Zobrazeno 1 - 10
of 324
pro vyhledávání: '"Cahalan MD"'
Autor:
Donglt, TX, Othylt, S, Greenberg, ML, Jairaman, A, Akunwafo, C, Leverrier, S, Yu, Y, Parkerl, I, Dynes, JL, Cahalan, MD
Publikováno v:
Donglt, TX; Othylt, S; Greenberg, ML; Jairaman, A; Akunwafo, C; Leverrier, S; et al.(2017). Intermittent Ca2+ signals mediated by Orail regulate basal T cell motility. ELIFE, 6. doi: 10.7554/eLife.27827. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1rr251qn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::7c61230b91ae6cc106ec1b4749cacdfb
http://www.escholarship.org/uc/item/1rr251qn
http://www.escholarship.org/uc/item/1rr251qn
Publikováno v:
Newton, RH; Leverrier, S; Srikanth, S; Gwack, Y; Cahalan, MD; & Walsh, CM. (2011). Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+influx and mitochondrial reactive oxygen generation. Journal of Immunology, 186(2), 940-950. doi: 10.4049/jimmunol.1000942. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/42q5j519
DRAK2 is a serine/threonine kinase highly enriched in lymphocytes that raises the threshold for T cell activation and maintains T cell survival following productive activation. T cells lacking DRAK2 are prone to activation under suboptimal conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::9b395fcbac8358e939a31edbe85018f9
http://www.escholarship.org/uc/item/42q5j519
http://www.escholarship.org/uc/item/42q5j519
Publikováno v:
Miller, MJ; Safrina, O; Parker, I; & Cahalan, MD. (2004). Imaging the single cell dynamics of CD4+T cell activation by dendritic cells in lymph nodes. Journal of Experimental Medicine, 200(7), 847-856. doi: 10.1084/jem.20041236. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/10s4s93c
The adaptive immune response is initiated in secondary lymphoid organs by contact between antigen-bearing dendritic cells (DCs) and antigen-specific CD4+T cells. However, there is scant information regarding the single cell dynamics of this process i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::83b1038d84af07329db57972781ff53e
http://www.escholarship.org/uc/item/10s4s93c
http://www.escholarship.org/uc/item/10s4s93c
Publikováno v:
Ashot Kozak, J; Kerschbaum, HH; & Cahalan, MD. (2002). Distinct properties of CRAC and MIC channels in RBL cells. Journal of General Physiology, 120(2), 221-235. doi: 10.1085/jgp.20028601. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2qh5f5bm
In rat basophilic leukemia (RBL) cells and Jurkat T cells, Ca2+release-activated Ca2+(CRAC) channels open in response to passive Ca2+store depletion. Inwardly rectifying CRAC channels admit monovalent cations when external divalent ions are removed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::0fe8f88fbb13b94a8eb3623cf08103e8
http://www.escholarship.org/uc/item/2qh5f5bm
http://www.escholarship.org/uc/item/2qh5f5bm
Publikováno v:
Wei, X; Si, MS; Imagawa, DK; Ji, P; Tromberg, BJ; & Cahalan, MD. (2000). Perillyl alcohol inhibits TCR-mediated [Ca2+](i) signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes. Cellular Immunology, 201(1), 6-13. doi: 10.1006/cimm.2000.1637. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/51p3m6v5
Perillyl alcohol (POH) inhibits isoprenylation and has shown anticancer and chemopreventive properties in rodent models. The mechanism that underlies the anticancer activity of POH and other isoprenylation inhibitors is unknown but has been postulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::ce03abf2c1b50dd6f3d092280a8f04f3
http://www.escholarship.org/uc/item/51p3m6v5
http://www.escholarship.org/uc/item/51p3m6v5
Publikováno v:
Wei, XB; Krasieva, TB; Cahalan, MD; & Tromberg, BJ. (1999). Polarity and sensitivity of T lymphocyte studied by an optical trap. OPTICAL DIAGNOSTICS AND LIVING CELLS II, PROCEEDINGS OF, 3604, 13-17. doi: 10.1117/12.349197. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8kc798rs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::76784e92bff98a6f5be91c49cf993e8b
http://www.escholarship.org/uc/item/8kc798rs
http://www.escholarship.org/uc/item/8kc798rs
Publikováno v:
Wei, X; Krasieva, TB; Zhang, Z; Negulescu, PA; Sun, CH; Berns, MW; et al.(1998). Mapping the polarity and stimulus density requirements for T cell activation. Proceedings of SPIE-The International Society for Optical Engineering, 3548, 11-16. doi: 10.1117/12.317875. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3jg9z0h9
T-cell contact with antigen-presenting cells (APC) initiates an activation cascade which includes an increase in T-cell intracellular calcium ([Ca2+]iand leads to T-cell proliferation and differentiation. Although T-cell/APC physical contact is requi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::fccd71189fa61addbf39a1855da90775
http://www.escholarship.org/uc/item/3jg9z0h9
http://www.escholarship.org/uc/item/3jg9z0h9
Publikováno v:
Wei, X; Krasieva, TB; Zhang, Z; Negulescu, PA; Sun, CH; Cahalan, MD; et al.(1998). Mapping the polarity for T cell activation with an optical trap. Proceedings of SPIE-The International Society for Optical Engineering, 3260, 24-29. doi: 10.1117/12.307111. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3t28q61v
In the body, individual T helper lymphocytes need to be activated first by physical contact with antigen-presenting cells (APC). T-cell contact with APCs initiates an activation cascade which includes an increase in T-cell intracellular calcium and l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::f7e8774768c6988feaeaa395e5ddbe6e
http://www.escholarship.org/uc/item/3t28q61v
http://www.escholarship.org/uc/item/3t28q61v
Autor:
Wei, X, Krasieva, TB, Negulescu, PA, Sun, CH, Berns, MW, Sonek, GJ, Tromberg, BJ, Cahalan, MD
Publikováno v:
Wei, X; Krasieva, TB; Negulescu, PA; Sun, CH; Berns, MW; Sonek, GJ; et al.(1998). T cell activation studied by optical trap. BIOPHYSICAL JOURNAL, 74(2), A378-A378. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1z4323f1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::980bc1520f3e31c0f8bb80f5e17f365b
http://www.escholarship.org/uc/item/1z4323f1
http://www.escholarship.org/uc/item/1z4323f1
Autor:
Wei, X, Zhang, Z, Krasieva, TB, Negulescu, PA, Berns, MW, Cahalan, MD, Sonek, GJ, Tromberg, BJ
Publikováno v:
Wei, X; Zhang, Z; Krasieva, TB; Negulescu, PA; Berns, MW; Cahalan, MD; et al.(1997). Laser trapping microscopy as a diagnostic technique for the study of cellular resopnse and laser-cell interactions. Proceedings of SPIE-The International Society for Optical Engineering, 2983, 22-28. doi: 10.1117/12.274335. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1k0172t2
Optical laser trapping microscopy has emerged as a powerful tool not only for the optical manipulation of cells and macromolecules, but also for the study of cellular physiological responses via force transduction and fluorescence imaging. We describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::36d6601b596b5d5ec423ff47d293afa6
http://www.escholarship.org/uc/item/1k0172t2
http://www.escholarship.org/uc/item/1k0172t2