Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Cailen M McCloskey"'
Autor:
Cailen M McCloskey, Ryan Poplin, Nicholas Chim, Ivan Grubisic, Qingfeng Li, Esau Medina, John C. Chaput, Eric J. Yik, Arlene K. Ngor, Lance Co Ting Keh
Publikováno v:
ACS synthetic biology. 10(11)
Synthetic genetic polymers (xeno-nucleic acids, XNAs) have the potential to transition aptamers from laboratory tools to therapeutic agents, but additional functionality is needed to compete with antibodies. Here, we describe the evolution of a biolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e724282d90405f1637e67edd85fce913
https://pubmed.ncbi.nlm.nih.gov/34739228
https://pubmed.ncbi.nlm.nih.gov/34739228
Publikováno v:
ACS synthetic biology. 9(11)
DNA has become a popular soft material for low energy, high-density information storage, but it is susceptible to damage through oxidation, pH, temperature, and nucleases in the environment. Here, we describe a new molecular chemotype for data archiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ab1364df522f8bbef9039f511b0d8b
https://pubmed.ncbi.nlm.nih.gov/32966745
https://pubmed.ncbi.nlm.nih.gov/32966745
Publikováno v:
Journal of the American Chemical Society. 142(17)
Aptamers are often prone to nuclease digestion, which limits their utility in many biomedical applications. Here we describe a xeno-nucleic acid system based on α-l-threofuranosyl nucleic acid (TNA) that is completely refractory to nuclease digestio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d5355b2e3344b399cba01831e23cff
https://pubmed.ncbi.nlm.nih.gov/32298104
https://pubmed.ncbi.nlm.nih.gov/32298104
Publikováno v:
ACS synthetic biology. 8(2)
Ligases are a class of enzymes that catalyze the formation of phosphodiester bonds between an oligonucleotide donor with a 5' terminal phosphate and an oligonucleotide acceptor with a 3' terminal hydroxyl group. Here, we wished to explore the substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bff0a6f148a9f4d80eadfdd0562b2b1
https://pubmed.ncbi.nlm.nih.gov/30629885
https://pubmed.ncbi.nlm.nih.gov/30629885
Autor:
Randi M. Jimenez, Christopher Switzer, Saikat Bala, Yajun Wang, Hui Mei, John C. Chaput, Cailen M McCloskey, Jen-Yu Liao
Publikováno v:
Journal of the American Chemical Society. 140(17)
In vitro selection experiments carried out on artificial genetic polymers require robust and faithful methods for copying genetic information back and forth between DNA and xeno-nucleic acids (XNA). Previously, we have shown that Kod-RI, an engineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d742ea9b226c1bdb2853bfac8515e8fa
https://pubmed.ncbi.nlm.nih.gov/29667819
https://pubmed.ncbi.nlm.nih.gov/29667819