D. Kaye, Yixin Su, Ashish Kumar, Sangeeta Singh, Stephen C. Gironda, Samantha Vincent, Maria Anwar, Caitlin M. Carroll, James Andy Snipes, Jingyun Lee, Cristina M. Furdui, Gagan Deep, Shannon L. Macauley
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 1, Pp n/a-n/a (2024)
Abstract Brain‐derived extracellular vesicles (EVs) play an active role in Alzheimer's disease (AD), relaying important physiological information about their host tissues. The internal cargo of EVs is protected from degradation, making EVs attracti
Externí odkaz:
https://doaj.org/article/5903d2405b69485391b6d5b52d9d7a03
Autor:
Caitlin M. Carroll, Ruth M. Benca
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 274 (2024)
Alzheimer’s disease (AD) is a neurodegenerative disorder affecting nearly one in nine older adults in the US. This number is expected to grow exponentially, thereby increasing stress on caregivers and health systems. While some risk factors for dev
Externí odkaz:
https://doaj.org/article/3f4f0dbeb8a8446c80dd281f55077ce4
Autor:
John Grizzanti, William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah D. Kaye, Caitlin M. Carroll, Nicholas J. Constantino, Lily J. Deitelzweig, James A. Snipes, Derek Kellar, Emily E. Caesar, Ryan J. Pettit-Mee, Stephen M. Day, Jonathon P. Sens, Noelle I. Nicol, Jasmeen Dhillon, Maria S. Remedi, Drew D. Kiraly, Celeste M. Karch, Colin G. Nichols, David M. Holtzman, Shannon L. Macauley
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-β (Aβ) release, offering a mechanistic link between type 2 diabetes and Alzheimer’s disease (AD). Since the cellular mechanisms governing this relationsh
Externí odkaz:
https://doaj.org/article/62f0275671b24363b2fe41c05f92976d
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Alzheimer’s disease (AD) is the most common form of dementia and affects over 45 million people worldwide. Both type-2-diabetes (T2D), a metabolic condition associated with aging, and disrupted sleep are implicated in the pathogenesis of AD, but ho
Externí odkaz:
https://doaj.org/article/8061969cc5164bfd968d5cce6979e71a
Autor:
Morgan C. Pait, Sarah D Kaye, Yixin Su, Ashish Kumar, Sangeeta Singh, Stephen C Gironda, Samantha Vincent, Maria Anwar, Caitlin M Carroll, J Andy Snipes, Jingyun Lee, Cristina M Furdui, Gagan Deep, Shannon L. Macauley
Publikováno v:
bioRxiv
Brain-derived extracellular vesicles (EVs) play an active role in Alzheimer's disease (AD), relaying important physiological information about their host tissues. Circulating EVs are protected from degradation, making them attractive AD biomarkers. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927e2c17eb42491cadce23f63885118b
https://doi.org/10.1101/2023.03.10.532133
https://doi.org/10.1101/2023.03.10.532133
Autor:
Caitlin M. Carroll, Molly Stanley, Ryan V. Raut, Nicholas J. Constantino, Riley E. Irmen, Anish Mitra, J. Andy Snipes, Marcus E. Raichle, David M. Holtzman, Robert W. Gould, Kenneth T. Kishida, Shannon L. Macauley
The sleep-wake cycle is a master regulator of metabolic and neuronal activity and when altered, can have profound effects on metabolic health and disease. Although consideration is given to how fluctuations in blood glucose affect peripheral physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35d3bee901bafde9f408d36b8c596646
https://doi.org/10.1101/2022.09.15.507967
https://doi.org/10.1101/2022.09.15.507967
Autor:
John Grizzanti, William R. Moritz, Morgan C. Pait, Molly Stanley, Sarah D. Kaye, Caitlin M. Carroll, Nicholas J. Constantino, Lily J. Deitelzweig, Noelle Nicol, James A. Snipes, Derek Kellar, Emily E. Caesar, Jasmeen Dhillon, Maria S. Remedi, Celeste M. Karch, Colin G. Nichols, David M. Holtzman, Shannon L. Macauley
Increased neuronal excitability contributes to amyloid-β (Aβ) production and aggregation in the Alzheimer’s disease (AD) brain. Previous work from our lab demonstrated that hyperglycemia, or elevated blood glucose levels, increased brain excitabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e51d2a743753cd5e0702d87d5f4d275
https://doi.org/10.1101/2022.02.20.481215
https://doi.org/10.1101/2022.02.20.481215
Autor:
Stephen M. Day, Emily E. Caesar, Joseph P. Culver, Timothy E. Orr, Laura A. Cox, Celeste M. Karch, Colin G. Nichols, James A. Snipes, Adam Q. Bauer, Caitlin M. Carroll, Molly Stanley, Maria S. Remedi, John Grizzanti, Thomas E. Mahan, Debra I. Diz, Shannon L. Macauley, Annie R. Bice, Nildris Cruz-Diaz, David M. Holtzman, William Moritz
Hyperexcitability is a defining feature of Alzheimer’s disease (AD), where aberrant neuronal activity is both a cause and consequence of AD. Therefore, identifying novel targets that modulate cellular excitability is an important strategy for treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8d595853b317568a849b574ca5313b
https://doi.org/10.1101/2021.08.11.455969
https://doi.org/10.1101/2021.08.11.455969
Autor:
Caitlin M. Carroll, Richard G. Lee, Xianfeng Wang, Adam E. Mullick, Shannon L. Macauley, Janet K. Sawyer, John S. Parks, Alexander Bashore, Mingxia Liu, Elena Boudyguina, Chia-Chi C. Key
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: The role of hepatocyte Abca1 (ATP binding cassette transporter A1) in trafficking hepatic free cholesterol (FC) into plasma versus bile for reverse cholesterol transport (RCT) is poorly understood. We hypothesized that hepatocyte Abca1 rec
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 11 (2019)
Frontiers in Aging Neuroscience, Vol 11 (2019)
Alzheimer’s disease (AD) is the most common form of dementia and affects over 45 million people worldwide. Both type-2-diabetes (T2D), a metabolic condition associated with aging, and disrupted sleep are implicated in the pathogenesis of AD, but ho