Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Caila Ryan"'
Autor:
Meredith A. Morgan, Yuanyuan Ma, Zaneta Nikolovska-Coleska, Yi Sun, Qiang Zhang, Caila Ryan, Ahmed S.A. Mady, Theodore S. Lawrence
Publikováno v:
Nucleic Acids Research
FBXW7, a classic tumor suppressor, is a substrate recognition subunit of the Skp1-cullin-F-box (SCF) ubiquitin ligase that targets oncoproteins for ubiquitination and degradation. We recently found that FBXW7 is recruited to DNA damage sites to facil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b63ebae3f408bc53cc27c5a05f0b13
https://doi.org/10.1093/nar/gkz058
https://doi.org/10.1093/nar/gkz058
Autor:
Anthony Shilati, Didi Zha, Alexander Kazmer, Noah W. Birch, Alisha Blake, Carson Meredith Nestler, Caila Ryan, Marc A. Morgan, Ali Shilatifard, Lu Wang, Zibo Zhao, Emily J. Rendleman, Patrick A. Ozark
Publikováno v:
Nature cancer. 2(5)
Mutations of ASXL1, encoding a component of the BAP1 histone H2A deubiquitinase complex, occur in human myeloid neoplasms and are uniformly associated with poor prognosis. However, the precise molecular mechanisms through which ASXL1 mutations alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ceaf8c3791edb81aa96c9a63567d34a
https://pubmed.ncbi.nlm.nih.gov/35122023
https://pubmed.ncbi.nlm.nih.gov/35122023
Autor:
Patrick A. Ozark, Didi Zha, Lu Wang, Caila Ryan, Fei Xavier Chen, Michal Ugarenko, Kaixiang Cao, Ali Shilatifard, Christie C. Sze, Emily J. Rendleman, Stacy A. Marshall, Delphine Douillet, Siddhartha Das
Publikováno v:
Science Advances
The COMPASS family members Set1A, Set1B, and Mll2 differentially regulate H3K4me3 peak breadth in embryonic stem cells.
Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residu
Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef7e19965cb55996524642c66465b32
https://doi.org/10.1126/sciadv.aaz4764
https://doi.org/10.1126/sciadv.aaz4764
Autor:
Natalia Khaltyan, Andrea Piunti, David C. Murray, Serdar E. Bulun, Edwin R. Smith, Michal Ugarenko, Jeffrey N. Savas, Marc A. Morgan, Emily J. Rendleman, Ryan Rickels, Bahar D. Yilmaz, Kathryn A. Helmin, Ali Shilatifard, Caila Ryan, Benjamin D. Singer
Publikováno v:
Science Advances
CATACOMB is a catalytic antagonist PRC2 subunit whose expression is induced upon DNA demethylation.
Using biochemical characterization of fusion proteins associated with endometrial stromal sarcoma, we identified JAZF1 as a new subunit of the Nu
Using biochemical characterization of fusion proteins associated with endometrial stromal sarcoma, we identified JAZF1 as a new subunit of the Nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66e1d5587dc742dc9cb43a13e99220f
https://doi.org/10.1126/sciadv.aax2887
https://doi.org/10.1126/sciadv.aax2887
Autor:
Jeffrey N. Savas, Elizabeth T. Bartom, Lu Wang, Caila Ryan, Zibo Zhao, Ali Shilatifard, Navdeep S. Chandel, Stacy A. Marshall, Anthony Shilati, Emily J. Rendleman
Publikováno v:
Science Advances
Zic family proteins regulate GLUT1 gene expression in a β-catenin/Tcf7l2–dependent manner in colorectal cancer cells.
The zinc finger of the cerebellum (ZIC) proteins has been implicated to function in normal tissue development. Recent studie
The zinc finger of the cerebellum (ZIC) proteins has been implicated to function in normal tissue development. Recent studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481caa9166812bcd1b92f75a60d6179c
https://doi.org/10.1126/sciadv.aax0698
https://doi.org/10.1126/sciadv.aax0698
Autor:
Elizabeth T. Bartom, Delphine Douillet, Caila Ryan, Kaixiang Cao, Zibo Zhao, Benjamin D. Singer, Edwin R. Smith, Emily J. Rendleman, Michal Ugarenko, Christie C. Sze, Andrea Piunti, Avani P. Shah, Ali Shilatifard, Kathryn A. Helmin, Marc A. Morgan, Stacy A. Marshall, Didi Zha
Publikováno v:
Nat Genet
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
The COMPASS protein family catalyzes histone H3 lysine 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates H3K4 on many developmental genes and bivalent clusters. To understand MLL2-dependent tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118176e70e10c9108b28c520d9f7f760
https://pubmed.ncbi.nlm.nih.gov/32393859
https://pubmed.ncbi.nlm.nih.gov/32393859
Autor:
Natalia Khaltyan, Emily J. Rendleman, David C. Murray, Marc A. Morgan, Michal Ugarenko, Serdar E. Bulun, Kathryn A. Helmin, Jeffrey N. Savas, Caila Ryan, Edwin R. Smith, Benjamin D. Singer, Andrea Piunti, Bahar D. Yilmaz, Ryan Rickels, Ali Shilatifard
Publikováno v:
Cancer Research. 80:B46-B46
Dysregulation of Polycomb Repressive Complex 2 (PRC2) function is a common feature of many cancer types, including both solid and hematologic malignancies. A number of chromosomal translocations involving Polycomb group proteins have been identified;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d830e5b3a493161221e88944eb9363ca
https://doi.org/10.1158/1538-7445.pedca19-b46
https://doi.org/10.1158/1538-7445.pedca19-b46
Autor:
Zibo Zhao, Andrea Piunti, Lu Wang, Ali Shilatifard, Lihua Zou, Emily J. Rendleman, Patrick A. Ozark, Stacy A. Marshall, Edwin R. Smith, Kathryn A. Helmin, Marc A. Morgan, Caila Ryan, Benjamin D. Singer, Anna L. Whelan
Publikováno v:
Science Advances
An epigenetic axis directs a transcriptional program via enhancer activation by MLL3 COMPASS and TET2-dependent DNA demethylation.
The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytos
The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6ab335aa3f77274cd0e565388ef435
http://europepmc.org/articles/PMC6221537
http://europepmc.org/articles/PMC6221537
Autor:
Meredith A. Morgan, David Karnak, Caila Ryan, Mary A. Davis, Kyle C. Cuneo, Joshua Parcels, Leslie A. Parcels, Theodore S. Lawrence, Jonathan Maybaum, Na Liu
Publikováno v:
International journal of radiation oncology, biology, physics. 95(2)
Purpose Wee1 kinase inhibitors are effective radiosensitizers in cells lacking a G 1 checkpoint. In this study we examined the potential effect of Wee1 kinase inhibition on inducing replication stress in hepatocellular carcinoma (HCC). Methods and Ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ae7fc7f8947e95b4ca9bc2c5c7b961
https://pubmed.ncbi.nlm.nih.gov/26975930
https://pubmed.ncbi.nlm.nih.gov/26975930