Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Caffaro, Carolina E."'
Autor:
Kristine M San Jose Gall, Marcos Milla, Caffaro Carolina E, Michael J. Pena, Laura K. Shawver, Ingrid B. Joseph, Ptacin Jerod, David B. Chen, Nicole V Acuff, Lina Ma, Lilia K. Koriazova, Yelena Pavlova, Hans R. Aerni, Rob W Herman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
The implementation of applied engineering principles to create synthetic biological systems promises to revolutionize medicine, but application of fundamentally redesigned organisms has thus far not impacted practical drug development. Here we utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5732ddaedc3b48d14ed6d810fb3614aa
https://doaj.org/article/1eeb5f339edc4637a3c9f0f0c17dcf95
https://doaj.org/article/1eeb5f339edc4637a3c9f0f0c17dcf95
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2006 Oct . 103(44), 16176-16181.
Externí odkaz:
https://www.jstor.org/stable/30052132
Publikováno v:
In Journal of Biological Chemistry 6 August 2010 285(32):24600-24608
Akademický článek
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Publikováno v:
In Journal of Biological Chemistry 21 September 2007 282(38):27970-27975
Autor:
Donald R. Shaffer, Donald Jackson, Kelly Balko, Liqing Chen, Xiangming Li, Nicole Acuff, Chaomei Shi, Joachim Theilhaber, Yu-an Zhang, Julie-Ann Gavigan, Christen Buetz, Virna Cortez-Retamozo, Michael Lampa, Jill Mooney, Giovanni Abbadessa, Marcos Milla, Caffaro Carolina E, Timothy R. Wagenaar
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A636-A636
BackgroundSAR444245 is a non-alpha IL-2 Synthorin TM molecule designed with a site-specific non-natural amino acid serving as a bioconjugation site for a single PEG. The non-natural amino acid is positioned to enable the PEG bioconjugation to obscure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50bf6ba11e271380c0648bc689da26ea
https://doi.org/10.1136/jitc-2021-sitc2021.606
https://doi.org/10.1136/jitc-2021-sitc2021.606
Publikováno v:
In Journal of Biological Chemistry 16 September 2005 280(37):32168-32176
Autor:
Yorke Zhang, Floyd E. Romesberg, Court R. Turner, Kristine M. San Jose, Ptacin Jerod, Hans R. Aerni, Emil C. Fischer, Aaron W. Feldman, Caffaro Carolina E
Publikováno v:
Nature
Since at least the last common ancestor of all life on Earth, genetic information has been stored in a four-letter alphabet that is propagated and retrieved by the formation of two base pairs. The central goal of synthetic biology is to create new li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdf92c14a8c16c93362de3b3dd25ba5
https://pubmed.ncbi.nlm.nih.gov/29189787
https://pubmed.ncbi.nlm.nih.gov/29189787
Autor:
R.W. Herman, Lilia K. Koriazova, David B. Chen, Ptacin Jerod, L.K. Shawver, K.M. San Jose, T.K. Ismaili, Lina Ma, Marcos Milla, Michael J. Pena, Caffaro Carolina E, J. Nguyen, Yelena Pavlova, N. Singh, Ingrid B. Joseph, Hans R. Aerni, S. Li
Publikováno v:
Annals of Oncology. 30:v501
Background THOR-707 is a reprogrammed, site-directed, single pegylated, recombinant human IL-2 (rIL-2) variant that lacks binding affinity for the α chain of the IL-2 receptor. Because THOR-707 has near-native binding affinity for the βγ chain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39915bf6c2a4e1fd3fb48ba423f47f30
https://doi.org/10.1093/annonc/mdz253.051
https://doi.org/10.1093/annonc/mdz253.051
Autor:
Lilia K. Koriazova, Hans R. Aerni, Michael J. Pena, Jasmine Nguyen, Ken Bragstad, Shukuan Li, Marcos Milla, Yelena Pavlova, Caffaro Carolina E, Ptacin Jerod, Robert W. Herman, Kristine M. San Jose, David B. Chen, Lina Ma, Ingrid B. Joseph, Laura K. Shawver
Publikováno v:
Cancer Research. 79:3258-3258
Aldesleukin is a recombinant form of IL-2 approved for metastatic melanoma and renal cell carcinoma that induced complete, durable remissions in certain patients. Yet, its use is infrequent because of vascular leak syndrome (VLS), a severe dose-limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f4bcec31c14b1593f1218cdd2ea39f0
https://doi.org/10.1158/1538-7445.am2019-3258
https://doi.org/10.1158/1538-7445.am2019-3258