Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

Autor: Neal Anthwal, Michelle Pelling, Suzanne Claxton, Georg Mellitzer, Caitlin Collin, Nicoletta Kessaris, William D. Richardson, Gérard Gradwohl, Siew-Lan Ang

Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1133-1145 (2013)

SUMMARY The ventral hypothalamus acts to integrate visceral and systemic information to control energy balance. The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been implicated

Externí odkaz: https://doaj.org/article/5f550611b1a74183bc5fedc179c29251

MOZ directs the distal-less homeobox gene expression program during craniofacial development

Autor: Tim Thomas, Hannah K. Vanyai, Rose E. May, Caitlin Collin, Stephen Wilcox, Helen M. McRae, Anne K. Voss, Alexandra L. Garnham, Gordon K. Smyth

Publikováno v: Development (Cambridge, England). 146(14)

Oral clefts are common birth defects. Individuals with oral clefts who have identical genetic mutations regularly present with variable penetrance and severity. Epigenetic or chromatin-mediated mechanisms are commonly invoked to explain variable pene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559bc688357910854ef583b4e896e668
https://pubmed.ncbi.nlm.nih.gov/31340933

MOZ Regulates the Tbx1 Locus, and Moz Mutation Partially Phenocopies DiGeorge Syndrome

Autor: Caitlin Collin, Mathew P. Dixon, Bilal N. Sheikh, Tamara J. McLennan, Tim Thomas, Peter J. Scambler, Hannah K. Vanyai, Anne K. Voss

Publikováno v: Developmental Cell

Summary DiGeorge syndrome, caused by a 22q11 microdeletion or mutation of the TBX1 gene, varies in severity greatly, even among monozygotic twins. Epigenetic phenomena have been invoked to explain phenotypic differences in individuals of identical ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e93d51f15cbd395eaf9fc5296b2d7be

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

Autor: Kathy Knezevic, Julie Scott, Thomas Bee, Adrienne A. Hilton, Tracy A. Willson, Benjamin T. Kile, Douglas J. Hilton, Tim Thomas, Warren S. Alexander, John E. Pimanda, Samir Taoudi, Anne K. Voss, Caitlin Collin

Publikováno v: Genes & Development. 25:251-262

Although many genes are known to be critical for early hematopoiesis in the embryo, it remains unclear whether distinct regulatory pathways exist to control hematopoietic specification versus hematopoietic stem cell (HSC) emergence and function. Due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5459263dcd57ccd4cf72f8a5aee2ce58
https://doi.org/10.1101/gad.2009211

Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

Autor: William D. Richardson, Gerard Gradwohl, Georg Mellitzer, Caitlin Collin, Suzanne Claxton, Nicoletta Kessaris, Neal Anthwal, Siew-Lan Ang, Michelle Pelling

Publikováno v: Anthwal, N, Pelling, M, Claxton, S, Mellitzer, G, Collin, C, Kessaris, N, Richardson, W D, Gradwohl, G & Ang, S-L 2013, ' Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity ', Disease Models & Mechanisms, vol. 6, no. 5, pp. 1133-1145 . https://doi.org/10.1242/dmm.011916
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1133-1145 (2013)
Disease Models & Mechanisms

SummaryThe ventral hypothalamus acts to integrate visceral and systemic information to control energy balance. The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been implicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61917f4322dc13a37c6c6ebfdc5457d5
https://kclpure.kcl.ac.uk/en/publications/a9f3421f-62a4-417a-9127-eec0c85caf79