Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Caitlin Commins"'
Autor:
Aurelien Lathuiliere, Youhwa Jo, Romain Perbet, Cameron Donahue, Caitlin Commins, Noé Quittot, Zhanyun Fan, Rachel E. Bennett, Bradley T. Hyman
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-13 (2023)
Abstract Background The prion-like propagation of tau in neurodegenerative disorders implies that misfolded pathological tau can recruit the normal protein and template its aggregation. Here, we report the methods for the development of sensitive bio
Externí odkaz:
https://doaj.org/article/fc15df3efa934d16963e5ff8c35d1c47
Autor:
Marta Perez-Rando, Simon Dujardin, Rachel E. Bennett, Caitlin Commins, Tara Nibhanupudy, Bradley T. Hyman
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-10 (2020)
Abstract Recent studies suggest that misfolded tau molecules can be released, and taken up by adjacent neurons, propagating proteopathic seeds across neural systems. Yet critical to understanding whether tau propagation is relevant in pathophysiology
Externí odkaz:
https://doaj.org/article/a89699935efb422bb21f78ff8f7330d3
Autor:
Ana Claudia Amaral, Beatriz G. Perez-Nievas, Michael Siao Tick Chong, Alicia Gonzalez-Martinez, Herminia Argente-Escrig, Sara Rubio-Guerra, Caitlin Commins, Serra Muftu, Bahareh Eftekharzadeh, Eloise Hudry, Zhanyun Fan, Prianca Ramanan, Shuko Takeda, Matthew P. Frosch, Susanne Wegmann, Teresa Gomez-Isla
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102058- (2021)
Summary: It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer
Externí odkaz:
https://doaj.org/article/0834daf1f0d14cb1bd40b2f5ea69e654
Autor:
Bence György, Camilla Lööv, Mikołaj P. Zaborowski, Shuko Takeda, Benjamin P. Kleinstiver, Caitlin Commins, Ksenia Kastanenka, Dakai Mu, Adrienn Volak, Vilmantas Giedraitis, Lars Lannfelt, Casey A. Maguire, J. Keith Joung, Bradley T. Hyman, Xandra O. Breakefield, Martin Ingelsson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 429-440 (2018)
The APPswe (Swedish) mutation in the amyloid precursor protein (APP) gene causes dominantly inherited Alzheimer’s disease (AD) as a result of increased β-secretase cleavage of the amyloid-β (Aβ) precursor protein. This leads to abnormally high A
Externí odkaz:
https://doaj.org/article/02b58cb34d3c4ec3bd5ead3c96a5fabe
Autor:
Sarah L. DeVos, Bianca T. Corjuc, Derek H. Oakley, Chloe K. Nobuhara, Riley N. Bannon, Alison Chase, Caitlin Commins, Jose A. Gonzalez, Patrick M. Dooley, Matthew P. Frosch, Bradley T. Hyman
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Alzheimer's disease (AD) is defined by the presence of intraneuronal neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid-beta plaques. The presence and spread of tau pathology through the bra
Externí odkaz:
https://doaj.org/article/58f471c2d42b4591be836bf11a262f72
Autor:
Samantha B Nicholls, Sarah L DeVos, Caitlin Commins, Chloe Nobuhara, Rachel E Bennett, Diana L Corjuc, Eduardo Maury, Bahareh Eftekharzadeh, Ololade Akingbade, Zhanyun Fan, Allyson D Roe, Shuko Takeda, Susanne Wegmann, Bradley T Hyman
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177914 (2017)
The spread of neurofibrillary tangle (NFT) pathology through the human brain is a hallmark of Alzheimer's disease (AD), which is thought to be caused by the propagation of "seeding" competent soluble misfolded tau. "TauC3", a C-terminally truncated f
Externí odkaz:
https://doaj.org/article/6b7577e645ef4883bb7ef913fa08713d
Autor:
Anastasie Mate de Gerando, Lindsay A Welikovitch, Anita Khasnavis, Caitlin Commins, Calina Glynn, Joshua E Chun, Romain Perbet, Bradley T Hyman
Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in Alzheimer disease. More recent studies have implicated soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f3fa63ff1d4356fbd355dade343809f
https://doi.org/10.1101/2023.03.28.534418
https://doi.org/10.1101/2023.03.28.534418
Autor:
Derek H. Oakley, Caitlin Commins, Matthew P. Frosch, Simon Dujardin, Mirra Chung, Bradley T. Hyman, Rachel E. Bennett, Naomi Klickstein
Publikováno v:
The Journal of Neuroscience
Tau aggregation within neurons is a critical feature of Alzheimer's disease (AD) and related tauopathies. It is believed that soluble pathologic tau species seed the formation of tau aggregates in a prion-like manner and propagate through connected n
Autor:
Simon Dujardin, Analiese Fernandes, Riley Bannon, Caitlin Commins, Mark De Los Santos, Tarun V. Kamath, Mansuo Hayashi, Bradley T. Hyman
Publikováno v:
Brain Communications. 4
Progressive cognitive decline in Alzheimer’s disease correlates closely with the spread of tau protein aggregation across neural networks of the cortical mantle. We tested the hypothesis that heritable factors may influence the rate of propagation
Autor:
Patrick M. Dooley, Bradley T. Hyman, Pia Kivisäkk, James D. Berry, Teresa Gomez-Isla, Tiziana Petrozziello, Steven E. Arnold, Ghazaleh Sadri-Vakili, Bianca A. Trombetta, Ana C. Amaral, James Chan, Tara L. Spires-Jones, Alexandra N. Mills, Derek H. Oakley, Anubrata Ghosal, Caitlin Commins, Merit Cudkowicz, Simon Dujardin, Sali M K Farhan, Theresa R Connors, Evan A. Bordt, Spencer E. Kim
Publikováno v:
Brain pathology (Zurich, Switzerland). 32(2)
Although the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS) are not yet fully understood, several studies report alterations in tau phosphorylation in both sporadic and familial ALS. Recently, we have demonstrated that phosphoryl