Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Caitlin E O'Brien"'
Autor:
Christopher T. Primiani, Jennifer K. Lee, Caitlin E. O’Brien, May W. Chen, Jamie Perin, Ewa Kulikowicz, Polan Santos, Shawn Adams, Bailey Lester, Natalia Rivera-Diaz, Valerie Olberding, Mark V. Niedzwiecki, Eva K. Ritzl, Christa W. Habela, Xiuyun Liu, Zeng-Jin Yang, Raymond C. Koehler, Lee J. Martin
Publikováno v:
Cells, Vol 12, Iss 20, p 2454 (2023)
The effects of hypothermia on neonatal encephalopathy may vary topographically and cytopathologically in the neocortex with manifestations potentially influenced by seizures that alter the severity, distribution, and type of neuropathology. We develo
Externí odkaz:
https://doaj.org/article/ae0556a118e641cd9a3b614c725aad53
Autor:
Caitlin E. O’Brien, Polan T. Santos, Ewa Kulikowicz, Jennifer K. Lee, Raymond C. Koehler, Lee J. Martin
Publikováno v:
BMC Neuroscience, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Cardiac arrest (CA) is the most common cause of acute neurologic insult in children. Many survivors have significant neurocognitive deficits at 1 year of recovery. Epoxyeicosatrienoic acids (EETs) are multifunctional endogenous li
Externí odkaz:
https://doaj.org/article/0d46fd1242614ee9bd759802457f0258
Autor:
Caitlin E. O'Brien, Polan T. Santos, Ewa Kulikowicz, Shawn Adams, Jennifer K. Lee, Elizabeth A. Hunt, Raymond C. Koehler, Donald H. Shaffner
Publikováno v:
Resuscitation Plus, Vol 8, Iss , Pp 100174- (2021)
Aim: To evaluate an algorithm that uses an end-tidal carbon dioxide (ETCO2) target of ≥ 30 torr to guide specific changes in chest compression rate and epinephrine administration during cardiopulmonary resuscitation (CPR) in paediatric swine. Metho
Externí odkaz:
https://doaj.org/article/a519e390833d428db0318864d5835f4d
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-19 (2018)
Abstract Background Neuronal cell loss contributes to the pathology of acute and chronic neurodegenerative diseases, including Alzheimer’s disease (AD). It remains crucial to identify molecular mechanisms sensitizing neurons to various insults and
Externí odkaz:
https://doaj.org/article/1455bbda538b467fae26095a8c256cf7
Autor:
Shan Meltzer, Joshua A. Bagley, Gerardo Lopez Perez, Caitlin E. O’Brien, Laura DeVault, Yanmeng Guo, Lily Yeh Jan, Yuh-Nung Jan
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 859-866 (2017)
Summary: Disruptions in lipid homeostasis have been observed in many neurodevelopmental disorders that are associated with dendrite morphogenesis defects. However, the molecular mechanisms of how lipid homeostasis affects dendrite morphogenesis are u
Externí odkaz:
https://doaj.org/article/d901711a896c4637ab29b66523841162
Autor:
Nagat El Demerdash, May W. Chen, Caitlin E. O’Brien, Shawn Adams, Ewa Kulikowicz, Lee J. Martin, Jennifer K. Lee
Publikováno v:
Cells, Vol 10, Iss 8, p 2120 (2021)
Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia. We investigated whether chymotrypsin-like proteasome activity
Externí odkaz:
https://doaj.org/article/c04154d1dd004e9086a813a609f2143b
Autor:
Caitlin E. O'Brien, Michael Reyes, Polan T. Santos, Sophia E. Heitmiller, Ewa Kulikowicz, Sapna R. Kudchadkar, Jennifer K. Lee, Elizabeth A. Hunt, Raymond C. Koehler, Donald H. Shaffner
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 19 (2018)
Background The American Heart Association recommends use of physiologic feedback when available to optimize chest compression delivery. We compared hemodynamic parameters during cardiopulmonary resuscitation in which either end‐tidal carbon dioxide
Externí odkaz:
https://doaj.org/article/6746f857bc394c0593e07e46eeea5bb0
Autor:
Polan T. Santos, Caitlin E. O'Brien, May W. Chen, C. Danielle Hopkins, Shawn Adams, Ewa Kulikowicz, Rashmi Singh, Raymond C. Koehler, Lee J. Martin, Jennifer K. Lee
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 20 (2018)
Background Neurological deficits in hypoxic‐ischemic encephalopathy, even with therapeutic hypothermia, are partially attributed to white matter injury. We theorized that proteasome insufficiency contributes to white matter injury. Methods and Resu
Externí odkaz:
https://doaj.org/article/dee25330af5e4d3098c46f1298bf20ca
Publikováno v:
The Journal of cell biology, vol 222, iss 1
Membrane trafficking is essential for sculpting neuronal morphology. The GARP and EARP complexes are conserved tethers that regulate vesicle trafficking in the secretory and endolysosomal pathways, respectively. Both complexes contain the Vps51, Vps5
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Here, three researchers who have recently embarked on careers in cephalopod biology discuss the current state of the field and offer their hopes for the future. Seven major topics are explored: genetics, aquaculture, climate change, welfare, behavior
Externí odkaz:
https://doaj.org/article/b0ce9dd7b46946b3937c1a57f1497717