Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Caitlin L. Grzeskowiak"'
Autor:
Xiaohui Hu, Samuel E. Harvey, Rong Zheng, Jingyi Lyu, Caitlin L. Grzeskowiak, Emily Powell, Helen Piwnica-Worms, Kenneth L. Scott, Chonghui Cheng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Splice isoform switching regulated by the heterogeneous nuclear ribonucleoprotein M (hnRNPM) induces EMT and metastasis. Here, the authors report that AKAP8 is a metastasis suppressor that inhibits the splicing activity of hnRNPM and antagonizes geno
Externí odkaz:
https://doaj.org/article/3e6d53a010c24e5a8bea23bdcf82f99b
Autor:
Samrat T. Kundu, Caitlin L. Grzeskowiak, Jared J. Fradette, Laura A. Gibson, Leticia B. Rodriguez, Chad J. Creighton, Kenneth L. Scott, Don L. Gibbons
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
One of the major causes of cancer-related mortality is represented by metastatic lung cancer. Here the authors characterize the role of TMEM106B in driving metastatic lung adenocarcinoma and suggest that TMEM106B-mediated secretion of cathespin impac
Externí odkaz:
https://doaj.org/article/3eec8884c2534e3ab8b673a78e5f82ba
Autor:
Caitlin L. Grzeskowiak, Samrat T. Kundu, Xiulei Mo, Andrei A. Ivanov, Oksana Zagorodna, Hengyu Lu, Richard H. Chapple, Yiu Huen Tsang, Daniela Moreno, Maribel Mosqueda, Karina Eterovic, Jared J. Fradette, Sumreen Ahmad, Fengju Chen, Zechen Chong, Ken Chen, Chad J. Creighton, Haian Fu, Gordon B. Mills, Don L. Gibbons, Kenneth L. Scott
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
KRAS-driven lung cancers represent an aggressive form of NSCLC. In this study the authors perform an in vivo functional screening and identify GATAD2B as a driver of tumor growth and metastasis in KRAS-driven lung cancer.
Externí odkaz:
https://doaj.org/article/7d3a32362fb643e9a451c28f602e01e5
Autor:
Jacqueline A. French, Elena Cleary, Dennis Dlugos, Gail Farfel, Kathleen Farrell, Barry Gidal, Caitlin L. Grzeskowiak, Rachel Gurrell, Cynthia Harden, Tracy J. Stalvey, Julia Tsai, Elaine C. Wirrell, David Blum, Nathan Fountain
Publikováno v:
Epilepsia. 63:2664-2670
Drug treatment for children with epilepsy should, ideally, be governed by evidence from adequate and well-controlled clinical studies. However, these studies are difficult to conduct, and so direct evidence supporting the informed use of specific dru
Autor:
Kenneth L. Scott, Raju Kucherlapati, Peter J. Park, Gordon B. Mills, Roel G. Verhaak, Chad J. Creighton, Young Won Kim, Nicholas J. Neill, Lixing Yang, Angeliki Pantazi, Oksana Zagorodna, Yiu Huen Tsang, Kathleen Kong, Caitlin L. Grzeskowiak, Turgut Dogruluk, Nicole Villafane, Hengyu Lu
Oncogenic gene fusions drive many human cancers, but tools to more quickly unravel their functional contributions are needed. Here we describe methodology permitting fusion gene construction for functional evaluation. Using this strategy, we engineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26651b4976f9547111e4b95287deb941
https://doi.org/10.1158/0008-5472.c.6508520.v1
https://doi.org/10.1158/0008-5472.c.6508520.v1
Autor:
Kenneth L. Scott, Raju Kucherlapati, Peter J. Park, Gordon B. Mills, Roel G. Verhaak, Chad J. Creighton, Young Won Kim, Nicholas J. Neill, Lixing Yang, Angeliki Pantazi, Oksana Zagorodna, Yiu Huen Tsang, Kathleen Kong, Caitlin L. Grzeskowiak, Turgut Dogruluk, Nicole Villafane, Hengyu Lu
Fusion expression detection by PCR (S1); MET fusion expression and signaling activation by immunoblot and N-terminal partner control assay (S2); NTRK2 fusion expression and signaling activation by immunoblot and N-terminal partner control assay (S3);
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e097e94fededb66de3e31490ebf4a668
https://doi.org/10.1158/0008-5472.22412789.v1
https://doi.org/10.1158/0008-5472.22412789.v1
Autor:
Kenneth L. Scott, Raju Kucherlapati, Peter J. Park, Gordon B. Mills, Roel G. Verhaak, Chad J. Creighton, Young Won Kim, Nicholas J. Neill, Lixing Yang, Angeliki Pantazi, Oksana Zagorodna, Yiu Huen Tsang, Kathleen Kong, Caitlin L. Grzeskowiak, Turgut Dogruluk, Nicole Villafane, Hengyu Lu
Fusion genes and their sequences from TCGA (S1-2); Primers for fusion PCR (S3); BRAF mutants and mutagenesis primers (S4); (q)PCR primers for expression detection (S5); Fusion gene construction efficiency and success rate (S6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8da9b21c7fdb43badcc1079d3d81596
https://doi.org/10.1158/0008-5472.22412786
https://doi.org/10.1158/0008-5472.22412786
Autor:
Samrat T. Kundu, Chad J. Creighton, Jared J. Fradette, Kenneth L. Scott, Caitlin L. Grzeskowiak, Rakhee Bajaj, Don L. Gibbons
Publikováno v:
Oncogene
Summary Non-small cell lung cancer (NSCLC) is the deadliest form of cancer worldwide, due in part to its proclivity to metastasize. Identifying novel drivers of invasion and metastasis holds therapeutic potential for the disease. We conducted a gain-
Autor:
Chonghui Cheng, Caitlin L. Grzeskowiak, Rong Zheng, Kenneth L. Scott, Jingyi Lyu, Xiaohui Hu, Emily Powell, Samuel E. Harvey, Helen Piwnica-Worms
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Alternative splicing has been shown to causally contribute to the epithelial–mesenchymal transition (EMT) and tumor metastasis. However, the scope of splicing factors that govern alternative splicing in these processes remains largely unexplored. H
Autor:
Christina M. Boada, Caitlin L. Grzeskowiak, Scott N. Grossman, Sonya B. Dumanis, Jacqueline A. French
Publikováno v:
Epilepsybehavior : EB. 125
From August 27–28, 2020 the Epilepsy Foundation hosted the Pipeline Conference, exploring emerging issues related to antiepileptic drug and device development. The conference featured epilepsy therapeutic companies and academic laboratories develop