Výsledky vyhledávání

Nitration and Inactivation of IDO by Peroxynitrite

Autor: Felix Lin, Suwako Fujigaki, Osamu Takikawa, Junichi Masuda, Kanako Takahashi, Cai Y. Chen, Mitsuru Seishima, Hidetsugu Fujigaki, Brian M. Martin, Kuniaki Saito, Jeffrey A. Kowalak, Sanford P. Markey

Publikováno v: The Journal of Immunology. 176:372-379

IDO induction can deplete l-tryptophan in target cells, an effect partially responsible for the antimicrobial activities and antiallogeneic T cell responses of IFN-γ in human macrophages, dendritic cells, and bone marrow cells. l-Tryptophan depletio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d59b9359c61926b4b99003c0b22425
https://doi.org/10.4049/jimmunol.176.1.372

Zobrazit plný text záznamu

Metabolism of l-Tryptophan to Kynurenate and Quinolinate in the Central Nervous System: Effects of 6-Chlorotryptophan and 4-Chloro-3-Hydroxyanthranilate

Autor: Kuniaki Saito, S. P. Markey, Cai Y. Chen, Melvyn P. Heyes, Dmitry B. Naritsin

Publikováno v: Journal of Neurochemistry. 65:2217-2226

The metabolism of L-tryptophan to the neuro-active kynurenine pathway metabolites, L-kynurenine, kynurenate and quinolinate, and the effects of two inhibitors of quinolinate synthesis (6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate) were inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a14111cf0fbf73bf36365c8d1e83ebb
https://doi.org/10.1046/j.1471-4159.1995.65052217.x

Zobrazit plný text záznamu

Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types

Autor: Melvyn P. Heyes, Cai Y. Chen, Kuniaki Saito, Eugene O. Major

Publikováno v: Biochemical Journal. 326:351-356

Substantial increases in the tryptophan–kynurenine pathway metabolites, L-kynurenine and the neurotoxin quinolinic acid, occur in human brain, blood and systemic tissues during immune activation. Studies in vitrohave shown that not all human cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45b1e96dba3ea327cd9f6c167e7142b
https://doi.org/10.1042/bj3260351

Zobrazit plný text záznamu

Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation

Autor: Melvyn P. Heyes, Ju Li, Margit G. Proescholdt, Sanford P. Markey, Cai Y. Chen, Kensuke Kawai, Martin A. Proescholdt, Mark Zito, Thaddeus S. Nowak, Kuniaki Saito, Karen E. Beagles

Publikováno v: Journal of neurochemistry. 69(4)

Quinolinic acid is an excitotoxic kynurenine pathway metabolite, the concentration of which increases in human brain during immune activation. The present study compared quinolinate responses to systemic and brain immune activation in gerbils and rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd4b39e57ac53f5d632be8278f0b41d
https://pubmed.ncbi.nlm.nih.gov/9326281

Zobrazit plný text záznamu

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells)

Autor: M Masana, Kuniaki Saito, Jeffrey S. Crowley, Melvyn P. Heyes, Cai Y. Chen, Sanford P. Markey

Publikováno v: The Biochemical journal. 291

Accumulation of quinolinic acid and L-kynurenine occurs in the brain and/or blood following immune activation, and may derive from L-tryptophan following induction of indoleamine 2,3-dioxygenase and other kynurenine-pathway enzymes. In the present st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d939c3f7ecbcfc718f108c0728a0c459
https://pubmed.ncbi.nlm.nih.gov/8471029

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání