Výsledky vyhledávání - "Caitlin K. Quigley"

Mitochondrial Gene Therapy Augments Mitochondrial Physiology in a Parkinson's Disease Cell Model

Autor: Kristen E. Bergquist, Kathleen M. Schwarz, Patricia A. Trimmer, Shilpa Iyer, Ravindar R. Thomas, Christina M. Papageorge, James P. Bennett, Shaharyar M. Khan, Lisa D. Dunham, Caitlin K. Quigley, Paula M. Keeney, Francisco R. Portell

Publikováno v: Human Gene Therapy. 20:897-907

Neurodegeneration in Parkinson's disease (PD) affects mainly dopaminergic neurons in the substantia nigra, where age-related, increasing percentages of cells lose detectable respiratory activity associated with depletion of intact mitochondrial DNA (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550675f8d4111707ff0569aa964c0aa6
https://doi.org/10.1089/hum.2009.023

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Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression

Autor: Shilpa Iyer, James P. Bennett, Lisa D. Dunham, Ravindar R. Thomas, Francisco R. Portell, Caitlin K. Quigley

Publikováno v: Mitochondrion. 9:196-203

We developed a scalable procedure to produce human mitochondrial transcription factor A (TFAM) modified with an N-terminal protein transduction domain (PTD) and mitochondrial localization signal (MLS) that allow it to cross membranes and enter mitoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cbdc2b1a3b596298d15a36023d9863
https://doi.org/10.1016/j.mito.2009.01.012

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Characterization of CpG island DNA methylation of impairment-related genes in a rat model of cognitive aging

Autor: Rebecca P. Haberman, Michela Gallagher, Caitlin K. Quigley

Publikováno v: Epigenetics

Cognitive abilities, particularly memory formation, vary substantially in the elderly, with some individuals exhibiting dramatic decline with age while others maintain function well into late life. Epigenetic modifications suggest an intriguing mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1c13dea7514f65410d23d57355fc35
https://pubmed.ncbi.nlm.nih.gov/22869088

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Cybrid Models of Parkinson's Disease Show Variable Mitochondrial Biogenesis and Genotype-Respiration Relationships

Autor: Caitlin K. Quigley, Kristen E. Bergquist, Stephanie L. Morton, Paula M. Keeney, James P. Bennett, Lisa D. Dunham

Sporadic Parkinson's disease (sPD) is a nervous system-wide disease that presents with a bradykinetic movement disorder and frequently progresses to include depression and cognitive impairment. Cybrid models of sPD are based on expression of sPD plat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc24c93aa89f601a455181b6773de53e
https://europepmc.org/articles/PMC2783275/

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Recombinant Mitochondrial Transcription Factor A with N-terminal Mitochondrial Transduction Domain Increases Respiration and Mitochondrial Gene Expression in G11778A Leber's Hereditary Optic Neuropathy Cybrid Cells

Autor: Lisa Dunahm, Ravindar R. Thomas, Shilpa Iyer, James Bennett, Caitlin K. Quigley, Francisco R. Portell

Publikováno v: Nature Precedings.

Diseases involving mitochondrial defects usually manifest themselves in high-energy, post-mitotic tissues such as brain, retina, skeletal and cardiac muscle and frequently cause deficiencies in mitochondrial bioenergetics. We have developed a scalabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84983cb0e6e6a461ba8fe3d35d33bb4d
https://doi.org/10.1038/npre.2008.2084.1

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