Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Caghan, Kizil"'
Autor:
Andrea Pedroni, Elanur Yilmaz, Lisa Del Vecchio, Prabesh Bhattarai, Inés Talaya Vidal, Yu-Wen E. Dai, Konstantinos Koutsogiannis, Caghan Kizil, Konstantinos Ampatzis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The proper functioning of the heart relies on the intricate interplay between the central nervous system and the local neuronal networks within the heart itself. While the central innervation of the heart has been extensively studied, the or
Externí odkaz:
https://doaj.org/article/750848b33cba4784b060844c4693a8d8
Autor:
Özkan İş, Xue Wang, Joseph S. Reddy, Yuhao Min, Elanur Yilmaz, Prabesh Bhattarai, Tulsi Patel, Jeremiah Bergman, Zachary Quicksall, Michael G. Heckman, Frederick Q. Tutor-New, Birsen Can Demirdogen, Launia White, Shunsuke Koga, Vincent Krause, Yasuteru Inoue, Takahisa Kanekiyo, Mehmet Ilyas Cosacak, Nastasia Nelson, Annie J. Lee, Badri Vardarajan, Richard Mayeux, Naomi Kouri, Kaancan Deniz, Troy Carnwath, Stephanie R. Oatman, Laura J. Lewis-Tuffin, Thuy Nguyen, for the Alzheimer’s Disease Neuroimaging Initiative, Minerva M. Carrasquillo, Jonathan Graff-Radford, Ronald C. Petersen, Clifford R. Jr Jack, Kejal Kantarci, Melissa E. Murray, Kwangsik Nho, Andrew J. Saykin, Dennis W. Dickson, Caghan Kizil, Mariet Allen, Nilüfer Ertekin-Taner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s disease and control brains and focused on vascular and astrocyte clusters as mai
Externí odkaz:
https://doaj.org/article/0f4d86fabcd9496f8761615d7234bc5b
Autor:
Tohid Siddiqui, Mehmet Ilyas Cosacak, Stanislava Popova, Prabesh Bhattarai, Elanur Yilmaz, Annie J. Lee, Yuhao Min, Xue Wang, Mariet Allen, Özkan İş, Zeynep Tansu Atasavum, Natalia Rodriguez-Muela, Badri N. Vardarajan, Delaney Flaherty, Andrew F. Teich, Ismael Santa-Maria, Uwe Freudenberg, Carsten Werner, Giuseppe Tosto, Richard Mayeux, Nilüfer Ertekin-Taner, Caghan Kizil
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Neurogenesis, crucial for brain resilience, is reduced in Alzheimer’s disease (AD) that induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring neurogenesis could counteract neurodegenerative pathology.
Externí odkaz:
https://doaj.org/article/bebfc2431c024aae887659ececd580cc
Autor:
Dheeraj Rayamajhi, Mert Ege, Kirill Ukhanov, Christa Ringers, Yiliu Zhang, Inyoung Jung, Percival P D'Gama, Summer Shijia Li, Mehmet Ilyas Cosacak, Caghan Kizil, Hae-Chul Park, Emre Yaksi, Jeffrey R Martens, Steven L Brody, Nathalie Jurisch-Yaksi, Sudipto Roy
Publikováno v:
PLoS Biology, Vol 22, Iss 1, p e3002468 (2024)
In vertebrates, olfactory receptors localize on multiple cilia elaborated on dendritic knobs of olfactory sensory neurons (OSNs). Although olfactory cilia dysfunction can cause anosmia, how their differentiation is programmed at the transcriptional l
Externí odkaz:
https://doaj.org/article/0a623c9a10644aa5abfb23583ad6e4c7
Autor:
Fushun Chen, Melina Köhler, Gokhan Cucun, Masanari Takamiya, Caghan Kizil, Mehmet Ilyas Cosacak, Sepand Rastegar
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107342- (2023)
Summary: Sox transcription factors are crucial for vertebrate nervous system development. In zebrafish embryo, sox1 genes are expressed in neural progenitor cells and neurons of ventral spinal cord. Our recent study revealed that the loss of sox1a an
Externí odkaz:
https://doaj.org/article/c4bbec29a3b347e7a5bb37768edda577
Autor:
Daniel Felsky, Ismael Santa-Maria, Mehmet Ilyas Cosacak, Leon French, Julie A. Schneider, David A. Bennett, Philip L. De Jager, Caghan Kizil, Giuseppe Tosto
Publikováno v:
Neurobiology of Disease, Vol 176, Iss , Pp 105938- (2023)
Identifying ancestry-specific molecular profiles of late-onset Alzheimer's Disease (LOAD) in brain tissue is crucial to understand novel mechanisms and develop effective interventions in non-European, high-risk populations. We performed gene differen
Externí odkaz:
https://doaj.org/article/09de6a2816c94296a3ffd83441c8391c
Autor:
Weipang Chang, Andrea Pedroni, Maria Bertuzzi, Caghan Kizil, András Simon, Konstantinos Ampatzis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The mechanisms stimulating adult neurogenesis are unclear. Here, the authors show the contribution of cholinergic and GABAergic signalling within the locomotor network to spinal cord neurogenesis during homeostasis and regeneration, showing neurogene
Externí odkaz:
https://doaj.org/article/232a4e56e8564a4cac4759bf815d07cb
Autor:
Percival P. D’Gama, Tao Qiu, Mehmet Ilyas Cosacak, Dheeraj Rayamajhi, Ahsen Konac, Jan Niklas Hansen, Christa Ringers, Francisca Acuña-Hinrichsen, Subhra P. Hui, Emilie W. Olstad, Yan Ling Chong, Charlton Kang An Lim, Astha Gupta, Chee Peng Ng, Benedikt S. Nilges, Nachiket D. Kashikar, Dagmar Wachten, David Liebl, Kazu Kikuchi, Caghan Kizil, Emre Yaksi, Sudipto Roy, Nathalie Jurisch-Yaksi
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109775- (2021)
Summary: Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine disorders. The development of ciliated cells, their impact on CSF flow, and their function in brain and axial morphogenesis are not fully understood. We
Externí odkaz:
https://doaj.org/article/1dd717feda074446b65e421f9b70e01f
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 5, Pp 824-827 (2020)
Alzheimer’s disease cannot be cured as of yet. Our current understanding on the causes of Alzheimer’s disease is limited. To develop treatments, experimental models that represent a particular cellular phase of the disease and more rigorous scrut
Externí odkaz:
https://doaj.org/article/b7c74614ba22423e84de9a80a7e92004
Autor:
Carmen Diaz Verdugo, Sverre Myren-Svelstad, Ecem Aydin, Evelien Van Hoeymissen, Celine Deneubourg, Silke Vanderhaeghe, Julie Vancraeynest, Robbrecht Pelgrims, Mehmet Ilyas Cosacak, Akira Muto, Caghan Kizil, Koichi Kawakami, Nathalie Jurisch-Yaksi, Emre Yaksi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
During epileptic seizures, neural activity across the brain switches into a hyperactive and hypersynchronized state. Here, the authors report on the role of glia-glia and glia-neuron interactions in mediating the changes that result in the ictal stat
Externí odkaz:
https://doaj.org/article/22ccc4d2ad6d4f469da969fbd858fd86