Study of correlation between the NAT2 phenotype and genotype status among Greenlandic Inuit

Autor: Emilie, Birch Kristensen, Victor, Yakimov, Karen, Bjorn-Mortensen, Bolette, Soborg, Anders, Koch, Mikael, Andersson, Kasper, Birch Kristensen, Sascha Wilk, Michelsen, Line, Skotte, Anne, Ahrendt Bjerregaard, Meinolf, Blaszkewicz, Klaus, Golka, Jan G, Hengstler, Bjarke, Feenstra, Mads, Melbye, Frank, Geller

Publikováno v: EXCLI journal, 17:1043-1053
Kristensen, E B, Yakimov, V, Bjørn-Mortensen, K, Soborg, B, Koch, A, Andersson, M, Kristensen, K B, Michelsen, S W, Skotte, L, Bjerregaard, A A, Blaszkewicz, M, Golka, K, Hengstler, J G, Feenstra, B, Melbye, M & Geller, F 2018, ' Study of correlation between the NAT2 phenotype and genotype status among greenlandic inuit ', EXCLI Journal, vol. 17, pp. 1043-1053 . < https://www.excli.de/index.php/excli/article/view/660 >
EXCLI Journal

N-acetyltransferase 2 (NAT2) is the main enzyme metabolizing isoniazid and genotype-based treatment has been studied for years without becoming common practice. To investigate whether genotype-based isoniazid treatment is feasible in Greenland, we se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83dd477f9681bfc5020ed7f0fbe80b1
https://www.excli.de/index.php/excli/article/view/660/1865

Influence of the genetic polymorphism in the 5′-noncoding region of the CYP1A2 gene on CYP1A2 phenotype and urinary mutagenicity in smokers

Autor: Pasquale Gregorio, Erminio Clonfero, Alessandra Pulliero, Silvia Lupi, Sofia Pavanello

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 587:59-66

The functional significance of genetic polymorphisms on tobacco smoke-induced CYP1A2 activity was examined. The influence of three polymorphisms of the cytochrome P450 1A2 gene (CYP1A2) (-3860 G--A (allele *1C), -2467 T--delT (allele *1D), -163C--A (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ed8bd8a38dd8f4f44b9623c3d4dad9
https://doi.org/10.1016/j.mrgentox.2005.08.008

Exposition gegenüber Dioxinen und verwandten Substanzen

Autor: Abraham, Klaus

Die Akkumulation von lipophilen und biologisch persistenten Chlorkohlenwasserstoffen in der Nahrungskette und die infolgedessen auftretende relativ hohe Belastung gestillter Säuglinge hat zu Besorgnissen hinsichtlich möglicher negativer Folgen für

Externí odkaz: http://edoc.hu-berlin.de/18452/14507

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