Glucose Transport and Utilization in the Hippocampus: From Neurophysiology to Diabetes-Related Development of Dementia

Autor: Caio Yogi Yonamine, Maria Luiza Estimo Michalani, Rafael Junges Moreira, Ubiratan Fabres Machado

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 22, p 16480 (2023)

The association of diabetes with cognitive dysfunction has at least 60 years of history, which started with the observation that children with type 1 diabetes mellitus (T1D), who had recurrent episodes of hypoglycemia and consequently low glucose sup

Externí odkaz: https://doaj.org/article/6d812b6a6bc84ef1b3a1f2058457efbc

Sympathetic Regulation of Slc2a4 Gene Expression: Participation of a Putative cAMP Responsive Element (CRE) Site in the Slc2a4 Promoter

Autor: Ana Barbara Alves-Wagner, Caio Yogi Yonamine, Luciana Alves de Fatima, William Festuccia, Ubiratan Fabres Machado

Publikováno v: Cellular Physiology and Biochemistry, Vol 52, Iss 3, Pp 580-594 (2019)

Externí odkaz: https://doaj.org/article/588f57e68359487db56636c9b2614721

Postmortem Brains from Subjects with Diabetes Mellitus Display Reduced GLUT4 Expression and Soma Area in Hippocampal Neurons:Potential Involvement of Inflammation

Autor: Caio Yogi Yonamine, Marisa Passarelli, Claudia Kimie Suemoto, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, Venâncio Avancini Ferreira Alves, Suely Kazue Nagahashi Marie, Maria Lucia Correa-Giannella, Luiz Roberto Britto, Ubiratan Fabres Machado

Publikováno v: Yonamine, C Y, Passarelli, M, Suemoto, C K, Pasqualucci, C A, Jacob-Filho, W, Alves, V A F, Marie, S K N, Correa-Giannella, M L, Britto, L R & Machado, U F 2023, ' Postmortem Brains from Subjects with Diabetes Mellitus Display Reduced GLUT4 Expression and Soma Area in Hippocampal Neurons : Potential Involvement of Inflammation ', Cells, vol. 12, no. 9, 1250 . https://doi.org/10.3390/cells12091250
Cells; Volume 12; Issue 9; Pages: 1250

Diabetes mellitus (DM) is an important risk factor for dementia, which is a common neurodegenerative disorder. DM is known to activate inflammation, oxidative stress, and advanced glycation end products (AGEs) generation, all capable of inducing neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e5e8374c0cce85bcb66e7dc470c820
https://curis.ku.dk/ws/files/347816011/Postmortem_Brains.pdf

Diabetes induces tri-methylation at lysine 9 of histone 3 at Slc2a4 gene in skeletal muscle: A new target to improve glycemic control

Autor: Maria Lúcia Corrêa-Giannella, Ubiratan Fabres Machado, Ana Barbara Alves-Wagner, Caio Yogi Yonamine, João Victor Del Conti Esteves, Maristela Mitiko Okamoto, Daniel Giannella-Neto

Publikováno v: Molecular and Cellular Endocrinology. 481:26-34

Expression of the glucose transporter GLUT4, encoded by Slc2a4 gene, is reduced in both type 1 and type 2 diabetes (T1D and T2D), contributing to glycemic impairment. The present study investigated epigenetic regulations at the Slc2a4 promoter in ske

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0909939425160d6d64fbe6017a08e10d
https://doi.org/10.1016/j.mce.2018.11.006

Diabetes Modulates MicroRNAs 29b-3p, 29c-3p, 199a-5p and 532-3p Expression in Muscle: Possible Role in GLUT4 and HK2 Repression

Autor: Frederico Gerlinger-Romero, Caio Yogi Yonamine, Francisco J. Enguita, Ubiratan Fabres Machado, Danilo C. Pinto-Junior, João Victor Del Conti Esteves

Publikováno v: Frontiers in Endocrinology, Vol 9 (2018)

The reduced expression of solute carrier family 2, facilitated glucose transporter member 4 (GLUT4) and hexokinase-2 (HK2) in skeletal muscle participates in insulin resistance of diabetes mellitus (DM). MicroRNAs (miRNAs) have emerged as important m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9daac64b9ce21f01c0af4a0c6aedd89
https://www.frontiersin.org/article/10.3389/fendo.2018.00536/full