Bifunctional small molecules that mediate the degradation of extracellular proteins.

Autor: Caianiello DF; Department of Chemistry, Yale University, New Haven, CT, USA., Zhang M; Department of Chemistry, Yale University, New Haven, CT, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Ray JD; Department of Chemistry, Yale University, New Haven, CT, USA., Howell RA; Department of Chemistry, Yale University, New Haven, CT, USA., Swartzel JC; Department of Chemistry, Yale University, New Haven, CT, USA.; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA., Branham EMJ; Department of Chemistry, Yale University, New Haven, CT, USA., Chirkin E; Department of Chemistry, Yale University, New Haven, CT, USA., Sabbasani VR; Department of Chemistry, Yale University, New Haven, CT, USA., Gong AZ; Department of Chemistry, Yale University, New Haven, CT, USA., McDonald DM; Department of Chemistry, Yale University, New Haven, CT, USA., Muthusamy V; Yale Center for Precision Cancer Modeling, Yale University School of Medicine, New Haven, CT, USA., Spiegel DA; Department of Chemistry, Yale University, New Haven, CT, USA. david.spiegel@yale.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2021 Sep; Vol. 17 (9), pp. 947-953. Date of Electronic Publication: 2021 Aug 19.

Exploiting E3 ubiquitin ligases to reeducate the tumor microenvironment for cancer therapy.

Autor: Li, Xian-Miao¹ (AUTHOR), Zhao, Zhen-Yu¹ (AUTHOR), Yu, Xiao¹ (AUTHOR), Xia, Qi-Dong¹ (AUTHOR), Zhou, Peng¹ (AUTHOR), Wang, Shao-Gang¹ (AUTHOR), Wu, Huan-Lei² (AUTHOR) wuhuanlei926@163.com, Hu, Jia¹ (AUTHOR) jiahu@tjh.tjmu.edu.cn

Publikováno v: Experimental Hematology & Oncology. 3/30/2023, Vol. 12 Issue 1, p1-19. 19p.

Targeted protein degradation combined with PET imaging reveals the role of host PD-L1 in determining anti-PD-1 therapy efficacy.

Autor: Du J; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China., Han S; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China., Zhou H; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China., Wang J; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China., Wang F; Department of Nuclear Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Peking University Cancer Hospital and Institute, Beijing, 100142, China., Zhao M; Department of Nuclear Medicine, Peking University Third Hospital, Beijing, 100191, China., Song R; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China., Li K; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China., Zhu H; Department of Nuclear Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Peking University Cancer Hospital and Institute, Beijing, 100142, China., Zhang W; Department of Nuclear Medicine, Peking University Third Hospital, Beijing, 100191, China. tsy1997@126.com., Yang Z; Department of Nuclear Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Peking University Cancer Hospital and Institute, Beijing, 100142, China. pekyz@163.com., Liu Z; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. liuzf@bjmu.edu.cn.; Department of Nuclear Medicine, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals, Peking University Cancer Hospital and Institute, Beijing, 100142, China. liuzf@bjmu.edu.cn.; Department of Nuclear Medicine, Peking University Third Hospital, Beijing, 100191, China. liuzf@bjmu.edu.cn.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China. liuzf@bjmu.edu.cn.; Peking University-Yunnan Baiyao International Medical Research Center, Beijing, 100191, China. liuzf@bjmu.edu.cn.

Publikováno v: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2024 Oct; Vol. 51 (12), pp. 3559-3571. Date of Electronic Publication: 2024 Jun 24.

Emerging Pharmacotherapeutic Strategies to Overcome Undruggable Proteins in Cancer.

Autor: Yuqing Lu, Yuewen Yang, Guanghao Zhu, Hairong Zeng, Yiming Fan, Fujia Guo, Dongshu Xu, Boya Wang, Dapeng Chen, Guangbo Ge

Publikováno v: International Journal of Biological Sciences; 2023, Vol. 19 Issue 11, p3360-3382, 23p

Crystal Structure Analysis of Two 4-Nitro-N-methylaniline Derivatives.

Autor: Goettler, Patricia E., Hamaker, Christopher G.

Publikováno v: Journal of Chemical Crystallography; Jun2022, Vol. 52 Issue 2, p251-259, 9p