Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Cai-ping Chen"'
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-13 (2024)
Abstract Tetrandrine (Tet), a well-known drug of calcium channel blocker, has been broadly applied for anti-inflammatory and anti-fibrogenetic therapy. However, due to the functional diversity of ubiquitous calcium channels, potential side-effects ma
Externí odkaz:
https://doaj.org/article/ca56769da1064f8bb53042f57f50d873
Autor:
Wei Zhao, Jie Sun, Liang-Yu Yao, Dong Hang, Ye-Qiong Li, Cai-Ping Chen, Yu-Wei Zhou, Xin Chen, Tao Tao, Li-Sha Wei, Yan-Yan Zheng, Xie Ge, Chao-Jun Li, Zhong-Cheng Xin, Yang Pan, Xin-Zhu Wang, Wei-Qi He, Xue-Na Zhang, Bing Yao, Min-Sheng Zhu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Reduced expression of myosin phosphatase target subunit 1 (MYPT1) is critical for the development of vasculogenic erectile dysfunction and a natural compound, lotusine, is found to increase MYPT1 expression and rescue penile smooth muscle function.
Externí odkaz:
https://doaj.org/article/42530947521a4ff28e376521282ac30a
Autor:
Qian-Ya Fan, Xiao-Dong Zhang, Ze-Di Hu, Shi-Shi Huang, Shi-Guo Zhu, Cai-Ping Chen, Xiong Zhang, Jian-Yong Wang
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
IntroductionBlepharospasm is uncommon in Parkinson's disease, especially in the peak-dose dyskinesia period.Case presentationWe herein present the case of a patient with PD who developed blepharospasm in the peak-dose dyskinesia period. The symptom w
Externí odkaz:
https://doaj.org/article/23305deb8047432195a22e5cc1024a97
Autor:
Cai-Ping Chen, Xiang Lu
Publikováno v:
Journal of International Medical Research, Vol 50 (2022)
Background Gonadotropin-releasing hormone receptor (GnRHR) is expressed in several malignant tumors and inhibits the proliferation and metastasis of cancer cells, but its role in triple-negative breast cancers (TNBCs) is unclear. This study investiga
Externí odkaz:
https://doaj.org/article/64b81c265ef74802bfbf2ce2905be166
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 937-951 (2019)
Artemisinin and its derivatives (ARTs) were reported to display heme-dependent antitumor activity. On the other hand, histone deacetylase inhibitors (HDACi) were known to be able to promote heme synthesis in erythroid cells. Nevertheless, the effect
Externí odkaz:
https://doaj.org/article/1ed746682aee46ffaa8f6ac1bb4579aa
Autor:
Cheng-Hai Zhang, Pei Wang, Dong-Hai Liu, Cai-Ping Chen, Wei Zhao, Xin Chen, Chen Chen, Wei-Qi He, Yan-Ning Qiao, Tao Tao, Jie Sun, Ya-Jing Peng, Ping Lu, Kaizhi Zheng, Siobhan M. Craige, Lawrence M. Lifshitz, John F. Keaney Jr, Kevin E. Fogarty, Ronghua ZhuGe, Min-Sheng Zhu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The molecular basis of the basal tone generated by internal anal sphincters (IAS) is largely unknown. Here, the authors show that the tone arises from a global rise in intracellular Ca2+ in smooth muscle cells via a Ryanodine receptor-TMEM16A-L-type
Externí odkaz:
https://doaj.org/article/b4b7ab0c59cd416bb5911aec0550d29f
Autor:
Yu-Wei Zhou, Jie Sun, Ye Wang, Cai-Ping Chen, Tao Tao, Ming Ma, Xin Chen, Xue-Na Zhang, Li-Yuan Yang, Zhong-Liang Zhang, Ye-Qiong Li, Zhi-Hui Jiang, Tian-Tian Qiu, Han Wang, Yang Pan, Jian Zhang, Hua-Qun Chen, Pei Wang, Min-Sheng Zhu
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying the agonistic relaxation of airway smooth muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f884b97fb4bfad5d7d6f709bf71daa09
https://doi.org/10.1073/pnas.2121513119
https://doi.org/10.1073/pnas.2121513119
Autor:
Peng Li, Tong Jin, Qing-Qiong Deng, Ning Chen, Hao-Ran Zhang, Wu-Xia Zhang, Yi-Jie Li, Zi-Yu Meng, Lin Xing, Yuan-Yuan Zhang, Ling-Min Zhan, Cai-Ping Cheng, Jin-Zhong Zhao, Bang-Ze Fu, Tian-Gang Li, Peng Lu
Publikováno v:
World Journal of Traditional Chinese Medicine, Vol 10, Iss 3, Pp 383-398 (2024)
Objective: Illumination of the integrative effects of herbs in a formula is a bottleneck that limits the development of traditional Chinese medicine (TCM). In the present study, we developed a transcriptome-based multi-scale network pharmacology mode
Externí odkaz:
https://doaj.org/article/1b1a35bb4a6348ec9be7075beca0f8c3
Autor:
Jian Sun, Xiao-Ping Liao, Cai-Ping Chen, Ya-Hong Liu, Teng-Fei Long, Bing He, Hao Ren, Xu Kuang, Jin-Ru Yan, Yu-Zhang He
Publikováno v:
Antimicrobial Agents and Chemotherapy. 65
The global spread of antimicrobial-resistant bacteria has been one of the most severe threats to public health. The emergence of the mcr-1 gene has posed a considerable threat to antimicrobial medication since it deactivates one last-resort antibioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91cf8d6e87b48a3f96ebb083c9074d0d
https://doi.org/10.1128/aac.01054-21
https://doi.org/10.1128/aac.01054-21
Autor:
Yu-Zhang, He, Jin-Ru, Yan, Bing, He, Hao, Ren, Xu, Kuang, Teng-Fei, Long, Cai-Ping, Chen, Xiao-Ping, Liao, Ya-Hong, Liu, Jian, Sun
Publikováno v:
Antimicrobial Agents and Chemotherapy
The global spread of antimicrobial-resistant bacteria has been one of the most severe threats to public health. The emergence of the mcr-1 gene has posed a considerable threat to antimicrobial medication since it deactivates one last-resort antibioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da087901965d41e72faefc51f95b5094
https://pubmed.ncbi.nlm.nih.gov/34339270
https://pubmed.ncbi.nlm.nih.gov/34339270