Myelodysplastic neoplasm-associated U2AF1 mutations induce host defense defects by compromising neutrophil chemotaxis.

Autor: Gurule NJ; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA.; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.; Department of Immunology and Microbiology, University of Colorado School of Medicine, Anschutz, CO, USA., Malcolm KC; Department of Medicine, National Jewish Health, Denver, CO, USA., Harris C; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA.; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA., Knapp JR; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA., O'Connor BP; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA.; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.; Department of Immunology and Microbiology, University of Colorado School of Medicine, Anschutz, CO, USA., McClendon J; Department of Medicine, National Jewish Health, Denver, CO, USA., Janssen WJ; Department of Medicine, National Jewish Health, Denver, CO, USA.; Department of Medicine, University of Colorado, Aurora, CO, USA., Lee FFY; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA.; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.; Department of Immunology and Microbiology, University of Colorado School of Medicine, Anschutz, CO, USA., Price C; Department of Medicine, University of Colorado, Aurora, CO, USA., Osaghae-Nosa J; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA.; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA., Wheeler EA; Department of Medicine, National Jewish Health, Denver, CO, USA., McMahon CM; Department of Medicine, University of Colorado, Aurora, CO, USA., Pietras EM; Department of Medicine, University of Colorado, Aurora, CO, USA., Pollyea DA; Department of Medicine, University of Colorado, Aurora, CO, USA., Alper S; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA. alpers@njhealth.org.; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA. alpers@njhealth.org.; Department of Immunology and Microbiology, University of Colorado School of Medicine, Anschutz, CO, USA. alpers@njhealth.org.

Publikováno v: Leukemia [Leukemia] 2023 Oct; Vol. 37 (10), pp. 2115-2124. Date of Electronic Publication: 2023 Aug 17.