Comparative safety assessments of the biosimilar APZ001 and Erbitux in pre-clinical animal models

Autor: Yuankeng Huang, Wang Xiaofei, Wei Yang, Caiguo Ye, Jianmin Guo, Deng Xinyu, Huiqing Liang, Junhua Rao

Publikováno v: Acta Cirurgica Brasileira, Vol 33, Iss 8, Pp 690-702 (2018)
Acta Cirúrgica Brasileira v.33 n.8 2018
Acta Cirúrgica Brasileira
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
Acta Cirurgica Brasileira, Volume: 33, Issue: 8, Pages: 690-702, Published: AUG 2018

Purpose: To evaluate the toxicity of Erbitux as well as its biosimilar APZ001 antibody (APZ001) in pre-clinical animal models including mice, rabbits and cynomolgus monkeys. Methods: We performed analysis of normal behavior activity, autonomic and no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9ae355aaef796e4ab4fb63024cd08f
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502018000800690&tlng=en

Knockdown of TWIST enhances the cytotoxicity of chemotherapeutic drugs in doxorubicin-resistant HepG2 cells by suppressing MDR1 and EMT

Autor: Xiu-Juan Zhang, Hong-Ying Liang, Chun-Yan Lin, Yinghai Zhao, Rong Li, Caiguo Ye, Changli Wu

Publikováno v: International journal of oncology. 53(4)

The transcription factor twist family bHLH transcription factor 1 (TWIST), which is a member of the basic helix-loop-helix class of proteins, is known to induce epithelial-mesenchymal transition (EMT) and promote cancer metastasis. TWIST has previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1124a22b7ee843eabddeeff6ba22678
https://pubmed.ncbi.nlm.nih.gov/30066890

[Inhibitory effect of bispecific antibody targeting IL-12 p40 and TNF-α simultaneously on psoriasis in mice]

Autor: Pin, Xu, Ni, Xie, Caiguo, Ye

Publikováno v: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 33(7)

Objective To construct bispecific antibodies, which can block interleukin 12 (IL-12)/IL-23 p40 subunit and tumor necrosis factor α (TNF-α) simultaneously, and identify their biological function and inhibitory effect on psoriasis formation in mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a3532d4d3c84ea00333237e1de7884c
https://pubmed.ncbi.nlm.nih.gov/28712395

Huangqin-tang ameliorates dextran sodium sulphate-induced colitis by regulating intestinal epithelial cell homeostasis, inflammation and immune response

Autor: Caiguo Ye, Zhiwei He, Honggang Chi, Xuebao Zheng, Jian-Tao Lin, Wen-Yang Li, Congcong Ding, Guoliang Huang, Jian Wang, Xiaoyan Cheng, Zhu-Guo Wu, Ying Zou

Publikováno v: Scientific Reports

Huangqin-tang (HQT) is a traditional Chinese medicine (TCM) formula widely used for the treatment of inflammatory bowel disease in China. However, the molecular mechanisms by which HQT protects the colon are unclear. We studied the protective effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb2bc0cc8da1ffe09a9fc3d1996ef00
http://europepmc.org/articles/PMC5159883

The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression

Autor: Zhiwei He, Ying Zou, Takafumi Uchida, Jian Wang, Hua Chen, Zhu Zhu, Liyong Chen, Weilong Liu, Zigang Dong, Tong Li, Binbin Li, Guo Liang Huang, Caiguo Ye, Dan Liao, Yan Lu, Huahui Li

Publikováno v: Cell Death & Disease

The function of activating transcription factor 1 (ATF1) and the mechanism about why ATF1 was over-phosphorylated in nasopharyngeal carcinoma (NPC) progression is completely undiscovered. In this study, a series of experiments both in vitro and in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7be5a04f291ad74c7bea45badcb7305
http://europepmc.org/articles/PMC5260992