Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Cait M Costello"'
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Gozde Gencer, Christopher Mancuso, Koon Jiew Chua, Hua Ling, Cait M. Costello, Matthew Wook Chang, John C. March
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Uric acid disequilibrium is implicated in chronic hyperuricemia-related diseases. Long-term monitoring and lowering of serum uric acid levels may be crucial for diagnosis and effective management of these conditions. However, current strategies are n
Externí odkaz:
https://doaj.org/article/53e787221678405391adba56a9c3bee5
Autor:
Cait M. Costello, Graham G. Willsey, Angelene F. Richards, Jaeyoon Kim, Matteo S. Pizzuto, Stefano Jaconi, Fabio Benigni, Davide Corti, Nicholas J. Mantis, John C. March
Publikováno v:
Infect Immun
Secretory IgA (SIgA) is the most abundant antibody type in intestinal secretions where it contributes to safeguarding the epithelium from invasive pathogens like the Gram-negative bacterium, Salmonella enterica serovar Typhimurium (STm). For example,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b68e91306267b4a581b7341d85c5c8a
https://europepmc.org/articles/PMC9202428/
https://europepmc.org/articles/PMC9202428/
Autor:
Bryan Crawford, Cait M. Costello, David J. Hackam, John C. March, Rohan Panaparambil, Laura Y. Martin, Elizabeth Redfield, Adam D. Werts, Blake Johnson, Chhinder P. Sodhi, William B. Fulton, Mitchell R. Ladd, Carolyn Gosztyla
Publikováno v:
Tissue Eng Part A
The goal of this study was to develop a scaffold for the generation of an artificial intestine that specifically mimics the architecture and biomechanical properties of the native small intestine, and to evaluate the scaffold in vitro and in vivo. Sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4921a3126b55d2bf71faf593501bddc
https://doi.org/10.1089/ten.tea.2018.0239
https://doi.org/10.1089/ten.tea.2018.0239
Autor:
Chamini V. Karunaratne, Arne Schön, Iain A. Murray, Michelle C. Neary, Maria Maddalena Cavalluzzi, Matthew R. Redinbo, Adam P. Matson, Bret D. Wallace, Gary H. Perdew, Martina Stepankova, Ryan Balfour Sartor, Eva Jiskrová, Saraswathi Vishveshwara, Shirshendu Chatterjee, Dennis L. Wright, Zdeněk Dvořák, Haiwei Gu, Kyu Shik Mun, John C. March, Simon A. Hirota, Julia Yue Cui, Katherine Sun, Lars U. Nordstroem, Amanda P. Beck, Iveta Iveta Bartonkov, Aneta Vrzalová, Julius Brtko, Barbora Vyhlídalová, Sridhar Mani, Kyle L. Flannigan, Karolína Poulíková, Felix Kopp, Hao Li, Lucia Toporova, Harmit S. Ranhotra, William G. Walton, Cait M. Costello, Sandhya Kortagere, Aneesh Chandran, Giovanni Lentini, Anjaparavanda P. Naren, Jazmin S. Kemp
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine
The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that established m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e9267d258ba26f43500c0c8a143511
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
John C. March, David J. Hackam, Leonard M. Hartmanis, Victor Chen, Marek A. Kwasnica, Mikkel B. Phillipsen, Matthew Wook Chang, William E. Bentley, Cait M. Costello
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
The development of in vitro artificial small intestines that realistically mimic in vivo systems will enable vast improvement of our understanding of the human gut and its impact on human health. Synthetic in vitro models can control specific paramet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827d05be4c1a59cb2ae4fffb32f74aca
http://link.springer.com/article/10.1038/s41598-017-12984-2
http://link.springer.com/article/10.1038/s41598-017-12984-2
Autor:
Jenna L. Dziki, Hongpeng Jia, Chhinder P. Sodhi, Cait M. Costello, David J. Hackam, Maria Quidgley, Shahab Shaffiey, John C. March, Timothy J. Keane, Deena Wasserman, Stephen F. Badylak
Publikováno v:
Regenerative Medicine. 11:45-61
Aims: To investigate the growth and differentiation of intestinal stem cells on a novel tubular scaffold in vitro and in vivo. Materials & methods: Intestinal progenitor cells from mice or humans were cultured with myofibroblasts, macrophages and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb11be73911665e2d3a21e8978e321bb
https://doi.org/10.2217/rme.15.70
https://doi.org/10.2217/rme.15.70
Autor:
Cait M. Costello, Laura Y. Martin, David J. Hackam, Adam D. Werts, William B. Fulton, Chhinder P. Sodhi, John C. March, Mitchell R. Ladd
Publikováno v:
Tissue engineering. Part C, Methods. 24(6)
Short bowel syndrome (SBS) is a major cause of morbidity and mortality in the pediatric population, for which treatment options are limited. To develop novel approaches for the treatment of SBS, we now focus on the development of a tissue-engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191a4e05c9fb23a38401855ff72a7c45
https://pubmed.ncbi.nlm.nih.gov/29638197
https://pubmed.ncbi.nlm.nih.gov/29638197
Publikováno v:
Molecular Pharmaceutics
Biomimetic in vitro intestinal models are becoming useful tools for studying host-microbial interactions. In the past, these models have typically been limited to simple cultures on 2-D scaffolds or Transwell inserts, but it is widely understood that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261fc1a0ad1832bc4a86e32da1c9616a
http://europepmc.org/articles/PMC4096232
http://europepmc.org/articles/PMC4096232
Autor:
Nina K. Jain, John C. March, David J. Hackam, Jia Hongpeng, Jiajie Yu, Shahab Shaffiey, Cait M. Costello
Publikováno v:
Biotechnology and Bioengineering. 111:1222-1232
In vitro intestinal models can provide new insights into small intestinal function, including cellular growth and proliferation mechanisms, drug absorption capabilities, and host-microbial interactions. These models are typically formed with cells cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b872168a4929fdc68f5908c78d315d80
https://doi.org/10.1002/bit.25180
https://doi.org/10.1002/bit.25180