Výsledky vyhledávání - "Caerin peptide"

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Caerin 1.1 and 1.9 peptides halt B16 melanoma metastatic tumours via expanding cDC1 and reprogramming tumour macrophages

Autor: Quanlan Fu, Yuandong Luo, Junjie Li, Hejie Li, Xiaosong Liu, Zhu Chen, Guoying Ni, Tianfang Wang

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)

Abstract Background Cancer immunotherapy, particularly immune checkpoint inhibitors (ICBs) such as anti-PD-1 antibodies, has revolutionised cancer treatment, although response rates vary among patients. Previous studies have demonstrated that caerin

Externí odkaz: https://doaj.org/article/c04e3ce018cb49acbc9c5a968c9b61a4

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Mg alloy surface immobilised with caerin peptides acquires enhanced antibacterial ability and putatively improved corrosion resistance

Autor: Wang, Tianfang ^{a, 1}, Ni, Guoying ^{a, b, 1}, Furushima, Tsuyoshi ^c, Diao, Hui ^d, Zhang, Pingping ^e, Chen, Shu ^e, Fogarty, Conor E. ^a, Jiang, Zhengyi ^f, Liu, Xiaosong ^{a, e, ⁎}, Li, Hejie ^{a, c, ⁎⁎}

Publikováno v: In Materials Science & Engineering C February 2021 121

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Akademický článek

131I-Caerin 1.1 and 131I-Caerin 1.9 for the treatment of non-small-cell lung cancer

Autor: Na Liu, Tiantian He, Zewei Xiao, Juan Du, Keke Zhu, Xiongying Liu, Tongsheng Chen, Wenjuan Liu, Guoying Ni, Xiaosong Liu, Tianfang Wang, Jiangtao Quan, Jinhe Zhang, Peipei Zhang, Jianwei Yuan

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

ObjectiveTo investigate the effect of the 131I-labeled high-affinity peptides Caerin 1.1 and Caerin 1.9 for the treatment of A549 human NSCLC cells.Methods① 3-[4,5-Dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) and plate clone formati

Externí odkaz: https://doaj.org/article/3c2d54a4f4ce4e13881bd4cd660c2e18

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Topical Application of Temperature-Sensitive Gel Containing Caerin 1.1 and 1.9 Peptides on TC-1 Tumour-Bearing Mice Induced High-Level Immune Response in the Tumour Microenvironment

Autor: Guoying Ni, Xiaosong Liu, Hejie Li, Conor E. Fogarty, Shu Chen, Pingping Zhang, Ying Liu, Xiaolian Wu, Ming Q. Wei, Guoqiang Chen, Ping Zhang, Tianfang Wang

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

The development of topical cream drugs that increase the immune activation of tumour-infiltrating lymphocytes against tumour and chronic viral infection-associated lesions is of great immunotherapeutic significance. This study demonstrates that the t

Externí odkaz: https://doaj.org/article/785620b69a25494cb0d478afd06f6aae

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Synthesized natural peptides from amphibian skin secretions increase the efficacy of a therapeutic vaccine by recruiting more T cells to the tumour site

Autor: Xuan Pan, Bowei Ma, Xinchao You, Shu Chen, Jialing Wu, Tianfang Wang, Shelley F. Walton, Jianwei Yuan, Xiaolian Wu, Guoqiang Chen, Yuejian Wang, Guoying Ni, Xiaosong Liu

Publikováno v: BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-13 (2019)

Abstract Background Therapeutic vaccines against cervical cancer remain ineffective. Previously, we demonstrated that blocking the signalling of a cytokine, interleukin 10, at the time of immunisation elicited significantly higher numbers of antigen

Externí odkaz: https://doaj.org/article/b342c29808db4b1f9448500bfe9612ab

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Akademický článek

Intratumoral injection of caerin 1.1 and 1.9 peptides increases the efficacy of vaccinated TC‐1 tumor‐bearing mice with PD‐1 blockade by modulating macrophage heterogeneity and the activation of CD8+ T cells in the tumor microenvironment

Autor: Guoying Ni, Xiaodan Yang, Junjie Li, Xiaolian Wu, Ying Liu, Hejie Li, Shu Chen, Conor E Fogarty, Ian H Frazer, Guoqiang Chen, Xiaosong Liu, Tianfang Wang

Publikováno v: Clinical & Translational Immunology, Vol 10, Iss 8, Pp n/a-n/a (2021)

Abstract Objectives Developing a vaccine formula that alters the tumor‐infiltrating lymphocytes to be more immune active against a tumor is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction wit

Externí odkaz: https://doaj.org/article/bd0835a9ff6f43a48ad7e1747156fc0f

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Host-Defense Peptides Caerin 1.1 and 1.9 Stimulate TNF-Alpha-Dependent Apoptotic Signals in Human Cervical Cancer HeLa Cells

Autor: Guoying Ni, Shu Chen, Mo Chen, Jialing Wu, Binbin Yang, Jianwei Yuan, Shelley F. Walton, Hejie Li, Ming Q. Wei, Yuejian Wang, Guoqiang Chen, Xiaosong Liu, Tianfang Wang

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Host defense caerin 1.1 and 1.9 peptides, isolated from the glandular secretion of Australian tree frogs, the genus Litoria, have been previously shown to have multiple biological activities, including the inhibition of human papillomavirus (HPV) 16

Externí odkaz: https://doaj.org/article/a440bb55b4dd4979b4d12dceee071877

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Akademický článek

Caerin 1 Antimicrobial Peptides that Inhibit HIV and Neisseria May Spare Protective Lactobacilli

Autor: Louise A. Rollins-Smith, Patricia B. Smith, Anna M. Ledeczi, Julia M. Rowe, Laura K. Reinert

Publikováno v: Antibiotics, Vol 9, Iss 10, p 661 (2020)

Although acquired immunodeficiency syndrome (AIDS) caused by the human immunodeficiency virus (HIV) is a manageable disease for many, it is still a source of significant morbidity and economic hardship for many others. The predominant mode of transmi

Externí odkaz: https://doaj.org/article/8dac9bf211994601a2997ec4dcbb4df6

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