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Early postnatal administration of an AAV9 gene therapy is safe and efficacious in CLN3 disease.

Autor: Johnson TB; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States.; Amicus Therapeutics, Cranbury, NJ, United States., Brudvig JJ; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States.; Amicus Therapeutics, Cranbury, NJ, United States., Likhite S; The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Pratt MA; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States., White KA; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States., Cain JT; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States.; Amicus Therapeutics, Cranbury, NJ, United States., Booth CD; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States., Timm DJ; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States., Davis SS; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States., Meyerink B; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States., Pineda R; The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Dennys-Rivers C; The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Kaspar BK; The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Meyer K; The Research Institute at Nationwide Children's Hospital, Columbus, OH, United States., Weimer JM; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, United States.; Amicus Therapeutics, Cranbury, NJ, United States.; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States.

Publikováno v: Frontiers in genetics [Front Genet] 2023 Mar 24; Vol. 14, pp. 1118649. Date of Electronic Publication: 2023 Mar 24 (Print Publication: 2023).

Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.

Autor: Yaeger JDW; Department of Biology, University of South Dakota, Vermillion, South Dakota; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, South Dakota., Krupp KT; Department of Biology, University of South Dakota, Vermillion, South Dakota; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota., Jacobs BM; Department of Biology, University of South Dakota, Vermillion, South Dakota; Texas Christian University School of Medicine, Fort Worth, Texas., Onserio BO; Department of Biology, University of South Dakota, Vermillion, South Dakota., Meyerink BL; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, South Dakota., Cain JT; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, South Dakota., Ronan PJ; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, South Dakota., Renner KJ; Department of Biology, University of South Dakota, Vermillion, South Dakota; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota., DiLeone RJ; Division of Molecular Psychiatry, Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut., Summers CH; Department of Biology, University of South Dakota, Vermillion, South Dakota; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; Veterans Affairs Research Service, Sioux Falls VA Health Care System, Sioux Falls, South Dakota. Electronic address: cliff@usd.edu.

Publikováno v: Biological psychiatry [Biol Psychiatry] 2022 May 01; Vol. 91 (9), pp. 841-852. Date of Electronic Publication: 2022 Jan 19.

Age and Sex Influence Mitochondria and Cardiac Health in Offspring Exposed to Maternal Glucolipotoxicity.

Autor: Louwagie EJ; University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA.; Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA., Larsen TD; Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA., Wachal AL; Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA., Gandy TCT; Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA., Eclov JA; Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA., Rideout TC; Department of Exercise and Nutrition Sciences, State University of New York, Buffalo, NY 14214, USA., Kern KA; Department of Exercise and Nutrition Sciences, State University of New York, Buffalo, NY 14214, USA., Cain JT; Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA., Anderson RH; University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA.; Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA., Mdaki KS; Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA., Baack ML; University of South Dakota Sanford School of Medicine, Sioux Falls, SD 57105, USA.; Environmental Influences on Health and Disease Group, Sanford Research, Sioux Falls, SD 57104, USA.; Boekelheide Neonatal Intensive Care Unit, Sanford Children's Hospital, Sioux Falls, SD 57117, USA.

Publikováno v: IScience [iScience] 2020 Oct 28; Vol. 23 (11), pp. 101746. Date of Electronic Publication: 2020 Oct 28 (Print Publication: 2020).