Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Cadieux Jean-Jacques"'
Autor:
Shaoyi Sun, Ray Chui, Ivana Rajlic, Jonathan Langille, Qi Jia, Shifeng Liu, Jianyu Sun, Wendy Young, Sultan Chowdhury, Jianmin Fu, Jing Zhong, Mikhail Chafeev, Zaihui Zhang, Sazzad Hossain, Henry Verschoof, Mark Wood, Kuldip Khakh, Tom Hsieh, Serguei Sviridov, Audrey Wang, Xing Cheng, Rainbow Kwan, Cadieux Jean-Jacques
Publikováno v:
Medicinal Chemistry Research. 22:1825-1836
The structure–activity relationship of a new series of tetracyclic spirooxindoles led to the discovery of compound 25a, a potent hNaV1.7 blocker with improved ADME properties and in vivo efficacy in the CFA-induced inflammatory pain model.
Autor:
Shifeng Liu, Jianmin Fu, Rainbow Kwan, Ray Chui, Cadieux Jean-Jacques, Mikhail Chafeev, Vandna Raina, Wendy B. Young, Sultan Chowdhury, Jianyu Sun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3676-3681
Starting from the oxindole 2a identified through a high-throughput screening campaign, a series of Na(V)1.7 blockers were developed. Following the elimination of undesirable structural features, preliminary optimization of the oxindole C-3 and N-1 su
Autor:
Clint Young, Simon N. Pimstone, Charles J. Cohen, Nicola Anne Price, Y P Goldberg, Cadieux Jean-Jacques, Robin Sherrington, Rostam Namdari
Publikováno v:
PainReferences. 155(4)
Autor:
Zaihui Zhang, Jing Zhong, Laszlo G. Ratkay, Jay Thompson, Jianmin Fu, Joseph Sanghara, Rainbow Kwan, Cadieux Jean-Jacques, Y. Paul Goldberg, Maryanne Mattice, Alison Brownlie-Cutts
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
Three distinct series of substituted pyrazole blockers of divalent metal transporter 1 (DMT1) were elaborated from the high-throughput screening pyrazolone hit 1. Preliminary hit-to-lead efforts revealed a preference for electron-withdrawing substitu
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