Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Cagla Eroglu"'
Autor:
Francesco Paolo Ulloa Severino, Oluwadamilola O. Lawal, Kristina Sakers, Shiyi Wang, Namsoo Kim, Alexander David Friedman, Sarah Anne Johnson, Chaichontat Sriworarat, Ryan H. Hughes, Scott H. Soderling, Il Hwan Kim, Henry H. Yin, Cagla Eroglu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Synaptogenesis is essential for circuit development; however, it is unknown whether it is critical for the establishment and performance of goal-directed voluntary behaviors. Here, we show that operant conditioning via lever-press for food r
Externí odkaz:
https://doaj.org/article/9364fb91fdb84768b77cbf35ca5208f4
Autor:
Xinhong Chen, Damien A. Wolfe, Dhanesh Sivadasan Bindu, Mengying Zhang, Naz Taskin, David Goertsen, Timothy F. Shay, Erin E. Sullivan, Sheng-Fu Huang, Sripriya Ravindra Kumar, Cynthia M. Arokiaraj, Viktor M. Plattner, Lillian J. Campos, John K. Mich, Deja Monet, Victoria Ngo, Xiaozhe Ding, Victoria Omstead, Natalie Weed, Yeme Bishaw, Bryan B. Gore, Ed S. Lein, Athena Akrami, Cory Miller, Boaz P. Levi, Annika Keller, Jonathan T. Ting, Andrew S. Fox, Cagla Eroglu, Viviana Gradinaru
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Delivering genes to and across the brain vasculature efficiently and specifically across species remains a critical challenge for addressing neurological diseases. We have evolved adeno-associated virus (AAV9) capsids into vectors that trans
Externí odkaz:
https://doaj.org/article/7b4783a47cea47ffabf5e460813881df
Autor:
Takumi Taketomi, Takunori Yasuda, Rikuri Morita, Jaehyun Kim, Yasuteru Shigeta, Cagla Eroglu, Ryuhei Harada, Fuminori Tsuruta
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Hevin is a secreted extracellular matrix protein that is encoded by the SPARCL1 gene. Recent studies have shown that Hevin plays an important role in regulating synaptogenesis and synaptic plasticity. Mutations in the SPARCL1 gene increase t
Externí odkaz:
https://doaj.org/article/72a771fc41bc4413903860fc7e899dbb
Autor:
Gang Chen, Jing Xu, Hao Luo, Xin Luo, Sandeep K. Singh, Juan J. Ramirez, Michael L. James, Joseph P. Mathew, Miles Berger, Cagla Eroglu, Ru-Rong Ji
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted protein that regulates synapse formation in the brain. Here we show that astrocytic hevin signaling plays a critical role in maintaining chronic pain. Compared with
Externí odkaz:
https://doaj.org/article/1cad786a1fe5456cb44ae143f945228a
Autor:
Caley J. Burrus, Spencer U. McKinstry, Namsoo Kim, M. Ilcim Ozlu, Aditya V. Santoki, Francia Y. Fang, Annie Ma, Yonca B. Karadeniz, Atesh K. Worthington, Ioannis Dragatsis, Scott Zeitlin, Henry H. Yin, Cagla Eroglu
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 642-657.e6 (2020)
Summary: Huntington’s disease (HD) is caused by an autosomal dominant polyglutamine expansion mutation of Huntingtin (HTT). HD patients suffer from progressive motor, cognitive, and psychiatric impairments, along with significant degeneration of th
Externí odkaz:
https://doaj.org/article/6f46fe39fbe14269bc81dcb22d7ced0a
Autor:
Rocio Gomez-Pastor, Eileen T. Burchfiel, Daniel W. Neef, Alex M. Jaeger, Elisa Cabiscol, Spencer U. McKinstry, Argenia Doss, Alejandro Aballay, Donald C. Lo, Sergey S. Akimov, Christopher A. Ross, Cagla Eroglu, Dennis J. Thiele
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevat
Externí odkaz:
https://doaj.org/article/10e213fe581949ff9cd3a516b23f2861
Autor:
W Christopher Risher, Sagar Patel, Il Hwan Kim, Akiyoshi Uezu, Srishti Bhagat, Daniel K Wilton, Louis-Jan Pilaz, Jonnathan Singh Alvarado, Osman Y Calhan, Debra L Silver, Beth Stevens, Nicole Calakos, Scott H Soderling, Cagla Eroglu
Publikováno v:
eLife, Vol 3 (2014)
During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this competitive environment is un
Externí odkaz:
https://doaj.org/article/b90e1976a60c4962957813477cb052d4
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107591 (2014)
Dendritic spines are the primary recipients of excitatory synaptic input in the brain. Spine morphology provides important information on the functional state of ongoing synaptic transmission. One of the most commonly used methods to visualize spines
Externí odkaz:
https://doaj.org/article/39796483ed464e4e9fcec29223bf9422
Autor:
Shiyi Wang, Dhanesh Sivadasan Bindu, Christabel Xin Tan, Kristina Sakers, Tetsuya Takano, Maria Pia Rodriguez, Kylie Dimond, Scott H. Soderling, Albert R. La Spada, Cagla Eroglu
Astrocytes tightly control neuronal connectivity and function in the brain through direct contact with synapses1–5. These glial cells become reactive during disease pathogenesis6–8including Parkinson’s disease (PD)9–14. However, it remains un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d0d24a6969c12faebbdafe4e2a57deb
https://doi.org/10.1101/2023.04.09.536178
https://doi.org/10.1101/2023.04.09.536178
Autor:
Dolores Irala, Shiyi Wang, Kristina Sakers, Leykashree Nagendren, Francesco Paolo Ulloa-Severino, Dhanesh Sivadasan Bindu, Cagla Eroglu
Publikováno v:
bioRxiv
SUMMARYAstrocytes strongly promote the formation and maturation of synapses by secreted proteins. To date, several astrocyte-secreted synaptogenic proteins controlling different stages of excitatory synapse development have been identified. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369b09c7883c317c5c861a5f3d7486e7
https://europepmc.org/articles/PMC10104008/
https://europepmc.org/articles/PMC10104008/