YAP K236 acetylation facilitates its nucleic export and deprived the protection against cardiac hypertrophy in mice

Autor: Wang, Panxia ^{a, 1}, Wang, Luping ^{a, 1}, Liu, Cui ^{b, 1}, Hu, Yuehuai ^b, Feng, Guodong ^b, Lian, Zuqian ^a, Lu, Jing ^b, He, Ping ^c, Cai, Hexin ^a, Liang, Xiaohui ^d, Liu, Peiqing ^{e, f, ⁎}, Wu, Xiaoqian ^{a, ⁎⁎}

Publikováno v: In Pharmacological Research January 2025 211

YAP K236 acetylation facilitates its nucleic export and deprived the protection against cardiac hypertrophy in mice.

Autor: Wang P; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, PR China., Wang L; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, PR China., Liu C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China., Hu Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China., Feng G; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China., Lian Z; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, PR China., Lu J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China., He P; Department of Pharmacy, The Eighth Affiliated Hospital, Sun Yat-sen University, Shennan Rord 3025, Shenzhen 518033, PR China., Cai H; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, PR China., Liang X; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 511436, PR China., Liu P; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou 510006, PR China; Guangdong Provincial Engineering Laboratory of Druggability and New Drugs Evaluation, Guangzhou 510006, PR China. Electronic address: liupq@mail.sysu.edu.cn., Wu X; Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, PR China. Electronic address: wuxiaoqian@gzhmu.edu.cn.

Publikováno v: Pharmacological research [Pharmacol Res] 2024 Dec 31; Vol. 211, pp. 107573. Date of Electronic Publication: 2024 Dec 31.