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Akademický článek

The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis In Vitro and Induces Vasodilatation Without Desensitisation In Vivo

Autor: Cai Read, Duuamene Nyimanu, Peiran Yang, Rhoda E. Kuc, Thomas L. Williams, Christopher M. Fitzpatrick, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport

Publikováno v: Frontiers in Pharmacology, Vol 11 (2021)

Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial hypertension but are not suitab

Externí odkaz: https://doaj.org/article/2d0660c081eb47399d2ca55e2ed4196f

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Akademický článek

Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR1), not G‐Protein‐Coupled Receptor 1 (GPR1), in Human and Rat Vasculature

Autor: Amanda J. Kennedy, Peiran Yang, Cai Read, Rhoda E. Kuc, Lucy Yang, Emily J. A. Taylor, Colin W. Taylor, Janet J. Maguire, Anthony P. Davenport

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 10 (2016)

BackgroundCirculating levels of chemerin are significantly higher in hypertensive patients and positively correlate with blood pressure. Chemerin activates chemokine‐like receptor 1 (CMKLR1 or ChemR23) and is proposed to activate the “orphan” G

Externí odkaz: https://doaj.org/article/514a9408dd984b9285682713b98ed396

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G protein signaling–biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists

Autor: Nicole M. Kennedy, Cullen L. Schmid, Agnes Acevedo-Canabal, Edward L. Stahl, Laura M. Bohn, Cai Read, Travis W. Grim, Thomas D. Bannister

Publikováno v: Proc Natl Acad Sci U S A

The ability of a ligand to preferentially promote engagement of one signaling pathway over another downstream of GPCR activation has been referred to as signaling bias, functional selectivity, and biased agonism. The presentation of ligand bias refle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c3fb22b788a2b9c93de2a22ba74551
https://doi.org/10.1073/pnas.2102178118

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International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand

Autor: Thomas L Williams, David J. Huggins, Petra Sulentic, Janet J. Maguire, Robyn Macrae, Cai Read, Duuamene Nyimanu, Peiran Yang, Robert C. Glen, Anthony P. Davenport

Publikováno v: Pharmacological Reviews

The predicted protein encoded by the APJ gene discovered in 1993 was originally classified as a class A G protein-coupled orphan receptor but was subsequently paired with a novel peptide ligand, apelin-36 in 1998. Substantial research identified a fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e33aeb1af100558c125fd20a12e23d6
http://europepmc.org/articles/PMC6731456

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A novel cyclic biased agonist of the apelin receptor, MM07, is disease modifying in the rat monocrotaline model of pulmonary arterial hypertension

Autor: Robert C. Glen, Anthony P. Davenport, Duuamene Nyimanu, Alexi Crosby, Janet J. Maguire, Guido Buonincontri, Cai Read, Mark Southwood, Thomas L Williams, Nicholas W. Morrell, Peiran Yang, Rhoda E. Kuc, Stephen J. Sawiak

Publikováno v: British Journal of Pharmacology

© 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. Background and Purpose: Apelin is an endogenous vasodilatory and inotropic peptide that is down-regulated in human p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546664dd224b2e81d071db457495fa1a
http://europepmc.org/articles/PMC6468262

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The G Protein Biased Small Molecule Apelin Agonist CMF-019 is Disease Modifying in Endothelial Cell Apoptosis

Autor: Cai, Read, Duuamene, Nyimanu, Peiran, Yang, Rhoda E, Kuc, Thomas L, Williams, Christopher M, Fitzpatrick, Richard, Foster, Robert C, Glen, Janet J, Maguire, Anthony P, Davenport

Publikováno v: Frontiers in Pharmacology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a601ad08053ad6f105fd2efee8281052
https://pubmed.ncbi.nlm.nih.gov/33716722

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Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo

Autor: Rhoda E. Kuc, Robert C. Glen, Anthony P. Davenport, Thomas L Williams, Peiran Yang, Janet J. Maguire, Andrew Smart, Duuamene Nyimanu, Cai Read, Lucy J. Holt, Haren Arulanantham

The apelin receptor is a potential target in the treatment of heart failure and pulmonary arterial hypertension where levels of endogenous apelin peptides are reduced but significant receptor levels remain. Our aim was to characterise the pharmacolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae3b8d28cc2ad933db5bb33d968d90b
https://www.repository.cam.ac.uk/handle/1810/290748

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Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension

Autor: Benjamin E, Garfield, Alexi, Crosby, Dongmin, Shao, Peiran, Yang, Cai, Read, Steven, Sawiak, Stephen, Moore, Lisa, Parfitt, Carl, Harries, Martin, Rice, Richard, Paul, Mark L, Ormiston, Nicholas W, Morrell, Michael I, Polkey, Stephen John, Wort, Paul R, Kemp

Publikováno v: Thorax. 74(2)

Skeletal muscle dysfunction is a clinically important complication of pulmonary arterial hypertension (PAH). Growth/differentiation factor 15 (GDF-15), a prognostic marker in PAH, has been associated with muscle loss in other conditions. We aimed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99568eb8a9b4d1131943a42a1f49529b
https://pubmed.ncbi.nlm.nih.gov/30554140

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Abstract P183: Chemokine-like Receptor 1 Mediates the Vasoconstrictor Actions of Chemerin in vitro and in vivo

Autor: Amanda J. Kennedy, Cai Read, Rhoda E. Kuc, Peiran Yang, Janet J. Maguire, Anthony P. Davenport

Publikováno v: Hypertension. 68

Hypertensive patients have significantly higher plasma concentrations of the adipokine chemerin compared with healthy controls, and levels of chemerin positively correlate with systolic and diastolic blood pressure. Chemerin activates chemokine-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68af986b678c54edb07671d4e275ec14
https://doi.org/10.1161/hyp.68.suppl_1.p183

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