Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Caitlin A. Nichols"'
Autor:
Ella Nysetvold, Lauren N. Lopez, Ashley N. Cogell, Henrik Fryk, Nelson D. Pace, Sara Snell Taylor, Joyce Rhoden, Caitlin A. Nichols, Demetris Pillas, Alexander Klein, Teresa Gasalla, Anna Scowcroft
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background Progressive supranuclear palsy (PSP) is a rare neurodegenerative brain disease with rapid progression and currently limited treatment options. A comprehensive understanding of disease progression, management, and healthcare resour
Externí odkaz:
https://doaj.org/article/6e2aa388272d41f587cb0d60a0d93ee8
Autor:
Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.
Externí odkaz:
https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
Autor:
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Publikováno v:
eLife, Vol 6 (2017)
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://doaj.org/article/8eec2bdf4b584beabb46e378e18f1d59
Autor:
Ashton C. Berger, John P. Busanovich, Naomi Curimjee, Hope Wei, Sirano Dhe-Paganon, Jack A. Kosmicki, Meredith S. Brown, Andrew D. Cherniack, Rameen Beroukhim, Galen F. Gao, Brenton R. Paolella, Caitlin A. Nichols, Laura M. Urbanski, William J. Gibson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69932bff7bf9743b48a41cd448c169c1
https://doi.org/10.1038/s41467-020-16399-y
https://doi.org/10.1038/s41467-020-16399-y
Publikováno v:
Molecular Genetics and Metabolism. 135:S73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::265701eca6d5c97cf4bbc6a4628686e6
https://doi.org/10.1016/j.ymgme.2021.11.187
https://doi.org/10.1016/j.ymgme.2021.11.187
Publikováno v:
Molecular Genetics and Metabolism. 132:S77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4986e5021bd703db01ffac989eea4e50
https://doi.org/10.1016/j.ymgme.2020.12.179
https://doi.org/10.1016/j.ymgme.2020.12.179
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:8543-8556
Tissue proteomics has relied heavily on two-dimensional gel electrophoresis, for protein separation and quantification, then single protein isolation, trypsin digestion, and mass spectrometric protein identification. Such methods are predominantly us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9106077b9e9e7c4d325100ea087410e1
https://doi.org/10.1007/s00216-015-9009-3
https://doi.org/10.1007/s00216-015-9009-3
Autor:
Rameen Beroukhim, Aviad Tsherniak, John A. Alberta, Barbara A. Weir, Glenn S. Cowley, Esther A. Obeng, Belinda Wong, Charles D. Stiles, William C. Hahn, Robin Reed, Yong Yu, Benjamin L. Ebert, Meredith Brown, Rebecca Lamothe, Laura M. Urbanski, William J. Gibson, David E. Root, Caitlin A. Nichols, Pratiti Bandopadhayay, Francisca Vazquez, Guo Wei, Peter S. Choi, Travis I. Zack, Brenton R. Paolella
Many pediatric cancers exhibit widespread somatic copy number alterations. We integrated a genome-scale shRNA viability screen and copy number profiles from 179 cancer cell lines to perform an unbiased analysis of copy-number associated gene-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a29da7c1cd9c8eed5c1a43243a02dc9
https://europepmc.org/articles/PMC5474993/
https://europepmc.org/articles/PMC5474993/
Autor:
Benjamin L. Ebert, Belinda Wang, Barbara A. Weir, Pankaj K. Agarwalla, Aviad Tsherniak, Meredith Brown, Charles D. Stiles, Rameen Beroukhim, William J. Gibson, Sara J. Buhrlage, John A. Alberta, William C. Hahn, Guo Wei, Peter S. Choi, Esther A. Obeng, Pratiti Bandopadhayay, Laura M. Urbanski, Caitlin A. Nichols, Glenn S. Cowley, Robin Reed, Brenton R. Paolella, Rebecca Lamothe, Travis I. Zack, Francisca Vazquez, Yong Yu, Dirk Heckl, David E. Root
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac611ac7a7ecb0fa1740892bfad3caf0
https://doi.org/10.7554/elife.23268.025
https://doi.org/10.7554/elife.23268.025
Autor:
Guo Wei, Benjamin L. Ebert, Yong Yu, Travis I. Zack, Sara J. Buhrlage, David E. Root, Pankaj K. Agarwalla, Meredith Brown, Dirk Heckl, Laura M. Urbanski, Peter S. Choi, Barbara A. Weir, Aviad Tsherniak, Esther A. Obeng, Glenn S. Cowley, Robin Reed, Brenton R. Paolella, Pratiti Bandopadhayay, Rameen Beroukhim, John A. Alberta, Rebecca Lamothe, Francisca Vazquez, William J. Gibson, Caitlin A. Nichols, Belinda Wang, Charles D. Stiles, William C. Hahn
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aa0272ca1a43ca064fe0c41c1a8420
https://elifesciences.org/articles/23268
https://elifesciences.org/articles/23268