Sex differences in a double-blind randomized clinical trial with minocycline in treatment-resistant depressed patients: CRP and IL-6 as sex-specific predictors of treatment response

Autor: Giulia Lombardo, Maria Antonietta Nettis, Caitlin Hastings, Zuzanna Zajkowska, Nicole Mariani, Naghmeh Nikkheslat, Courtney Worrell, Daniela Enache, Anna McLaughlin, Melisa Kose, Anna Bogdanova, Luca Sforzini, Anthony J. Cleare, Allan H. Young, Paola Dazzan, Valeria Mondelli, Carmine M. Pariante

Publikováno v: Brain, Behavior, & Immunity - Health, Vol 26, Iss , Pp 100561- (2022)

Background: Inflammation is a well-known risk factor for depression. Specifically, patients who do not respond to antidepressant treatment show higher levels of inflammatory biomarkers compared with responders. Thus, several studies have investigated

Externí odkaz: https://doaj.org/article/e3b28fd5a3d34d8ab59e01f1dd9f3ce9

The interaction between kynurenine pathway, suicidal ideation and augmentation therapy with minocycline in patients with treatment-resistant depression

Autor: Maria Antonietta Nettis, Giulia Lombardo, Caitlin Hastings, Zuzanna Zajkowska, Nicole Mariani, Naghmeh Nikkheslat, Luca Sforzini, Courtney Worrell, Amina Begum, Mollie Brown, Anthony J Cleare, Allan H Young, Carmine M Pariante, Valeria Mondelli

Publikováno v: Journal of Psychopharmacology. :026988112311735

Background and aims: We investigated kynurenine pathway (KP) metabolites levels and their association with suicidal ideation in patients with treatment-resistant depression (TRD) and elevated peripheral inflammation. The effect of antidepressant augm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5d2bba5d167172a2349cd888a32dba8
https://doi.org/10.1177/02698811231173588

Treatment resistant depression and inflammatory gene expression profiles – Investigating the role of childhood trauma

Autor: Courtney Worrell, Annamaria Cattaneo, Clarissa Ferrari, Lorinda Turner, Nicole Mariani, Daniela Enache, Caitlin Hastings, Giulia Lombardo, Anna P. McLaughlin, Maria A. Nettis, Naghmeh Nikkheslat, Zuzanna Zajkowska, Luca Sforzini, Melisa Kose, Nadia Cattane, Nicola Lopizzo, Monica Mazzelli, Linda Pointon, Phillip J. Cowen, Jonathan Cavanagh, Neil A. Harrison, Wayne C. Drevets, Valeria Mondelli, Edward T. Bullmore, Carmine M. Pariante

Publikováno v: Brain, Behavior, and Immunity. 106:33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::792c004e509fb2cc1ad8f65617f1377f
https://doi.org/10.1016/j.bbi.2022.07.111

P292. Sex Differences in a Double-Blind Randomized Clinical Trial With Minocycline in Treatment-Resistant Depressed Patients: CRP and IL-6 as Sex-Specific Predictors of Treatment Response

Autor: Giulia Lombardo, Maria Antonietta Nettis, Caitlin Hastings, Zuzanna Zajkowska, Nicole Mariani, Naghmeh Nikkheslat, Courtney Worrell, Daniela Enache, Anna McLaughlin, Melisa Kose, Luca Sforzini, Anna Bogdanova, Anthony J. Cleare, Allan H. Young, Valeria Mondelli, Carmine M. Pariante

Publikováno v: Biological Psychiatry. 91:S205-S206

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7622a0b023ed0c48ec984f606650918
https://doi.org/10.1016/j.biopsych.2022.02.528

A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Autor: Julia J. Schubert, Mattia Veronese, Tim D. Fryer, Roido Manavaki, Manfred G. Kitzbichler, Maria A. Nettis, Valeria Mondelli, Carmine M. Pariante, Edward T. Bullmore, Federico E. Turkheimer, Dominika Wlazly, Amber Dickinson, Andy Foster, Clare Knight, Claire Leckey, Paul Morgan, Angharad Morgan, Caroline O'Hagan, Samuel Touchard, Shahid Khan, Phil Murphy, Christine Parker, Jai Patel, Jill Richardson, Paul Acton, Nigel Austin, Anindya Bhattacharya, Nick Carruthers, Peter de Boer, Wayne Drevets, John Isaac, Declan Jones, John Kemp, Hartmuth Kolb, Jeff Nye, Gayle Wittenberg, Gareth Barker, Anna Bogdanova, Heidi Byrom, Diana Cash, Annamaria Cattaneo, Daniela Enache, Tony Gee, Caitlin Hastings, Melisa Kose, Giulia Lombardo, Nicole Mariani, Anna McLaughlin, Maria Nettis, Naghmeh Nikkheslat, Carmine Pariante, Karen Randall, Julia Schubert, Luca Sforzini, Hannah Sheridan, Camilla Simmons, Nisha Singh, Federico Turkheimer, Vicky Van Loo, Marta Vicente Rodriguez, Toby Wood, Courtney Worrell, Zuzanna Zajkowska, Brian Campbell, Jan Egebjerg, Hans Eriksson, Francois Gastambide, Karen Husted Adams, Ross Jeggo, Thomas Moeller, Bob Nelson, Niels Plath, Christian Thomsen, Jan Torleif Pederson, Stevin Zorn, Catherine Deith, Scott Farmer, John McClean, Andrew McPherson, Nagore Penandes, Paul Scouller, Murray Sutherland, Mary Jane Attenburrow, Jithen Benjamin, Helen Jones, Fran Mada, Akintayo Oladejo, Katy Smith, Rita Balice-Gordon, Brendon Binneman, James Duerr, Terence Fullerton, Veeru Goli, Zoe Hughes, Justin Piro, Tarek Samad, Jonathan Sporn, Liz Hoskins, Charmaine Kohn, Lauren Wilcock, Franklin Aigbirhio, Junaid Bhatti, Ed Bullmore, Sam Chamberlain, Marta Correia, Anna Crofts, Tim Fryer, Martin Graves, Alex Hatton, Manfred Kitzbichler, Mary-Ellen Lynall, Christina Maurice, Ciara O'Donnell, Linda Pointon, Peter St George Hyslop, Lorinda Turner, Petra Vertes, Barry Widmer, Guy Williams, Jonathan Cavanagh, Alison McColl, Robin Shaw, Erik Boddeke, Alison Baird, Stuart Clare, Phil Cowen, I-Shu (Dante) Huang, Sam Hurley, Simon Lovestone, Alejo Nevado-Holgado, Elena Ribe, Anviti Vyas, Laura Winchester, Madeleine Cleal, Diego Gomez-Nicola, Renzo Mancuso, Hugh Perry, Mara Cercignani, Charlotte Clarke, Alessandro Colasanti, Neil Harrison, Rosemary Murray, Jason O'Connor, Howard Mount

Publikováno v: Biological Psychiatry. Cognitive Neuroscience and Neuroimaging

Background: Immune mechanisms have been implicated in the pathogenesis of depression. Translocator protein (TSPO)–targeted positron emission tomography (PET) has been used to assess neuroinflammation in major depressive disorder. We aimed to 1) tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2204ff869f9b3d8a8b56521d5dd1f9c9
http://hdl.handle.net/11577/3411540