Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Caitlin Lynch"'
Autor:
Caitlin Lynch, Ryan Margolis, Jacob Niebler, Jameson Travers, Srilatha Sakamuru, Tongan Zhao, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xia
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy
Externí odkaz:
https://doaj.org/article/7b65418facff4f5691fc2ac4ec95d239
Autor:
Sydney Stern, Dongdong Liang, Linhao Li, Ritika Kurian, Caitlin Lynch, Srilatha Sakamuru, Scott Heyward, Junran Zhang, Kafayat Ajoke Kareem, Young Wook Chun, Ruili Huang, Menghang Xia, Charles C. Hong, Fengtian Xue, Hongbing Wang
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Cyclophosphamide (CPA) and doxorubicin (DOX) are key components of chemotherapy for triple-negative breast cancer (TNBC), although suboptimal outcomes are commonly associated with drug resistance and/or intolerable side effects. Through an approach c
Externí odkaz:
https://doaj.org/article/1a8ce16626d14dd984fe688ea0acc24d
Autor:
Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Noah Z. Burns, Jin K. Cha, Emily E. Mevers, Jon Clardy, Jason A. Clement, Peter A. Crooks, Gregory D. Cuny, Jake Ganor, Jesus Moreno, Lucas A. Morrill, Elias Picazo, Robert B. Susick, Neil K. Garg, Brian C. Goess, Robert B. Grossman, Chambers C. Hughes, Jeffrey N. Johnston, Madeleine M. Joullie, A. Douglas Kinghorn, David G.I. Kingston, Michael J. Krische, Ohyun Kwon, Thomas J. Maimone, Susruta Majumdar, Katherine N. Maloney, Enas Mohamed, Brian T. Murphy, Pavel Nagorny, David E. Olson, Larry E. Overman, Lauren E. Brown, John K. Snyder, John A. Porco, Fatima Rivas, Samir A. Ross, Richmond Sarpong, Indrajeet Sharma, Jared T. Shaw, Zhengren Xu, Ben Shen, Wei Shi, Corey R.J. Stephenson, Alyssa L. Verano, Derek S. Tan, Yi Tang, Richard E. Taylor, Regan J. Thomson, David A. Vosburg, Jimmy Wu, William M. Wuest, Armen Zakarian, Yufeng Zhang, Tianjing Ren, Zhong Zuo, James Inglese, Sam Michael, Anton Simeonov, Wei Zheng, Paul Shinn, Ajit Jadhav, Matthew B. Boxer, Matthew D. Hall, Menghang Xia, Rajarshi Guha, Jason M. Rohde
Publikováno v:
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)
Externí odkaz:
https://doaj.org/article/9f2975f36dd648f0b92b6e0f2b27c087
Autor:
Sydney Stern, Dongdong Liang, Linhao Li, Ritika Kurian, Caitlin Lynch, Scott Heyward, Ajoke Kareem, Young Chun, Charles Hong, Fengtian Xue, Hongbing Wang
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 98-98 (2021)
ABSTRACT IMPACT: Triple negative breast cancer (TNBC) affects 10-20% of women with breast cancer and is biologically more aggressive than other subtypes. The novel compound we have developed, DL7076, would give clinicians a vital strategy to improve
Externí odkaz:
https://doaj.org/article/eff90bbab36e49628ea8e6aba041e053
Autor:
Caitlin Lynch, Jinghua Zhao, Srilatha Sakamuru, Li Zhang, Ruili Huang, Kristine L. Witt, B. Alex Merrick, Christina T. Teng, Menghang Xia
Publikováno v:
Molecules, Vol 24, Iss 5, p 841 (2019)
The nuclear receptor, estrogen-related receptor alpha (ERRα; NR3B1), plays a pivotal role in energy homeostasis. Its expression fluctuates with the demands of energy production in various tissues. When paired with the peroxisome proliferator-activat
Externí odkaz:
https://doaj.org/article/fedd6995974c44b49a02e2fed6349355
Autor:
Adam Yasgar, Danielle Bougie, Richard T. Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K. Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V. Zakharov, Anton Simeonov
Publikováno v:
ACS Pharmacology & Translational Science. 6:683-701
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59a723a9abf8be939478b0e8e0052826
https://doi.org/10.1021/acsptsci.2c00194
https://doi.org/10.1021/acsptsci.2c00194
Publikováno v:
Cognitive Science. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fea6388ae4dc34a66886fca298485da9
https://doi.org/10.1111/cogs.13264
https://doi.org/10.1111/cogs.13264
Publikováno v:
Current protocolsLiterature Cited. 2(12)
The pregnane X receptor (PXR) is a nuclear receptor found mainly in the liver and intestine, whose main function is to regulate the expression of drug-metabolizing enzymes and transporters. Recently, it has been noted that PXR plays critical roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fa0de4348608c3b012785a34d4ff94
https://pubmed.ncbi.nlm.nih.gov/36469580
https://pubmed.ncbi.nlm.nih.gov/36469580
Autor:
Carol Weyhmuller, Caitlin Lynch, Michael Maglio, Sarah Milligan, Sally Otero, Eileen Sherman, Daniel H Lindao, Brett Gilbert, Fredy Chaparro-Rojas
Publikováno v:
Open Forum Infectious Diseases. 9
Background This presentation will highlight how a multiuse hospital product was determined to be contaminated with Burkholderia cepacia (BCC) in the summer of 2021. The investigation began when there was a cluster of inpatients at one campus with blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48c8d6a070d2a403896d04dc55ad0d10
https://doi.org/10.1093/ofid/ofac492.1051
https://doi.org/10.1093/ofid/ofac492.1051
Autor:
Adam Yasgar, Danielle Bougie, Richard T. Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K. Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Alexey V. Zakharov, Anton Simeonov
Dietary Supplements and Natural Products have minor oversight of their safety and efficacy. We assembled a collection of Dietary Supplements and Natural Products (DSNP) as well as Traditional Chinese Medicinal (TCM) Plant extracts, which were screene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d0816e77d83d9d3888c8bd2dc2d53d6
https://doi.org/10.1101/2022.09.14.507630
https://doi.org/10.1101/2022.09.14.507630
