Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Caihu Huang"'
Autor:
Jianfeng He, Caihu Huang, Yanmin Guo, Rong Deng, Lian Li, Ran Chen, Yanli Wang, Jian Huang, Junke Zheng, Xian Zhao, Jianxiu Yu
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 580-605 (2024)
Homologous recombination (HR) repair for DNA double‐strand breaks (DSBs) is critical for maintaining genome stability and conferring the resistance of tumor cells to chemotherapy. Nuclear PTEN which contains both phosphatidylinositol 3,4,5‐trisph
Externí odkaz:
https://doaj.org/article/f277e1ff74bb4e799df39db79db3e387
Autor:
Runhui Lu, Yafan Zhang, Ran Chen, Lian Li, Caihu Huang, Zihan Zhou, Yingting Cao, Hongyan Li, Junya Li, Yixin Zhang, Yanli Wang, Jian Huang, Xian Zhao, Jing Feng, Jianxiu Yu, Chunling Du
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 59, Iss , Pp 101082- (2025)
The KRAS/ERK pathway is crucial in cancer progression and chemotherapy resistance, yet its upstream regulatory mechanism remains elusive. We identified MSI2 as a new promoter of chemotherapy resistance in cancers. MSI2 directly binds to a specific cl
Externí odkaz:
https://doaj.org/article/f327cd41a7134e4dafa9e8d3e381f497
Autor:
Xiaojia Liu, Runhui Lu, Qianqian Yang, Jianfeng He, Caihu Huang, Yingting Cao, Zihan Zhou, Jiayi Huang, Lian Li, Ran Chen, Yanli Wang, Jian Huang, Ruiyu Xie, Xian Zhao, Jianxiu Yu
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 170-189 (2024)
Endoribonuclease DICER is an RNase III enzyme that mainly processes microRNAs in the cytoplasm but also participates in nuclear functions such as chromatin remodelling, epigenetic modification and DNA damage repair. The expression of nuclear DICER is
Externí odkaz:
https://doaj.org/article/08e7cbeac8cb4d8e967a197af94d9b90
Autor:
Xian Zhao, Yingting Cao, Runhui Lu, Zihan Zhou, Caihu Huang, Lian Li, Jiayi Huang, Ran Chen, Yanli Wang, Jian Huang, Jinke Cheng, Junke Zheng, Yujie Fu, Jianxiu Yu
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Non‐small‐cell lung cancer (NSCLC) is a highly lethal tumor that often develops resistance to targeted therapy. It is shown that Tank‐binding kinase 1 (TBK1) phosphorylates AGO2 at S417 (pS417‐AGO2), which promotes NSCLC progression
Externí odkaz:
https://doaj.org/article/b52bb434766f4888b2363bcc83ae8ad5
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabo
Externí odkaz:
https://doaj.org/article/1c6b28f5021e45b38d8fd7aec4254bdf
Autor:
Hailong Zhang, Xian Zhao, Yanmin Guo, Ran Chen, Jianfeng He, Lian Li, Zhe Qiang, Qianqian Yang, Xiaojia Liu, Caihu Huang, Runhui Lu, Jiayu Fang, Yingting Cao, Jiayi Huang, Yanli Wang, Jian Huang, Guo-Qiang Chen, Jinke Cheng, Jianxiu Yu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Met1-linked linear ubiquitination (M1-Ubi) is catalyzed by linear ubiquitin chain assembly complex (LUBAC). Here the authors show that Ago2 protein is M1-Ubi modified by LUBAC complex under hypoxia condition leading to less association of miRNA targe
Externí odkaz:
https://doaj.org/article/8322c7884bf545219a1b04b3f0a7aff7
Autor:
Jiayu Fang, Yuqin Zhang, Caihu Huang, Runhui Lu, Jie Yu, Ran Chen, Yanli Wang, Xian Zhao, Jianxiu Yu, Jian Huang
Publikováno v:
Oncogene. 42:1058-1071
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::045b67bdecdf54a510493a16fa9b97f2
https://doi.org/10.1038/s41388-023-02622-9
https://doi.org/10.1038/s41388-023-02622-9
Autor:
Jianfeng He, Yanmin Guo, Rong Deng, Lian Li, Caihu Huang, Ran Chen, Yanli Wang, Jian Huang, Jinke Cheng, Guo-Qiang Chen, Junke Zheng, Xian Zhao, Jianxiu Yu
Homologous recombination (HR) repair for DNA double-strand breaks (DSBs) is critical for maintaining genome stability and cell survival. Nuclear PTEN plays a key role in HR repair, but the underlying mechanism remains largely elusive. We find that SU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89b4b298d657e07b4716b5e0542147a8
https://doi.org/10.1101/2023.02.06.527258
https://doi.org/10.1101/2023.02.06.527258
Autor:
Yanmin Guo, Jianfeng He, Hailong Zhang, Ran Chen, Lian Li, Xiaojia Liu, Caihu Huang, Zhe Qiang, Zihan Zhou, Yanli Wang, Jian Huang, Xian Zhao, Junke Zheng, Guo-Qiang Chen, Jianxiu Yu
Publikováno v:
Oncogene. 41(44)
PTEN is frequently mutated in human cancers, which leads to the excessive activation of PI3K/AKT signaling and thus promotes tumorigenesis and drug resistance. Metsup1/sup-linked ubiquitination (M1-Ubi) is also involved in cancer progression, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5ad308bacffe1ab85631ca1f03f3e5
https://pubmed.ncbi.nlm.nih.gov/36192478
https://pubmed.ncbi.nlm.nih.gov/36192478
Autor:
Yingting Cao, Jianfeng He, Yanmin Guo, Jiayi Huang, Xian Zhao, Runhui Lu, Guo-Qiang Chen, Ran Chen, Hailong Zhang, Jian Huang, Xiaojia Liu, Jianxiu Yu, Zhe Qiang, Jinke Cheng, Qianqian Yang, Lian Li, Caihu Huang, Jiayu Fang, Yanli Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ce600cfd403a14a456d0476430e40e
https://doi.org/10.1038/s41467-021-25739-5
https://doi.org/10.1038/s41467-021-25739-5