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Akademický článek

Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy

Autor: Cai-Yu Lian, Bing-Xin Chu, Wei-Hao Xia, Zhen-Yong Wang, Rui-Feng Fan, Lin Wang

Publikováno v: Journal of Advanced Research, Vol 46, Iss , Pp 87-100 (2023)

Introduction: Lead (Pb) is an environmental toxicant that poses severe health risks to humans and animals, especially renal disorders. Pb-induced nephrotoxicity has been attributed to oxidative stress, in which apoptosis and autophagy are core events

Externí odkaz: https://doaj.org/article/ec3b83e02a954c9db00d41f1e6453cba

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Enhanced Extracellular Matrix Degradation in Growth Plate Contributes to Manganese Deficiency-Induced Tibial Dyschondroplasia in Broiler Chicks

Autor: Lin Wang, Zhen-Yong Wang, Cai-Yu Lian, Cong Jin, Peng-Fei Dong

Publikováno v: Biological Trace Element Research. 200:3326-3335

Manganese (Mn) is a crucial trace element for poultry nutrition, and its deficiency compromises tibial cartilage development, leading to perosis and a higher incidence of slipped tendon. Tibial dyschondroplasia (TD) is a metabolic cartilage disease c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c86c4dfa5c7a285b4d3a8a31b38774
https://doi.org/10.1007/s12011-021-02921-w

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Trehalose prevents glyphosate-induced hepatic steatosis in roosters by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation

Autor: Cai-Yu Lian, Run-Zhou Wang, Jie Wang, Zhen-Yong Wang, Wei Zhang, Lin Wang

Publikováno v: Veterinary research communications.

Glyphosate (Gly) is a globally spread herbicide that can cause toxic injuries to hepatocytes. Dietary trehalose (Tre) exerts cytoprotective effect in numerous liver diseases through anti-oxidant and anti-inflammatory properties. However, it is yet to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905b7e343b1672a9c79f4fc561bce4d3
https://pubmed.ncbi.nlm.nih.gov/36261742

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Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy

Autor: Cai-Yu Lian, Bing-Xin Chu, Wei-Hao Xia, Zhen-Yong Wang, Rui-Feng Fan, Lin Wang

Publikováno v: J Adv Res

INTRODUCTION: Lead (Pb) is an environmental toxicant that poses severe health risks to humans and animals, especially renal disorders. Pb-induced nephrotoxicity has been attributed to oxidative stress, in which apoptosis and autophagy are core events

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e486e2d52a48c77b78871d9d87942fc
https://europepmc.org/articles/PMC10105071/

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Akademický článek

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Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig cells

Autor: Lu, Lu, Jing-Bo, Liu, Jin-Qiu, Wang, Cai-Yu, Lian, Zhen-Yong, Wang, Lin, Wang

Publikováno v: Environmental Pollution. 314:120314

Glyphosate (GLY), one of the most extensively used herbicides in the world, has been shown to inhibit testosterone synthesis in male animals. Mitochondria are crucial organelles for testosterone synthesis and its dysfunction has been demonstrated to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d122ad2cd0bab97cda2804b4307f0d
https://doi.org/10.1016/j.envpol.2022.120314

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mTORC1 activation contributes to autophagy inhibition via its recruitment to lysosomes and consequent lysosomal dysfunction in cadmium-exposed rat proximal tubular cells

Autor: Cai-Yu Lian, Zi-Fa Li, Dian-Gang Han, Heng Yang, Lin Wang, Zhen-Zhen Zhai

Publikováno v: Journal of inorganic biochemistry. 212

Autophagy dysregulation is implicated in cadmium (Cd)-induced nephrotoxicity. The mammalian target of rapamycin complex 1 (mTORC1) is a negative regulator of autophagy, but its role in Cd-induced autophagy inhibition and possible regulatory mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591559ca7562d1dfe610eb0b67d0c565
https://pubmed.ncbi.nlm.nih.gov/32862047

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