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PTP1B inhibitors: Synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold

Autor: Larry Jang, Xianfeng Li, M. Nuria De Francisco, Steven W. Ferla, J. Russell Grove, Siqun Zhou, Jennifer D. Irvine, Yijun Pan, Caiding Xu, Joy A. Miguel, Natalie Macher, Ashok Bhandari, Christopher P. Holmes, Claire M. Moody, Brian Troy Frederick

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:2719-2724

We have synthesized and evaluated a series of triaryl sulfonamide-based PTP1B inhibitors in which a difluoro-methylenephosphonate group of a potent lead has been replaced by potential bioisosteric replacements. Several mono- or di-charged compounds (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b2e335bf814e75cabe54aa2bb86c94
https://doi.org/10.1016/j.bmcl.2008.03.007

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A general solid phase synthesis of 4-substituted quinolinones via Pd-catalyzed cross coupling

Autor: Ashok Bhandari, Caiding Xu, Christopher P. Holmes, Lydie Yang

Publikováno v: Tetrahedron Letters. 47:4885-4888

A general method for the solid phase synthesis of 4-hydroxy quinolinones and subsequent Pd-catalyzed cross coupling to afford 4-substituted quinolinones has been developed. Conversion of support-bound 4-hydroxy quinolinones to 4-tosyl quinolinones an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e87fae33a527df56bf172056388d21a
https://doi.org/10.1016/j.tetlet.2006.05.032

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Catalytic and selective conversion of (Z)-2-en-4-ynoic acids to either 2H-pyran-2-ones in the presence of ZnBr2 or (Z)-5-alkylidenefuran-2(5H)-ones in the presence of Ag2CO3

Autor: Luigi Anastasia, Ei-ichi Negishi, Caiding Xu

Publikováno v: Tetrahedron Letters. 43:5673-5676

Treatment of (Z)-5-alkyl-2-en-4-ynoic acids ( 1 ), prepared by the Pd-catalyzed alkynylzinc–β-haloacrylic acid coupling, with 5–10 mol% of ZnBr2 can produce 6-alkyl-2H-pyran-2-ones ( 2 ) along with minor amounts of (Z)-5-alkylidenefuran-2(5H)-on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65dc54af3cf6e8f83364648309da184
https://doi.org/10.1016/s0040-4039(02)01128-0

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Intermolecular trapping of acylpalladium and related acylmetal derivatives with active C–H compounds

Autor: Izumi Shimoyama, Caiding Xu, Ei-ichi Negishi, Hidefumi Makabe, Show-Yee Liou

Publikováno v: Journal of Molecular Catalysis A: Chemical. 143:279-286

The reaction of aryl and alkenyl iodides and bromides with highly acidic ketones in the presence of CO (40–45 atm), NEt3 (1–2 equiv.), and 5 mol% of Cl2Pd(PPh3)2 in DMF at 100°C provides the corresponding enol carboxylates formed via trapping of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d267ff03750cb855ca5d057e7ef2f3e7
https://doi.org/10.1016/s1381-1169(98)00395-1

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A highly efficient and selective synthesis of lissoclinolide featuring hydrogen transfer hydrozirconation,trans-selective Pd-catalyzed cross coupling of alkenylzirconiums with 1,1-dibromoalkenes and Ag-catalyzed lactonization providing(Z)-γ-alkylidenebutenolides

Autor: Caiding Xu, Ei-ichi Negishi

Publikováno v: Tetrahedron Letters. 40:431-434

An antibiotic lissoclinolide has been synthesized from propargyl alcohol in 9 steps and in 32% overall yield via (i) hydrogen transfer hydrozirconation of TBS-protected propargyl alcohol with i -BuZrCp 2 Cl, (ii) Pd-catalyzed trans -selective cross c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::121dfd9a6a0a05a32cb88a12c3d798a6
https://doi.org/10.1016/s0040-4039(98)02394-6

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A New Synthesis of Allyl Ethers Via Allyldialkyltelluronium Salts

Autor: Shoumao Lu, Xian Huang, Caiding Xu

Publikováno v: Synthetic Communications. 23:2527-2531

Allyldialkyltelluronium bromides were treated with phenols in the presence of NaOH at room temperature, readily giving allyl aromatic ethers in excellent yields. This procedure represents an effici...

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https://doi.org/10.1080/00397919308012585

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ChemInform Abstract: The Reaction of Allyldialkyltelluronium Bromides with Anilines

Autor: Shoumao Lu, Xian Huang, Caiding Xu

Publikováno v: ChemInform. 26

Allyldialkyltelluronium bromides were treated with aromatic amines in 1,2-dichloroethane, readily giving allyl aryl amines in excellent yields.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1cd97dce3f6a071da220ee75cdaa65d
https://doi.org/10.1002/chin.199510101

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ChemInform Abstract: A Highly Efficient and Selective Synthesis of Lissoclinolide Featuring Hydrogen Transfer Hydrozirconation, trans-Selective Pd-Catalyzed Cross Coupling of Alkenylzirconiums with 1,1-Dibromoalkenes and Ag-Catalyzed Lactonization Providi

Autor: Caiding Xu, Ei-ichi Negishi

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::229155e9c066424416e7effb84d6bfee
https://doi.org/10.1002/chin.199917270

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ChemInform Abstract: Catalytic and Selective Conversion of (Z)-2-En-4-ynoic Acids to Either 2H-Pyran-2-ones in the Presence of ZnBr2 or (Z)-5-Alkylidenefuran-2(5H)-ones in the Presence of Ag2CO3

Autor: Ei-ichi Negishi, Luigi Anastasia, Caiding Xu

Publikováno v: ChemInform. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a9f189fbc4ffdb47ebb8a61a09b8e79
https://doi.org/10.1002/chin.200244150

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