Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Caitlin Bourque"'
Autor:
Ezra Y. Rosen, Helen H. Won, Youyun Zheng, Emiliano Cocco, Duygu Selcuklu, Yixiao Gong, Noah D. Friedman, Ino de Bruijn, Onur Sumer, Craig M. Bielski, Casey Savin, Caitlin Bourque, Christina Falcon, Nikeysha Clarke, Xiaohong Jing, Fanli Meng, Catherine Zimel, Sophie Shifman, Srusthi Kittane, Fan Wu, Marc Ladanyi, Kevin Ebata, Jennifer Kherani, Barbara J. Brandhuber, James Fagin, Eric J. Sherman, Natasha Rekhtman, Michael F. Berger, Maurizio Scaltriti, David M. Hyman, Barry S. Taylor, Alexander Drilon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The results of the phase 1/2 LIBRETTO-001 clinical trial has recently established the efficacy of the RET inhibitor selpercatinib in RET-driven cancers. Here, the authors characterize the molecular determinants of response and resistance in 72 LIBRET
Externí odkaz:
https://doaj.org/article/c9aadc1f6bbc44acba731c2a7dcb7aef
Autor:
Ezra Y. Rosen, Helen H. Won, Youyun Zheng, Emiliano Cocco, Duygu Selcuklu, Yixiao Gong, Noah D. Friedman, Ino de Bruijn, Onur Sumer, Craig M. Bielski, Casey Savin, Caitlin Bourque, Christina Falcon, Nikeysha Clarke, Xiaohong Jing, Fanli Meng, Catherine Zimel, Sophie Shifman, Srushti Kittane, Fan Wu, Marc Ladanyi, Kevin Ebata, Jennifer Kherani, Barbara J. Brandhuber, James Fagin, Eric J. Sherman, Natasha Rekhtman, Michael F. Berger, Maurizio Scaltriti, David M. Hyman, Barry S. Taylor, Alexander Drilon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/5da51ab03db947f7a3ffd0a6118bb43a
Autor:
Craig J. Ceol, Deborah K. Morrison, Leonard I. Zon, Melissa Kasheta, Caitlin Bourque, Robert L. Kortum, James V. Neiswender
The receptor tyrosine kinase KIT promotes survival and migration of melanocytes during development, and excessive KIT activity hyperactivates the RAS/MAPK pathway and can drive formation of melanomas, most notably of rare melanomas that occur on vola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9703cc6c948eef6af983a3ceddd13662
https://doi.org/10.1158/0008-5472.c.6510162.v1
https://doi.org/10.1158/0008-5472.c.6510162.v1
Autor:
Craig J. Ceol, Deborah K. Morrison, Leonard I. Zon, Melissa Kasheta, Caitlin Bourque, Robert L. Kortum, James V. Neiswender
This file contains Supplementary Figures S1-S9 with accompanying legends. Supplementary Fig. S1 examines the relationship between KIT expression and BRAFV600E mutations in TCGA human melanoma samples. Supplementary Fig. S2 shows the rescue of melanoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0307b9a6fddd3b95f62e590f92256833
https://doi.org/10.1158/0008-5472.22418562.v1
https://doi.org/10.1158/0008-5472.22418562.v1
Autor:
Craig J. Ceol, Deborah K. Morrison, Leonard I. Zon, Melissa Kasheta, Caitlin Bourque, Robert L. Kortum, James V. Neiswender
Supplementary Table S1 and S2 show the BRET50 data for Supplementary Fig. S5A and S6B, respectively. Supplementary Table S3 and S4 show further analyses of the relationship between KIT expression and several clinical parameters of melanoma progressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40cc3038b2b0c05eb4dd86b5d084880
https://doi.org/10.1158/0008-5472.22418559.v1
https://doi.org/10.1158/0008-5472.22418559.v1
Autor:
Qin Tang, John C. Moore, Myron S. Ignatius, Inês M. Tenente, Madeline N. Hayes, Elaine G. Garcia, Nora Torres Yordán, Caitlin Bourque, Shuning He, Jessica S. Blackburn, A. Thomas Look, Yariv Houvras, David M. Langenau
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Direct visualisation of heterogeneous cell populations in live animals has been challenging. Here, the authors optimize cell transplantation into optically clear immune-deficient zebrafish, and use intravital imaging to track and to assess functional
Externí odkaz:
https://doaj.org/article/0c91eceedf1044eca16d9570f08e6ec0
Autor:
David B. Solit, Angela G. Arnold, Mark E. Robson, Diana Mandelker, Michael F. Berger, Shweta S. Chavan, Maksym Misyura, Michael Walsh, Anna Maio, Sarah R. Kane, Karen Cadoo, Yelena Kemel, Preethi Srinivasan, Ying Liu, Jinru Shia, Kenneth Offit, Kelsey Breen, Jennifer Kennedy, Margaret Sheehan, Semanti Mukherjee, Caitlin Bourque, Chaitanya Bandlamudi, Zalak Patel, Maria I. Carlo, Zsofia K. Stadler, Amanda Catchings, Erin E. Salo-Mullen, Arnold J. Markowitz, Barry S. Taylor, Prince Rainier Tejada, Rosalba Sacca, Vanessa Marcell, Alicia Latham, Ozge Ceyhan-Birsoy, Mark T.A. Donoghue, Kimberly Amoroso, Megha Ranganathan
Publikováno v:
JCO Precision Oncology. :455-465
PURPOSE NTHL1 and MSH3 have been implicated as autosomal recessive cancer predisposition genes. Although individuals with biallelic NTHL1 and MSH3 pathogenic variants (PVs) have increased cancer and polyposis risk, risks for monoallelic carriers are
Autor:
Thadeous J Kacmarczyk, Caitlin Bourque, Xihui Zhang, Yanwen Jiang, Yariv Houvras, Alicia Alonso, Doron Betel
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129350 (2015)
Multiplexing samples in sequencing experiments is a common approach to maximize information yield while minimizing cost. In most cases the number of samples that are multiplexed is determined by financial consideration or experimental convenience, wi
Externí odkaz:
https://doaj.org/article/1d3e9dc3694c4785ab23b9e917df7d4a
Autor:
Emily H. Cheng, Stephen B. Solomon, Darren R. Feldman, Ed Reznik, Renzo G. DiNatale, Philip Jonsson, Caitlin Bourque, Jonathan A. Coleman, Mazyar Ghanaat, Chung-Han Lee, Jozefina Casuscelli, Martin H. Voss, Jeremy C. Durack, Maria E. Arcila, Daniel M. Tennenbaum, A. Ari Hakimi, Brandon J. Manley, Robert J. Motzer, James J. Hsieh, Nick Socci, Maria I. Carlo, Almedina Redzematovic, Paul Russo, Kyle A. Blum, Mahyar Kashan, Maria F. Becerra
Publikováno v:
European Urology Focus. 4:986-994
Background Next-generation sequencing (NGS) studies of matched pairs of primary and metastatic tumors in renal cell carcinoma (RCC) have been limited to small cohorts. Objective To evaluate the discordance in somatic mutations between matched primary
Autor:
Ezra Y. Rosen, Helen H. Won, Youyun Zheng, Emiliano Cocco, Duygu Selcuklu, Yixiao Gong, Noah D. Friedman, Ino de Bruijn, Onur Sumer, Craig M. Bielski, Casey Savin, Caitlin Bourque, Christina Falcon, Nikeysha Clarke, Xiaohong Jing, Fanli Meng, Catherine Zimel, Sophie Shifman, Srushti Kittane, Fan Wu, Marc Ladanyi, Kevin Ebata, Jennifer Kherani, Barbara J. Brandhuber, James Fagin, Eric J. Sherman, Natasha Rekhtman, Michael F. Berger, Maurizio Scaltriti, David M. Hyman, Barry S. Taylor, Alexander Drilon
Publikováno v:
Nature communications. 13(1)
The efficacy of the highly selective RET inhibitor selpercatinib is now established in RET-driven cancers, and we sought to characterize the molecular determinants of response and resistance. We find that the pre-treatment genomic landscape does not