Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Caitlin F Connelly"'
Autor:
Yuichi Ichikawa, Caitlin F Connelly, Alon Appleboim, Thomas CR Miller, Hadas Jacobi, Nebiyu A Abshiru, Hsin-Jung Chou, Yuanyuan Chen, Upasna Sharma, Yupeng Zheng, Paul M Thomas, Hsuiyi V Chen, Vineeta Bajaj, Christoph W Müller, Neil L Kelleher, Nir Friedman, Daniel NA Bolon, Oliver J Rando, Paul D Kaufman
Publikováno v:
eLife, Vol 6 (2017)
The repeating subunit of chromatin, the nucleosome, includes two copies of each of the four core histones, and several recent studies have reported that asymmetrically-modified nucleosomes occur at regulatory elements in vivo. To probe the mechanisms
Externí odkaz:
https://doaj.org/article/24b6ece5ed4441b78cfba5f0e8e8b723
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004427 (2014)
Chromatin accessibility is an important functional genomics phenotype that influences transcription factor binding and gene expression. Genome-scale technologies allow chromatin accessibility to be mapped with high-resolution, facilitating detailed a
Externí odkaz:
https://doaj.org/article/52122d90a349445ea27e8e109e14da11
Autor:
James J. Lee, Nina Ly, Rejani B. Kunjamma, Holly M. Robb, Eric G. Mohler, Janani Sridar, Qi Hao, José Zavala-Solorio, Chunlian Zhang, Ganesh Kolumam, Nick van Bruggen, Caitlin F. Connelly, Carmela Sidrauski
eIF2B is a decameric guanine nucleotide exchange factor (GEF) that is essential for protein synthesis and a key effector of the integrated stress response (ISR). Hypomorphic mutations in any of the eIF2B subunits are associated with Vanishing White M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a2d80061127e97b50c933f8fc1faa9d
https://doi.org/10.1101/2023.05.06.539602
https://doi.org/10.1101/2023.05.06.539602
Autor:
Zachary R. Chalmers, Caitlin F. Connelly, David Fabrizio, Laurie Gay, Siraj M. Ali, Riley Ennis, Alexa Schrock, Brittany Campbell, Adam Shlien, Juliann Chmielecki, Franklin Huang, Yuting He, James Sun, Uri Tabori, Mark Kennedy, Daniel S. Lieber, Steven Roels, Jared White, Geoffrey A. Otto, Jeffrey S. Ross, Levi Garraway, Vincent A. Miller, Phillip J. Stephens, Garrett M. Frampton
Publikováno v:
Genome Medicine, Vol 9, Iss 1, Pp 1-14 (2017)
Abstract Background High tumor mutational burden (TMB) is an emerging biomarker of sensitivity to immune checkpoint inhibitors and has been shown to be more significantly associated with response to PD-1 and PD-L1 blockade immunotherapy than PD-1 or
Externí odkaz:
https://doaj.org/article/fb907a4b3aaf43769173e9ac0018e2eb
Autor:
Siraj M. Ali, Ron Bose, Vincent A. Miller, Kyle Gowen, Caitlin F. Connelly, Garrett M. Frampton, Alexa B. Schrock, Runjun D. Kumar, Jeffrey S. Ross, Yakov Chudnovsky, Rachel L. Erlich, Philip J. Stephens
Publikováno v:
JCO precision oncology. 1
Autor:
Megan M. Maurano, Carmela Sidrauski, Caitlin F. Connelly, Daniel B. Stetson, Jessica M. Snyder, Jorge Henao-Mejia
SummaryMutations in ADAR, the gene that encodes the ADAR1 RNA deaminase, cause numerous human diseases, including Aicardi-Goutières Syndrome (AGS). ADAR1 is an essential negative regulator of the RNA sensor MDA5, and loss of ADAR1 function triggers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ece10fae80f9c77756571503182d69b
https://doi.org/10.1101/2020.11.30.405498
https://doi.org/10.1101/2020.11.30.405498
Autor:
Mohammad Hadigol, Jo Anne Vergilio, Anthony Fratella-Calabrese, Caitlin F. Connelly, Vincent A. Miller, Eric Allan Severson, Kim M. Hirshfield, Jeffrey S. Ross, Mendel Goldfinger, Shakti H. Ramkissoon, Garrett M. Frampton, Gregory Riedlinger, Shridar Ganesan, Siraj M. Ali, Lorna Rodriguez-Rodriguez, Hossein Khiabanian, Julia A. Elvin
Publikováno v:
Blood. 131:2501-2505
TO THE EDITOR: Clonal hematopoiesis of indeterminate potential (CHIP) describes an expansion of hematopoietic stem cells that harbor somatic mutations[1][1][⇓][2][⇓][3][⇓][4]-[5][5] without an underlying hematologic malignancy or definitive mor
Publikováno v:
Frontiers in Genetics, Vol 2 (2011)
Considerable work has been devoted to identifying regions of the human genome that have been subjected to recent positive selection. Although detailed follow-up studies of putatively selected regions are critical for a deeper understanding of human e
Externí odkaz:
https://doaj.org/article/81318b02c4b4414ea4895d1b5f816f04
Autor:
Carmela Sidrauski, Jessica M. Snyder, Megan M. Maurano, Daniel B. Stetson, Caitlin F. Connelly, Jorge Henao-Mejia
Publikováno v:
Immunity
Summary The RNA deaminase ADAR1 is an essential negative regulator of the RNA sensor MDA5, and loss of ADAR1 function triggers inappropriate activation of MDA5 by self-RNAs. Mutations in ADAR, the gene that encodes ADAR1, cause human immune diseases,
Autor:
Ilya G. Serebriiskii, Joshua E. Meyer, Garrett M. Frampton, Christopher H. Lieu, Erica A. Golemis, Elizabeth Handorf, Jeffrey S. Ross, Caitlin F. Connelly, V.A. Miller, Sanjeevani Arora, Justin Newberg, Siraj M. Ali, Matthew Cooke
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Colorectal cancer (CRC) is increasingly appreciated as a heterogeneous disease, with factors such as microsatellite instability (MSI), cancer subsite within the colon versus rectum, and age of diagnosis associated with specific disease course and the