Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Caenorhabditis elegans/physiology"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 7, p e1008002 (2020)
PLoS computational biology, 16 (7
PLoS Computational Biology
PLoS computational biology, 16 (7
PLoS Computational Biology
Ageing affects a wide range of phenotypes at all scales, but an objective measure of ageing remains challenging, even in simple model organisms. To measure the ageing process, we characterized the sequence of alterations of multiple phenotypes at org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc0150923ddefcfc1c9ce0cd6b43aaa
https://doaj.org/article/eea0ba3374a643178d22dd8a0638107b
https://doaj.org/article/eea0ba3374a643178d22dd8a0638107b
Autor:
Hitoshi Okamura, Jean-Michel Fustin, David Whitmore, Ellen Grünewald, Ryoichiro Kageyama, Maria Luísa Jabbur, Stephanie Tammam, Samantha J. Cargill, Marijke Versteven, Carl Hirschie Johnson, Melisa L. Lamberti, Christin Rakers, Kumiko Yoshioka-Kobayashi, P. Lynne Howell, Gerben van Ooijen, Diego A. Golombek, Takuya Matsuo, Rika Kojima, Ralf Stanewsky, Kensuke Kaneko, Kazuki Fukumoto, Shiqi Ye, Hideaki Kakeya, Yao Xu, Mayu Yamano, T. Katherine Tamai
Publikováno v:
Fustin, J-M, Ye, S, Rakers, C, Kaneko, K, Fukumoto, K, Yamano, M, Versteven, M, Grünewald, E, Cargill, S J, Tamai, T K, Xu, Y, Jabbur, M L, Kojima, R, Lamberti, M L, Yoshioka-Kobayashi, K, Whitmore, D, Tammam, S, Howell, P L, Kageyama, R, Matsuo, T, Stanewsky, R, Golombek, D A, Johnson, C H, Kakeya, H, Ooijen, G V & Okamura, H 2020, ' Methylation deficiency disrupts biological rhythms from bacteria to humans ', Communications Biology, vol. 3, no. 1, 211 . https://doi.org/10.1038/s42003-020-0942-0
Communications Biology
Fustin, J-M, Ye, S, Rakers, C, Kaneko, K, Fukumoto, K, Yamano, M, Versteven, M, Grunewald, E, Cargill, S, Tamai, T K, Xu, Y, Jabbur, M L, Kojima, R, Lamberti, M L, Yoshioka Kobayashi, K, Whitmore, D, Tammam, S, Howell, P L, Kageyama, R, Matsuo, T, Stanewsky, R, Golombek, D A, Johnson, C H, Kakeya, H, Van Ooijen, G & Okamura, H 2020, ' Methylation deficiency disrupts biological rhythms from bacteria to humans ', Communications biology, vol. 3, no. 1, 211 . https://doi.org/10.1038/s42003-020-0942-0
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology
Fustin, J-M, Ye, S, Rakers, C, Kaneko, K, Fukumoto, K, Yamano, M, Versteven, M, Grunewald, E, Cargill, S, Tamai, T K, Xu, Y, Jabbur, M L, Kojima, R, Lamberti, M L, Yoshioka Kobayashi, K, Whitmore, D, Tammam, S, Howell, P L, Kageyama, R, Matsuo, T, Stanewsky, R, Golombek, D A, Johnson, C H, Kakeya, H, Van Ooijen, G & Okamura, H 2020, ' Methylation deficiency disrupts biological rhythms from bacteria to humans ', Communications biology, vol. 3, no. 1, 211 . https://doi.org/10.1038/s42003-020-0942-0
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
The methyl cycle is a universal metabolic pathway providing methyl groups for the methylation of nuclei acids and proteins, regulating all aspects of cellular physiology. We have previously shown that methyl cycle inhibition in mammals strongly affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d6e5be01b1272356d531f73855b32e
https://doi.org/10.1038/s42003-020-0942-0
https://doi.org/10.1038/s42003-020-0942-0
Autor:
Jerry S. Chen, William P. Schreiner, Laura B. Chipman, Ian Nicastro, James P. Broughton, Amy E. Pasquinelli, Antti P. Aalto
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 6, p e1007379 (2018)
Aalto, A P, Nicastro, I A, Broughton, J P, Chipman, L B, Schreiner, W P, Chen, J S & Pasquinelli, A E 2018, ' Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging ', PLoS Genetics, vol. 14, no. 6, e1007379 . https://doi.org/10.1371/journal.pgen.1007379
PLoS Genetics, Vol 14, Iss 6, p e1007379 (2018)
Aalto, A P, Nicastro, I A, Broughton, J P, Chipman, L B, Schreiner, W P, Chen, J S & Pasquinelli, A E 2018, ' Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging ', PLoS Genetics, vol. 14, no. 6, e1007379 . https://doi.org/10.1371/journal.pgen.1007379
Argonaute (AGO) proteins partner with microRNAs (miRNAs) to target specific genes for post-transcriptional regulation. During larval development in Caenorhabditis elegans, Argonaute-Like Gene 1 (ALG-1) is the primary mediator of the miRNA pathway, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c339d2036546fbb41164f18aa4f504
http://europepmc.org/articles/PMC6013023
http://europepmc.org/articles/PMC6013023
Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly
Autor:
Patrícia A. Simões, Reto Gassmann, Cátia de Carvalho, Rita M. Reis, Daniel José Barbosa, Ricardo Celestino, Dhanya K. Cheerambathur, Helena R. Pires, Cláudia Pereira, José B. Gama, Ana Carvalho, João Amorim
Publikováno v:
Gama, J B, Pereira, C, Simões, P A, Celestino, R, Reis, R M, Barbosa, D J, Pires, H R, Carvalho, C, Amorim, J, Carvalho, A X, Cheerambathur, D K & Gassmann, R 2017, ' Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly ', Journal of Cell Biology, vol. 216, no. 4, pp. 943-960 . https://doi.org/10.1083/jcb.201610108
The Journal of Cell Biology
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The Journal of Cell Biology
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The dynein motor is recruited to the kinetochore to capture spindle microtubules and control the spindle assembly checkpoint. Gama et al. reveal the molecular mechanism of how the Rod–Zw10–Zwilch complex and Spindly mediate dynein recruitment in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4dd69b6f9537932d3a7a0ac63af051
https://hdl.handle.net/20.500.11820/cfdc5439-c4c9-435e-8386-09e192882255
https://hdl.handle.net/20.500.11820/cfdc5439-c4c9-435e-8386-09e192882255
Autor:
Noboru Mizushima, J. Wade Harper, Qing Zhong, Frank Madeo, Sharon A. Tooze, Malene Hansen, Marja Jäättelä, Anne Simonsen, Beth Levine, Ana Maria Cuervo, Eric H. Baehrecke, Nektarios Tavernarakis, Alicia Meléndez, Douglas R. Green, Tamotsu Yoshimori, Claudine Kraft, Anna Katharina Simon, Sascha Martens, Charleen T. Chu, Lorenzo Galluzzi, Kevin M. Ryan, Gábor Juhász, Laura Santambrogio, David A. Gewirtz, Terje Johansen, David C. Rubinsztein, Hans-Uwe Simon, Gian Maria Fimia, Jennifer Martinez, Jayanta Debnath, Leon Murphy, Carlos López-Otín, Augustine M.K. Choi, Zhenyu Yue, María Isabel Colombo, Simone Fulda, José Manuel Bravo-San Pedro, Patricia Boya, Andrea Ballabio, Vojo Deretic, Guido Kroemer, Junying Yuan, Nicholas T. Ktistakis, Luca Scorrano, Patrice Codogno, Eeva-Liisa Eskelinen, Christian Münz, Alec C. Kimmelman, Josef M. Penninger, Sharad Kumar, Fulvio Reggiori, Ivan Dikic, Francesco Cecconi, Mauro Piacentini
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
The EMBO journal, vol 36, iss 13
Galluzzi, L, Baehrecke, E H, Ballabio, A, Boya, P, Bravo-San Pedro, J M, Cecconi, F, Choi, A M, Chu, C T, Codogno, P, Colombo, M I, Cuervo, A M, Debnath, J, Deretic, V, Dikic, I, Eskelinen, E-L, Fimia, G M, Fulda, S, Gewirtz, D A, Green, D R, Hansen, M, Harper, J W, Jäättelä, M, Johansen, T, Juhasz, G, Kimmelman, A C, Kraft, C, Ktistakis, N T, Kumar, S, Levine, B, Lopez-Otin, C, Madeo, F, Martens, S, Martinez, J, Melendez, A, Mizushima, N, Münz, C, Murphy, L O, Penninger, J M, Piacentini, M, Reggiori, F, Rubinsztein, D C, Ryan, K M, Santambrogio, L, Scorrano, L, Simon, A K, Simon, H-U, Simonsen, A, Tavernarakis, N, Tooze, S A, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q & Kroemer, G 2017, ' Molecular definitions of autophagy and related processes ', The EMBO Journal, vol. 36, no. 13, pp. 1811-1836 . https://doi.org/10.15252/embj.201796697
instname
The EMBO journal, vol 36, iss 13
Galluzzi, L, Baehrecke, E H, Ballabio, A, Boya, P, Bravo-San Pedro, J M, Cecconi, F, Choi, A M, Chu, C T, Codogno, P, Colombo, M I, Cuervo, A M, Debnath, J, Deretic, V, Dikic, I, Eskelinen, E-L, Fimia, G M, Fulda, S, Gewirtz, D A, Green, D R, Hansen, M, Harper, J W, Jäättelä, M, Johansen, T, Juhasz, G, Kimmelman, A C, Kraft, C, Ktistakis, N T, Kumar, S, Levine, B, Lopez-Otin, C, Madeo, F, Martens, S, Martinez, J, Melendez, A, Mizushima, N, Münz, C, Murphy, L O, Penninger, J M, Piacentini, M, Reggiori, F, Rubinsztein, D C, Ryan, K M, Santambrogio, L, Scorrano, L, Simon, A K, Simon, H-U, Simonsen, A, Tavernarakis, N, Tooze, S A, Yoshimori, T, Yuan, J, Yue, Z, Zhong, Q & Kroemer, G 2017, ' Molecular definitions of autophagy and related processes ', The EMBO Journal, vol. 36, no. 13, pp. 1811-1836 . https://doi.org/10.15252/embj.201796697
26 p.-1 fig.-1 tab. Galluzzi, Lorenzo et al.
Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear
Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::118f42b2cc0a7a94753b62cff02891cd
http://hdl.handle.net/10261/153387
http://hdl.handle.net/10261/153387
Autor:
Miersch, Claudia
The nematode Caenorhabditis elegans (C. elegans) contains two sexes, males and hermaphrodites, which are highly dimorphic in anatomy, nervous system and behavior. However, the physiology of males in comparison to hermaphrodites under normal feeding c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c0cbbc13b1e9c2b83ac621763982888a
https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00004413/eDiss_CMiersch.pdf
https://macau.uni-kiel.de/servlets/MCRFileNodeServlet/dissertation_derivate_00004413/eDiss_CMiersch.pdf
14-3-3 proteins are evolutionarily conserved and ubiquitous proteins that function in a wide variety of biological processes. Here we define a new role for C. elegans 14-3-3 proteins in life span regulation. We identify two C. elegans 14-3-3 proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______185::8f45f2179ab8ae3f9f05d95e8eee7afd
https://infoscience.epfl.ch/record/125662
https://infoscience.epfl.ch/record/125662
Publikováno v:
Scopus-Elsevier
Since the advent of microarrays, vast amounts of gene expression data have been generated. However, these microarray data fail to reveal the transcription regulatory mechanisms that underlie differential gene expression, because the identity of the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3683cda5521fcf8fe52b9805f65103de
https://infoscience.epfl.ch/record/125659
https://infoscience.epfl.ch/record/125659