Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Caitlin D. Lemke"'
Autor:
Yinwen Cheng, Nicholas Borcherding, Ayomide Ogunsakin, Caitlin D. Lemke-Miltner, Katherine N. Gibson-Corley, Anand Rajan, Allen B. Choi, Wattawan Wongpattaraworakul, Carlos H. F. Chan, Aliasger K. Salem, George J. Weiner, Andrean L. Simons
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The Toll-like receptor 8 (TLR8) agonist VTX-2337 (motolimod) is an anti-cancer immunotherapeutic agent that is believed to augment natural killer (NK) and dendritic cell (DC) activity. The goal of this work is to examine the role of TLR8 exp
Externí odkaz:
https://doaj.org/article/d67bc1582e584855affb057717db487d
Autor:
Shakoora A. Sabree, Caitlin D. Lemke-Miltner, Sue E. Blackwell, Chaobo Yin, Aaron Bossler, Kareem Ebeid, Aliasger K. Salem, George J. Weiner
Publikováno v:
Vaccines, Vol 9, Iss 9, p 982 (2021)
Vidutolimod, also known as CMP-001, is a virus-like particle composed of the Qβ bacteriophage coat protein encasing a TLR9 agonist. Vidutolimod injected intratumorally is showing promise in early phase clinical trials based on its ability to alter t
Externí odkaz:
https://doaj.org/article/166b965f36da434991cb4fa3e3371783
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/e11e830f330348c79d5df6ebc16ef1db
Autor:
George J Weiner, Caitlin D Lemke-Miltner, Andrean L Simons, MM Hasibuzzaman, Briana Ibarra, Ishrat Khan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/9bb055443b834cd8af2c0910fb582951
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/67865b221600485da1a80772cfc37edc
Autor:
Yinwen Cheng, Caitlin D Lemke-Miltner, Wattawan Wongpattaraworakul, Carlos H F Chan, Andrean L Simons
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background CMP-001 is a novel Toll-like receptor-9 agonist that consists of an unmethylated CpG-A motif-rich G10 oligodeoxynucleotide (ODN) encapsulated in virus-like particles. In situ vaccination of CMP-001 is believed to activate local tumor-assoc
Externí odkaz:
https://doaj.org/article/c3dc7d83db9b40159de5cdcb3819d943
Autor:
George J. Weiner, Aliasger K. Salem, Sue E. Blackwell, Alicia K. Olivier, Amaraporn Wongrakpanich, Caitlin D. Lemke, Vijaya B. Joshi, Amani Makkouk
Figure S1. Synthesis and characterization of Dox MPs. Figure S2. Dox MPs enhance phagocytosis of A20 by DCs. Figure S3. Dox MPs exert similar effects to soluble Dox in human cell lines. Figure S4. All therapy components are required for maximum effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3841dc716ca8ac0d2cfba4539b1cc6
https://doi.org/10.1158/2326-6066.22537451.v1
https://doi.org/10.1158/2326-6066.22537451.v1
Autor:
George J. Weiner, Aliasger K. Salem, Sue E. Blackwell, Alicia K. Olivier, Amaraporn Wongrakpanich, Caitlin D. Lemke, Vijaya B. Joshi, Amani Makkouk
In situ immunization aims at generating antitumor immune responses through manipulating the tumor microenvironment. On the basis of recent advances in the understanding of antitumor immunity, we designed a three-step approach to in situ immunization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdfc505931d2536c04cefcdcacb5026a
https://doi.org/10.1158/2326-6066.c.6548453.v1
https://doi.org/10.1158/2326-6066.c.6548453.v1
Publikováno v:
Cancer Research. 83:4-4
Humanized mouse models can be useful for in vivo preclinical evaluation of mechanisms underlying cancer immunotherapy. Most such models involve systemic engraftment of immunocompromised mice with human lymphoid and hematopoietic cells, often using no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc11fac5968c98c0cb69dbcef43159a
https://doi.org/10.1158/1538-7445.am2023-4
https://doi.org/10.1158/1538-7445.am2023-4
Autor:
Sue E. Blackwell, Ann M. Miller, Ann Tomanek-Chalkley, Kristen L Coleman, George J. Weiner, Carlos H. F. Chan, Katherine N Gibson-Corely, Caitlin D Lemke-Miltner
Publikováno v:
Ann Surg Oncol
BACKGROUND. The treatment options for patients with peritoneal carcinomatosis (PC) of gastrointestinal and pancreaticobiliary origins are limited. The virus-like particle, CMP-001, composed of the Qβ bacteriophage capsid protein encapsulating a CpG-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899961b5cd75f55d02e51672da2129d0
https://doi.org/10.1245/s10434-020-08591-7
https://doi.org/10.1245/s10434-020-08591-7